TissGeneSummary for CLNK |
Gene summary |
Basic gene information | Gene symbol | CLNK |
Gene name | cytokine-dependent hematopoietic cell linker | |
Synonyms | MIST | |
Cytomap | UCSC genome browser: 4p16.1 | |
Type of gene | protein-coding | |
RefGenes | NM_052964.2, | |
Description | mast cell immunoreceptor signal transducer | |
Modification date | 20141207 | |
dbXrefs | MIM : 611434 | |
HGNC : HGNC | ||
Ensembl : ENSG00000109684 | ||
HPRD : 14720 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CLNK | |
BioGPS: 116449 | ||
Pathway | NCI Pathway Interaction Database: CLNK | |
KEGG: CLNK | ||
REACTOME: CLNK | ||
Pathway Commons: CLNK | ||
Context | iHOP: CLNK | |
ligand binding site mutation search in PubMed: CLNK | ||
UCL Cancer Institute: CLNK | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of CLNK | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0035556 | intracellular signal transduction | 10744659 | GO:0035556 | intracellular signal transduction | 10744659 |
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TissGeneExp for CLNK |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | 6.326571549 | 2.516247549 | 3.810324 | 2.09E-07 | 9.01E-07 |
KIRC | -1.429901229 | 2.386293216 | -3.816194444 | 2.47E-33 | 5.89E-32 |
KIRP | -1.926310951 | 2.475376549 | -4.4016875 | 7.63E-16 | 2.41E-14 |
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TissGene-miRNA for CLNK |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CLNK |
TissGeneSNV for CLNK |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D16N | UCEC | 2 |
p.E281K | UCEC | 2 |
p.F332I | SKCM | 1 |
p.L348F | LUAD | 1 |
p.R292I | READ | 1 |
p.P109T | LUAD | 1 |
p.E365X | PRAD | 1 |
p.E95Q | LIHC | 1 |
p.H414Q | LUAD | 1 |
p.S119C | LUAD | 1 |
p.L187F | OV | 1 |
p.R257K | SKCM | 1 |
p.N232K | LUAD | 1 |
p.S139Y | CHOL | 1 |
p.Q269K | LUAD | 1 |
p.N256H | KIRP | 1 |
p.T248M | BRCA | 1 |
p.R292K | BLCA | 1 |
p.M263I | GBM | 1 |
p.D135E | SARC | 1 |
p.S188F | SKCM | 1 |
p.R198I | COAD | 1 |
p.R260K | CESC | 1 |
p.P200H | LUAD | 1 |
p.N256S | LIHC | 1 |
p.E281K | UCS | 1 |
p.K45R | OV | 1 |
p.E326K | SKCM | 1 |
p.S119F | BLCA | 1 |
p.L333M | STAD | 1 |
p.R52G | GBM | 1 |
p.G261R | COAD | 1 |
p.R270K | SKCM | 1 |
p.P420H | THYM | 1 |
p.P175H | LUAD | 1 |
p.T10A | UCEC | 1 |
p.D70Y | LUAD | 1 |
p.R32H | COAD | 1 |
p.R270I | BLCA | 1 |
p.F382L | LUAD | 1 |
p.D16N | PRAD | 1 |
p.P31L | DLBC | 1 |
p.L169H | MESO | 1 |
p.Q197H | CESC | 1 |
p.P175H | SARC | 1 |
p.I167V | BLCA | 1 |
p.R362C | DLBC | 1 |
p.T99A | BRCA | 1 |
p.L372M | COAD | 1 |
p.S65R | SKCM | 1 |
p.P178H | LUAD | 1 |
p.R316H | CESC | 1 |
p.P294L | SKCM | 1 |
p.P185T | THYM | 1 |
p.T127R | SARC | 1 |
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TissGeneCNV for CLNK |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CLNK |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE698729 | CLNK-CCT4 | chr4:10602096 | chr2:62095716 | |
Chimerdb3.0 | ChiTaRs | NA | AA225642 | C1orf116-CLNK | chr1:207195372 | chr4:10660219 |
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TissGeneNet for CLNK |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CLNK |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CLNK |
TissGeneDrug for CLNK |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CLNK |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002736 | Amyotrophic Lateral Sclerosis | 2 | GAD |
umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
umls:C0023895 | Liver diseases | 1 | BeFree |
umls:C0042900 | Vitiligo | 1 | CTD_human |
umls:C1623038 | Cirrhosis | 1 | BeFree |