TissGeneSummary for TRIM6 |
Gene summary |
Basic gene information | Gene symbol | TRIM6 |
Gene name | tripartite motif containing 6 | |
Synonyms | RNF89 | |
Cytomap | UCSC genome browser: 11p15.4 | |
Type of gene | protein-coding | |
RefGenes | NM_001003818.2, NM_001198644.1,NM_001198645.1,NM_058166.4, | |
Description | RING finger protein 89tripartite motif-containing 6tripartite motif-containing protein 6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607564 | |
HGNC : HGNC | ||
Ensembl : ENSG00000121236 | ||
HPRD : 12123 | ||
Vega : OTTHUMG00000150029 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRIM6 | |
BioGPS: 117854 | ||
Pathway | NCI Pathway Interaction Database: TRIM6 | |
KEGG: TRIM6 | ||
REACTOME: TRIM6 | ||
Pathway Commons: TRIM6 | ||
Context | iHOP: TRIM6 | |
ligand binding site mutation search in PubMed: TRIM6 | ||
UCL Cancer Institute: TRIM6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of TRIM6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0070206 | protein trimerization | 17156811 | GO:0070206 | protein trimerization | 17156811 |
Top |
TissGeneExp for TRIM6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.909326411 | 2.084745589 | -3.994072 | 1.49E-12 | 1.74E-11 |
PRAD | -0.624372027 | 0.636539512 | -1.260911538 | 2.75E-12 | 1.23E-10 |
Top |
TissGene-miRNA for TRIM6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for TRIM6 |
TissGeneSNV for TRIM6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R219X | COAD | 1 |
p.P299T | READ | 1 |
p.R459H | UCEC | 1 |
p.G428E | BRCA | 1 |
p.E237K | SKCM | 1 |
p.T455P | SKCM | 1 |
p.R25K | LGG | 1 |
p.R459C | UCEC | 1 |
p.W328* | SKCM | 1 |
p.E468G | PRAD | 1 |
p.L160F | SKCM | 1 |
p.R460C | BRCA | 1 |
p.C136Y | LUAD | 1 |
p.R16X | COAD | 1 |
p.G271E | SKCM | 1 |
p.P228H | UCEC | 1 |
p.G355R | SKCM | 1 |
p.K171T | ESCA | 1 |
p.E187K | BLCA | 1 |
p.R267C | READ | 1 |
p.R108W | THCA | 1 |
p.R459C | STAD | 1 |
p.N67K | SKCM | 1 |
p.R268* | SKCM | 1 |
p.R228W | ESCA | 1 |
p.R149Q | LUAD | 1 |
p.K238N | HNSC | 1 |
p.I105V | LIHC | 1 |
p.D250N | SKCM | 1 |
p.E236Q | KIRC | 1 |
p.F159V | KIRC | 1 |
p.R484H | STAD | 1 |
p.R512H | STAD | 1 |
p.L134P | LUAD | 1 |
p.C503X | THYM | 1 |
p.L333M | COAD | 1 |
p.W328X | SKCM | 1 |
p.R97W | STAD | 1 |
p.R352K | STAD | 1 |
p.V354A | LUAD | 1 |
p.N95K | SKCM | 1 |
p.A165V | READ | 1 |
p.P361L | SKCM | 1 |
p.R512H | PRAD | 1 |
Top |
TissGeneCNV for TRIM6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for TRIM6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BC136871 | TRIM6-TRIM34 | chr11:5612958 | chr11:5619944 |
Top |
TissGeneNet for TRIM6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for TRIM6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for TRIM6 |
TissGeneDrug for TRIM6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for TRIM6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |