TissGeneSummary for CATSPER1 |
Gene summary |
Basic gene information | Gene symbol | CATSPER1 |
Gene name | cation channel, sperm associated 1 | |
Synonyms | CATSPER|SPGF7 | |
Cytomap | UCSC genome browser: 11q12.1 | |
Type of gene | protein-coding | |
RefGenes | NM_053054.3, | |
Description | cation channel sperm-associated protein 1hCatSpersperm ion channelsperm-associated cation channel 1 | |
Modification date | 20141219 | |
dbXrefs | MIM : 606389 | |
HGNC : HGNC | ||
Ensembl : ENSG00000175294 | ||
HPRD : 09396 | ||
Vega : OTTHUMG00000166668 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CATSPER1 | |
BioGPS: 117144 | ||
Pathway | NCI Pathway Interaction Database: CATSPER1 | |
KEGG: CATSPER1 | ||
REACTOME: CATSPER1 | ||
Pathway Commons: CATSPER1 | ||
Context | iHOP: CATSPER1 | |
ligand binding site mutation search in PubMed: CATSPER1 | ||
UCL Cancer Institute: CATSPER1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CATSPER1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CATSPER1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.080796882 | -2.256690742 | 1.17589386 | 1.10E-16 | 6.34E-16 |
THCA | 1.294280251 | -1.947712969 | 3.24199322 | 3.50E-16 | 5.74E-15 |
KIRC | -0.701060333 | -2.255426999 | 1.554366667 | 4.81E-16 | 2.61E-15 |
KIRP | -0.078787069 | -2.381721444 | 2.302934375 | 3.03E-09 | 2.54E-08 |
LUSC | -0.716439091 | 1.80838836 | -2.524827451 | 1.23E-18 | 1.21E-17 |
COAD | -1.159852213 | -2.171136828 | 1.011284615 | 0.000273 | 0.000899463 |
BLCA | 0.711073293 | -1.529795128 | 2.240868421 | 2.42E-05 | 0.000376369 |
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TissGene-miRNA for CATSPER1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CATSPER1 |
TissGeneSNV for CATSPER1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V166M | HNSC | 2 |
p.D68N | COAD | 2 |
p.V105I | UCEC | 1 |
p.V457F | LIHC | 1 |
p.Q467H | LUAD | 1 |
p.H148D | ESCA | 1 |
p.R89K | BLCA | 1 |
p.S265N | PAAD | 1 |
p.V166M | COAD | 1 |
p.Y132C | UCEC | 1 |
p.E695D | LGG | 1 |
p.R345H | ESCA | 1 |
p.A761V | ESCA | 1 |
p.E450K | PAAD | 1 |
p.R33M | STAD | 1 |
p.L601F | SKCM | 1 |
p.D337N | SKCM | 1 |
p.R365W | UCS | 1 |
p.G95S | PAAD | 1 |
p.R373H | THYM | 1 |
p.T322S | BLCA | 1 |
p.T730A | COAD | 1 |
p.L663P | LIHC | 1 |
p.Y318H | UCEC | 1 |
p.H250L | SKCM | 1 |
p.V166M | UCEC | 1 |
p.G156C | LUAD | 1 |
p.R371H | HNSC | 1 |
p.E750A | PAAD | 1 |
p.C593G | SARC | 1 |
p.A308T | STAD | 1 |
p.E83D | UCEC | 1 |
p.A342D | HNSC | 1 |
p.V749M | SKCM | 1 |
p.W511X | SKCM | 1 |
p.P7H | LUAD | 1 |
p.S163F | SKCM | 1 |
p.D281N | SKCM | 1 |
p.T444I | HNSC | 1 |
p.E171K | BLCA | 1 |
p.A553S | COAD | 1 |
p.G340S | STAD | 1 |
p.R437W | LGG | 1 |
p.A495V | SKCM | 1 |
p.D768N | UCEC | 1 |
p.G170D | BLCA | 1 |
p.S107F | SKCM | 1 |
p.R258S | KIRC | 1 |
p.S673R | SARC | 1 |
p.S57T | SARC | 1 |
p.R345C | UCEC | 1 |
p.F22L | READ | 1 |
p.P100T | OV | 1 |
p.R437Q | LUAD | 1 |
p.Q153H | PAAD | 1 |
p.S178Y | LUAD | 1 |
p.H116R | SKCM | 1 |
p.S197Y | LUAD | 1 |
p.Q301E | BRCA | 1 |
p.S25C | BLCA | 1 |
p.G150D | UCEC | 1 |
p.E438K | UCEC | 1 |
p.G150D | ESCA | 1 |
p.R357Q | UCEC | 1 |
p.H231Y | HNSC | 1 |
p.D672N | SKCM | 1 |
p.P93S | LGG | 1 |
p.A714V | UCEC | 1 |
p.A747E | UCS | 1 |
p.G146E | SKCM | 1 |
p.I440S | COAD | 1 |
p.Q257* | SARC | 1 |
p.R121C | STAD | 1 |
p.R692W | STAD | 1 |
p.H272Y | BLCA | 1 |
p.G103S | SKCM | 1 |
p.Q222* | UCEC | 1 |
p.W511* | SKCM | 1 |
p.Q11H | COAD | 1 |
p.D114N | SKCM | 1 |
p.F510L | LIHC | 1 |
p.A641T | UCEC | 1 |
p.Q211E | OV | 1 |
p.R552W | DLBC | 1 |
p.E733K | BLCA | 1 |
p.R357W | UCEC | 1 |
p.G774R | SKCM | 1 |
p.L678Q | LIHC | 1 |
p.D15N | LUAD | 1 |
p.R228S | HNSC | 1 |
p.F66V | UCEC | 1 |
p.R332Q | THYM | 1 |
p.R757H | LIHC | 1 |
p.F517L | LUAD | 1 |
p.Q759P | STAD | 1 |
p.L504I | PAAD | 1 |
p.D20N | LUAD | 1 |
p.R345H | PAAD | 1 |
p.G134V | STAD | 1 |
p.A196D | THYM | 1 |
p.A685V | UCEC | 1 |
p.I370V | STAD | 1 |
p.H352Y | SKCM | 1 |
p.T293I | SKCM | 1 |
p.S579Y | UCEC | 1 |
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TissGeneCNV for CATSPER1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CATSPER1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CATSPER1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CATSPER1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CATSPER1 |
TissGeneDrug for CATSPER1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CATSPER1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0021364 | Male infertility | 3 | BeFree,LHGDN |
umls:C2751811 | Spermatogenic Failure 7 | 0 | CLINVAR,CTD_human |