TissGeneSummary for ADH1A |
Gene summary |
Basic gene information | Gene symbol | ADH1A |
Gene name | alcohol dehydrogenase 1A (class I), alpha polypeptide | |
Synonyms | ADH1 | |
Cytomap | UCSC genome browser: 4q23 | |
Type of gene | protein-coding | |
RefGenes | NM_000667.3, | |
Description | ADH, alpha subunitalcohol dehydrogenase 1 (class I), alpha polypeptidealcohol dehydrogenase 1Aalcohol dehydrogenase subunit alphaaldehyde reductase | |
Modification date | 20141207 | |
dbXrefs | MIM : 103700 | |
HGNC : HGNC | ||
Ensembl : ENSG00000187758 | ||
HPRD : 00063 | ||
Vega : OTTHUMG00000131026 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADH1A | |
BioGPS: 124 | ||
Pathway | NCI Pathway Interaction Database: ADH1A | |
KEGG: ADH1A | ||
REACTOME: ADH1A | ||
Pathway Commons: ADH1A | ||
Context | iHOP: ADH1A | |
ligand binding site mutation search in PubMed: ADH1A | ||
UCL Cancer Institute: ADH1A | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of ADH1A | Distant HNF1 site as a master control for the human class I alcohol dehydrogenase gene expression. Su JS, Tsai TF, Chang HM, Chao KM, Su TS, Tsai SF. J Biol Chem. 2006 Jul 21;281(29):19809-21. Epub 2006 May 4. (pmid:16675441) go to article | |
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADH1A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.198541364 | 4.516825303 | -4.715366667 | 7.56E-33 | 6.08E-31 |
KIRP | -0.875400494 | 2.052946381 | -2.928346875 | 1.08E-18 | 5.63E-17 |
BRCA | 0.557553837 | 5.332916995 | -4.775363158 | 1.13E-43 | 4.55E-42 |
COAD | -0.093890157 | 3.705571381 | -3.799461538 | 3.19E-17 | 4.11E-15 |
HNSC | -1.124294898 | 0.8696958 | -1.993990698 | 2.85E-09 | 4.06E-08 |
LIHC | 10.83696138 | 13.77568738 | -2.938726 | 2.38E-10 | 2.97E-09 |
THCA | -1.2871515 | 0.778409517 | -2.065561017 | 1.51E-24 | 2.09E-22 |
KICH | -0.258146619 | 2.733797381 | -2.991944 | 3.17E-09 | 1.82E-08 |
KIRC | -0.386588341 | 2.762199159 | -3.1487875 | 7.29E-32 | 1.62E-30 |
LUAD | 1.148023105 | 4.628138623 | -3.480115517 | 4.66E-22 | 1.23E-20 |
BLCA | -0.828541777 | 3.131163486 | -3.959705263 | 2.70E-11 | 1.00E-08 |
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TissGene-miRNA for ADH1A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADH1A |
TissGeneSNV for ADH1A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R38C | SKCM | 4 |
p.S342L | SKCM | 4 |
p.E257K | SKCM | 4 |
p.S165L | SKCM | 2 |
p.H52N | LUAD | 2 |
p.E235K | SKCM | 1 |
p.A222V | UCEC | 1 |
p.E17K | SKCM | 1 |
p.L320F | SKCM | 1 |
p.T146I | SKCM | 1 |
p.S178* | HNSC | 1 |
p.H68Y | SKCM | 1 |
p.V77A | SKCM | 1 |
p.S303X | SKCM | 1 |
p.G202R | SKCM | 1 |
p.V42M | SKCM | 1 |
p.G317R | BLCA | 1 |
p.V53M | COAD | 1 |
p.E69V | PRAD | 1 |
p.T49K | LUAD | 1 |
p.E327D | BLCA | 1 |
p.L124M | GBM | 1 |
p.T275I | SKCM | 1 |
p.Y150* | LUAD | 1 |
p.S266L | SKCM | 1 |
p.W315X | SKCM | 1 |
p.I221F | STAD | 1 |
p.S23F | SKCM | 1 |
p.I161V | HNSC | 1 |
p.D361H | BLCA | 1 |
p.E28Q | LUAD | 1 |
p.A222V | PAAD | 1 |
p.G359E | SKCM | 1 |
p.E155K | SKCM | 1 |
p.P306S | SKCM | 1 |
p.P166T | LUSC | 1 |
p.V74M | LGG | 1 |
p.F141L | LIHC | 1 |
p.V59L | PAAD | 1 |
p.R38C | GBM | 1 |
p.M258I | SKCM | 1 |
p.P107L | BLCA | 1 |
p.G45E | SKCM | 1 |
p.G317E | BLCA | 1 |
p.D335N | SKCM | 1 |
p.S303* | SKCM | 1 |
p.P107L | STAD | 1 |
p.R38C | UCEC | 1 |
p.W315* | SKCM | 1 |
p.Q97R | PAAD | 1 |
p.G180R | BRCA | 1 |
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TissGeneCNV for ADH1A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADH1A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ADH1A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADH1A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADH1A |
TissGeneDrug for ADH1A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADH1A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001973 | Alcoholic Intoxication, Chronic | 5 | BeFree,GAD |
umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
umls:C0038580 | Substance Dependence | 2 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
umls:C0745103 | Hyperlipoproteinemia Type IIa | 2 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0003944 | As If Personality | 1 | GAD |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0010068 | Coronary heart disease | 1 | BeFree |
umls:C0020438 | Hypercalciuria | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0221253 | Xanthoma tendinosum | 1 | BeFree |
umls:C0342345 | Hypoparathyroidism - autosomal dominant | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C0700095 | Central neuroblastoma | 1 | BeFree |
umls:C0877008 | Enzyme inhibition disorder | 1 | BeFree |
umls:C1510472 | Drug Dependence | 1 | BeFree,GAD |
umls:C1527249 | Colorectal Cancer | 1 | GAD |
umls:C2239176 | Liver carcinoma | 1 | BeFree |