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| TissGeneSummary for SLC26A8 |
 Gene summary |
| Basic gene information | Gene symbol | SLC26A8 |
| Gene name | solute carrier family 26 (anion exchanger), member 8 | |
| Synonyms | SPGF3|TAT1 | |
| Cytomap | UCSC genome browser: 6p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001193476.1, NM_052961.3,NM_138718.2, | |
| Description | anion transporter/exchanger-8testis anion transporter 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608480 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000112053 | ||
| HPRD : 12241 | ||
| Vega : OTTHUMG00000014586 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC26A8 | |
| BioGPS: 116369 | ||
| Pathway | NCI Pathway Interaction Database: SLC26A8 | |
| KEGG: SLC26A8 | ||
| REACTOME: SLC26A8 | ||
| Pathway Commons: SLC26A8 | ||
| Context | iHOP: SLC26A8 | |
| ligand binding site mutation search in PubMed: SLC26A8 | ||
| UCL Cancer Institute: SLC26A8 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SLC26A8 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006820 | anion transport | 11834742 | GO:0006821 | chloride transport | 1183472 | GO:0008272 | sulfate transport | 1183472 | GO:0019532 | oxalate transport | 1183472 | GO:1902358 | sulfate transmembrane transport | 1183472 | GO:1902476 | chloride transmembrane transport | 1183472 | GO:0006820 | anion transport | 11834742 | GO:0006821 | chloride transport | 1183472 | GO:0008272 | sulfate transport | 1183472 | GO:0019532 | oxalate transport | 1183472 | GO:1902358 | sulfate transmembrane transport | 1183472 | GO:1902476 | chloride transmembrane transport | 1183472 |
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| TissGeneExp for SLC26A8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for SLC26A8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC26A8 |
| TissGeneSNV for SLC26A8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R520C | SKCM | 2 |
| p.L717V | BLCA | 2 |
| p.R87* | UCEC | 2 |
| p.M832V | SKCM | 1 |
| p.K571E | PRAD | 1 |
| p.G738E | LUSC | 1 |
| p.V161I | READ | 1 |
| p.E682K | SKCM | 1 |
| p.S916Y | UCEC | 1 |
| p.P662Q | LUSC | 1 |
| p.S227F | SKCM | 1 |
| p.E311K | SKCM | 1 |
| p.R63_splice | OV | 1 |
| p.V578A | SKCM | 1 |
| p.P711S | SKCM | 1 |
| p.R880Q | ESCA | 1 |
| p.S183L | BLCA | 1 |
| p.S509* | BLCA | 1 |
| p.Q145X | PAAD | 1 |
| p.L393V | READ | 1 |
| p.R71* | UCEC | 1 |
| p.P634S | SKCM | 1 |
| p.R18* | UCEC | 1 |
| p.R63H | READ | 1 |
| p.L585V | OV | 1 |
| p.E635K | SKCM | 1 |
| p.R71* | PRAD | 1 |
| p.K356Q | UCEC | 1 |
| p.V668M | UCEC | 1 |
| p.E33D | CESC | 1 |
| p.R545Q | LUAD | 1 |
| p.R798M | HNSC | 1 |
| p.E658A | SKCM | 1 |
| p.E81Q | BLCA | 1 |
| p.A2V | STAD | 1 |
| p.H921Y | SKCM | 1 |
| p.R298K | BLCA | 1 |
| p.K89N | LGG | 1 |
| p.D790N | STAD | 1 |
| p.M252I | LUAD | 1 |
| p.Q421* | SKCM | 1 |
| p.Q851* | LGG | 1 |
| p.P551T | BLCA | 1 |
| p.F774L | UCEC | 1 |
| p.A701V | GBM | 1 |
| p.G425E | SKCM | 1 |
| p.V792M | LUSC | 1 |
| p.T202A | LGG | 1 |
| p.Q37R | COAD | 1 |
| p.R927C | UCEC | 1 |
| p.P346S | SKCM | 1 |
| p.V138A | UCEC | 1 |
| p.G964S | OV | 1 |
| p.R954H | CESC | 1 |
| p.R87X | COAD | 1 |
| p.R880W | SKCM | 1 |
| p.G696* | UCEC | 1 |
| p.K605N | UCEC | 1 |
| p.A791T | UCEC | 1 |
| p.D958N | SKCM | 1 |
| p.V519I | CESC | 1 |
| p.R6K | SKCM | 1 |
| p.Q145* | PAAD | 1 |
| p.P711T | LUAD | 1 |
| p.V740A | SKCM | 1 |
| p.P914S | SKCM | 1 |
| p.K841I | SKCM | 1 |
| p.G426E | SKCM | 1 |
| p.L717I | SARC | 1 |
| p.R87X | READ | 1 |
| p.P185S | ESCA | 1 |
| p.G552V | PRAD | 1 |
| p.V173I | STAD | 1 |
| p.D337A | BLCA | 1 |
| p.S690* | BLCA | 1 |
| p.V741I | COAD | 1 |
| p.P225L | STAD | 1 |
| p.R71Q | HNSC | 1 |
| p.F370V | BLCA | 1 |
| p.C72Y | LGG | 1 |
| p.R292Q | SKCM | 1 |
| p.E33K | SKCM | 1 |
| p.R41K | SKCM | 1 |
| p.G603R | SKCM | 1 |
| p.Y568D | STAD | 1 |
| p.S509L | BLCA | 1 |
| p.E968* | UCEC | 1 |
| p.S666L | SKCM | 1 |
| p.A656P | THCA | 1 |
| p.T34P | LUSC | 1 |
| p.Q171R | SKCM | 1 |
| p.Q171R | STAD | 1 |
| p.V668A | LUAD | 1 |
| p.M730K | GBM | 1 |
| p.L755F | BLCA | 1 |
| p.D633N | SKCM | 1 |
| p.I51M | HNSC | 1 |
| p.S183L | SKCM | 1 |
| p.A701V | ESCA | 1 |
| p.G110R | HNSC | 1 |
| p.A459V | STAD | 1 |
| p.P912S | DLBC | 1 |
| p.S134L | STAD | 1 |
| p.I639V | COAD | 1 |
| p.G552E | SKCM | 1 |
| p.D579G | PAAD | 1 |
| p.K89Q | UCEC | 1 |
| p.T334M | LGG | 1 |
| p.F556L | HNSC | 1 |
| p.G802C | UCEC | 1 |
| p.S183L | SARC | 1 |
| p.P620L | SKCM | 1 |
| p.G604* | UCEC | 1 |
| p.E33V | KIRC | 1 |
| p.L793Q | STAD | 1 |
| p.R621G | COAD | 1 |
| p.R737Q | LGG | 1 |
| p.P78L | SKCM | 1 |
| p.V60I | UCEC | 1 |
| p.R71* | GBM | 1 |
| p.V792M | HNSC | 1 |
| p.K586I | CESC | 1 |
| p.S820* | LUAD | 1 |
| p.Y30C | LGG | 1 |
| p.G103C | THYM | 1 |
| p.D614N | LUAD | 1 |
| p.V214I | LGG | 1 |
| p.N687D | HNSC | 1 |
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| TissGeneCNV for SLC26A8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC26A8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC26A8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| COAD (tumor) | COAD (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| KICH (tumor) | KICH (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SLC26A8, CFTR, RACGAP1, NXF1 (tumor) | SLC26A8, CFTR, RACGAP1, NXF1 (normal) |
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| TissGeneProg for SLC26A8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC26A8 |
| TissGeneDrug for SLC26A8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC26A8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019693 | HIV Infections | 8 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
| umls:C0007786 | Brain Ischemia | 1 | GAD |
| umls:C0010068 | Coronary heart disease | 1 | GAD |
| umls:C0013170 | Drug habituation | 1 | BeFree |
| umls:C0021364 | Male infertility | 1 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0024301 | Lymphoma, Follicular | 1 | BeFree |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | CTD_human |
| umls:C0036572 | Seizures | 1 | BeFree |
| umls:C0037889 | Hereditary spherocytosis | 1 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0403809 | Primary spermatogenic failure | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C1847540 | Azoospermia, Nonobstructive | 1 | CLINVAR,UNIPROT |
| umls:C2674218 | SPHEROCYTOSIS, TYPE 1 (disorder) | 1 | BeFree |
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