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| TissGeneSummary for CLCNKB |
 Gene summary |
| Basic gene information | Gene symbol | CLCNKB |
| Gene name | chloride channel, voltage-sensitive Kb | |
| Synonyms | CLCKB|ClC-K2|ClC-Kb | |
| Cytomap | UCSC genome browser: 1p36 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000085.4, NM_001165945.2, | |
| Description | chloride channel protein ClC-Kbchloride channel, kidney, B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602023 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000184908 | ||
| HPRD : 03607 | ||
| Vega : OTTHUMG00000009530 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLCNKB | |
| BioGPS: 1188 | ||
| Pathway | NCI Pathway Interaction Database: CLCNKB | |
| KEGG: CLCNKB | ||
| REACTOME: CLCNKB | ||
| Pathway Commons: CLCNKB | ||
| Context | iHOP: CLCNKB | |
| ligand binding site mutation search in PubMed: CLCNKB | ||
| UCL Cancer Institute: CLCNKB | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of CLCNKB | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CLCNKB |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | 3.999712873 | 6.972382365 | -2.972669492 | 1.48E-22 | 9.36E-21 |
| COAD | -1.47383152 | 0.24836848 | -1.7222 | 2.12E-05 | 8.95E-05 |
| KIRC | 1.404815274 | 9.992169441 | -8.587354167 | 4.91E-48 | 3.67E-46 |
| BRCA | -0.962486041 | 0.464547292 | -1.427033333 | 2.52E-22 | 2.12E-21 |
| PRAD | -0.066379597 | 1.94344348 | -2.009823077 | 1.74E-14 | 1.67E-12 |
| LUSC | 0.06948047 | 1.805447137 | -1.735966667 | 3.27E-10 | 1.18E-09 |
| KIRP | 2.608700691 | 10.64908819 | -8.0403875 | 2.83E-16 | 1.01E-14 |
| HNSC | -1.130098873 | 1.353149964 | -2.483248837 | 2.91E-05 | 0.000148133 |
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| TissGene-miRNA for CLCNKB |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CLCNKB |
| TissGeneSNV for CLCNKB |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P513L | SKCM | 2 |
| p.P683L | SKCM | 2 |
| p.G35S | LUAD | 1 |
| p.R438H | MESO | 1 |
| p.L402I | LIHC | 1 |
| p.W389X | STAD | 1 |
| p.G139S | SKCM | 1 |
| p.R438C | PRAD | 1 |
| p.P422S | THYM | 1 |
| p.L558P | STAD | 1 |
| p.E649Q | BLCA | 1 |
| p.G308S | SKCM | 1 |
| p.F277C | COAD | 1 |
| p.G625V | UCEC | 1 |
| p.P500S | STAD | 1 |
| p.W27* | BLCA | 1 |
| p.P342L | KIRC | 1 |
| p.D68N | UCEC | 1 |
| p.L161F | SKCM | 1 |
| p.V98M | UCEC | 1 |
| p.R544C | HNSC | 1 |
| p.G189R | LIHC | 1 |
| p.S232C | BLCA | 1 |
| p.V376M | COAD | 1 |
| p.R22K | BLCA | 1 |
| p.R595L | SKCM | 1 |
| p.D140N | SKCM | 1 |
| p.R534Q | SKCM | 1 |
| p.P608S | SKCM | 1 |
| p.V576M | STAD | 1 |
| p.P513L | COAD | 1 |
| p.P394L | STAD | 1 |
| p.A204T | COAD | 1 |
| p.R272Q | BRCA | 1 |
| p.F44I | UCEC | 1 |
| p.R538H | PRAD | 1 |
| p.H480Y | BLCA | 1 |
| p.T244I | HNSC | 1 |
| p.E450D | LUAD | 1 |
| p.S232P | LUAD | 1 |
| p.S445Y | BLCA | 1 |
| p.E225K | BLCA | 1 |
| p.C157F | STAD | 1 |
| p.R27L | COAD | 1 |
| p.D363N | UCEC | 1 |
| p.R438C | HNSC | 1 |
| p.C292Y | STAD | 1 |
| p.S475L | HNSC | 1 |
| p.R351Q | STAD | 1 |
| p.G264E | SKCM | 1 |
| p.E643K | ESCA | 1 |
| p.W389* | STAD | 1 |
| p.L564R | BLCA | 1 |
| p.P26L | SKCM | 1 |
| p.R251W | STAD | 1 |
| p.G57R | LGG | 1 |
| p.M427I | HNSC | 1 |
| p.R311W | PRAD | 1 |
| p.S105F | SKCM | 1 |
| p.V671A | STAD | 1 |
| p.V134I | LGG | 1 |
| p.A131V | STAD | 1 |
| p.R365Q | SKCM | 1 |
| p.R92W | SKCM | 1 |
| p.E490G | STAD | 1 |
| p.F231L | UCEC | 1 |
| p.P216S | SKCM | 1 |
| p.S584I | LUAD | 1 |
| p.A321V | SARC | 1 |
| p.V233I | STAD | 1 |
| p.P124T | LGG | 1 |
| p.Q197* | LUAD | 1 |
| p.R184C | PAAD | 1 |
| p.S640Y | DLBC | 1 |
| p.G662D | ESCA | 1 |
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| TissGeneCNV for CLCNKB |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CLCNKB |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA377618 | TNKS2-CLCNKB | chr10:93609803 | chr1:16372781 | |
| Chimerdb3.0 | ChiTaRs | NA | BF822523 | CLCNKB-ABHD2 | chr1:16377433 | chr15:89742663 |
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| TissGeneNet for CLCNKB |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CLCNKB |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CLCNKB |
| TissGeneDrug for CLCNKB |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CLCNKB |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004775 | Bartter Disease | 23 | BeFree,CTD_human,LHGDN |
| umls:C1846343 | Bartter syndrome, type 3 | 12 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C0020538 | Hypertensive disease | 7 | BeFree,GAD,LHGDN |
| umls:C0085580 | Essential Hypertension | 6 | BeFree |
| umls:C0268450 | Gitelman Syndrome | 5 | BeFree,ORPHANET |
| umls:C0018784 | Sensorineural Hearing Loss (disorder) | 3 | BeFree |
| umls:C0022658 | Kidney Diseases | 3 | BeFree |
| umls:C0020599 | Hypocalciuria | 2 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree |
| umls:C0155552 | Hearing Loss, Mixed Conductive-Sensorineural | 2 | BeFree |
| umls:C0001126 | Renal tubular acidosis | 1 | BeFree |
| umls:C0020438 | Hypercalciuria | 1 | BeFree |
| umls:C0027709 | Nephrocalcinosis | 1 | BeFree |
| umls:C0085570 | Hypokalemic alkalosis | 1 | BeFree |
| umls:C0162283 | Nephrogenic Diabetes Insipidus | 1 | BeFree |
| umls:C0271561 | Somatotropin deficiency | 1 | BeFree |
| umls:C0339789 | Congenital deafness | 1 | BeFree |
| umls:C1384514 | Conn Syndrome | 1 | BeFree |
| umls:C3714796 | Isolated somatotropin deficiency | 1 | BeFree |
| umls:C1563705 | Nephrogenic Diabetes Insipidus, Type I | 0 | MGD |
| umls:C1846344 | Bartter Syndrome, Type 3, with Hypocalciuria | 0 | CLINVAR |
| umls:C1865270 | BARTTER SYNDROME, TYPE 4A | 0 | CTD_human |
| umls:C2751312 | BARTTER SYNDROME, TYPE 4B | 0 | CLINVAR |
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