TissGeneSummary for HRASLS5 |
Gene summary |
Basic gene information | Gene symbol | HRASLS5 |
Gene name | HRAS-like suppressor family, member 5 | |
Synonyms | HRLP5|HRSL5|RLP1|iNAT | |
Cytomap | UCSC genome browser: 11q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001146728.1, NM_001146729.1,NM_054108.3, | |
Description | Ca(2+)-independent N-acyltransferaseH-rev107-like protein 5HRAS-like suppressor 5calcium-independent phosphatidylethanolamine N-acyltransferaselecithin-retinol acyltransferase (LRAT)-like protein-1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611474 | |
HGNC : HGNC | ||
Ensembl : ENSG00000168004 | ||
HPRD : 13672 | ||
Vega : OTTHUMG00000167806 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HRASLS5 | |
BioGPS: 117245 | ||
Pathway | NCI Pathway Interaction Database: HRASLS5 | |
KEGG: HRASLS5 | ||
REACTOME: HRASLS5 | ||
Pathway Commons: HRASLS5 | ||
Context | iHOP: HRASLS5 | |
ligand binding site mutation search in PubMed: HRASLS5 | ||
UCL Cancer Institute: HRASLS5 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of HRASLS5 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HRASLS5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 2.335497372 | 5.277928074 | -2.942430702 | 1.01E-21 | 8.19E-21 |
LUSC | -1.410417798 | 1.760007692 | -3.17042549 | 7.17E-15 | 4.33E-14 |
LUAD | -0.052438623 | 2.006778618 | -2.059217241 | 4.69E-11 | 2.94E-10 |
KIRC | -0.966836181 | 0.678444375 | -1.645280556 | 8.88E-09 | 2.71E-08 |
HNSC | -1.976357789 | 0.187930583 | -2.164288372 | 2.08E-08 | 2.33E-07 |
PRAD | -0.414436501 | 1.546821191 | -1.961257692 | 1.29E-14 | 1.43E-12 |
COAD | -1.47901727 | 0.916848114 | -2.395865385 | 2.17E-06 | 1.13E-05 |
ESCA | -0.62531762 | 2.156718744 | -2.782036364 | 0.000303 | 0.006876245 |
KICH | 2.026469653 | 0.106829653 | 1.91964 | 0.00276 | 0.005514995 |
BLCA | -1.434379821 | 1.6837886 | -3.118168421 | 6.90E-06 | 0.000144248 |
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TissGene-miRNA for HRASLS5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HRASLS5 |
TissGeneSNV for HRASLS5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R130* | SKCM | 2 |
p.G123* | LUAD | 1 |
p.D191Y | LUAD | 1 |
p.S27L | CESC | 1 |
p.A7T | COAD | 1 |
p.E82Q | GBM | 1 |
p.R231K | SKCM | 1 |
p.D200N | SKCM | 1 |
p.A66T | COAD | 1 |
p.E144K | SKCM | 1 |
p.I223V | BLCA | 1 |
p.P198L | PAAD | 1 |
p.R246Q | OV | 1 |
p.C192Y | STAD | 1 |
p.G192R | LUAD | 1 |
p.D152Y | BLCA | 1 |
p.E61* | UCEC | 1 |
p.P274T | LUSC | 1 |
p.R140X | SKCM | 1 |
p.A113V | BLCA | 1 |
p.A243T | BLCA | 1 |
p.H235Y | UCEC | 1 |
p.R130Q | UCS | 1 |
p.S44L | BLCA | 1 |
p.G221R | SKCM | 1 |
p.E220V | BLCA | 1 |
p.G221E | SKCM | 1 |
p.A26D | THYM | 1 |
p.P68S | SKCM | 1 |
p.E166D | STAD | 1 |
p.R75K | PAAD | 1 |
p.A66T | UVM | 1 |
p.G123* | SARC | 1 |
p.P68L | PAAD | 1 |
p.P78L | PAAD | 1 |
p.E134K | SKCM | 1 |
p.D210N | SKCM | 1 |
p.P208L | PAAD | 1 |
p.Y133N | PRAD | 1 |
p.G126E | SKCM | 1 |
p.E242K | SKCM | 1 |
p.E234K | LUSC | 1 |
p.A56T | UVM | 1 |
p.E234* | UCEC | 1 |
p.I213V | BLCA | 1 |
p.D142Y | BLCA | 1 |
p.V234I | LUAD | 1 |
p.I267V | HNSC | 1 |
p.R85K | PAAD | 1 |
p.G133* | LUAD | 1 |
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TissGeneCNV for HRASLS5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HRASLS5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-91-6831-01A | RTN3-HRASLS5 | In-frame | Chr11:63449250 | Chr11:63233844 |
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TissGeneNet for HRASLS5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HRASLS5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HRASLS5 |
TissGeneDrug for HRASLS5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HRASLS5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |