TissGeneSummary for CNGA1 |
Gene summary |
Basic gene information | Gene symbol | CNGA1 |
Gene name | cyclic nucleotide gated channel alpha 1 | |
Synonyms | CNCG|CNCG1|CNG-1|CNG1|RCNC1|RCNCa|RCNCalpha|RP49 | |
Cytomap | UCSC genome browser: 4p12 | |
Type of gene | protein-coding | |
RefGenes | NM_000087.3, NM_001142564.1, | |
Description | CNG channel alpha-1cGMP-gated cation channel alpha-1cyclic nucleotide-gated cation channel 1cyclic nucleotide-gated channel alpha-1cyclic nucleotide-gated channel, photoreceptorinterleukin-1 homologuerod photoreceptor cGMP-gated channel subunit alph | |
Modification date | 20141219 | |
dbXrefs | MIM : 123825 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198515 | ||
HPRD : 00445 | ||
Vega : OTTHUMG00000160668 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CNGA1 | |
BioGPS: 1259 | ||
Pathway | NCI Pathway Interaction Database: CNGA1 | |
KEGG: CNGA1 | ||
REACTOME: CNGA1 | ||
Pathway Commons: CNGA1 | ||
Context | iHOP: CNGA1 | |
ligand binding site mutation search in PubMed: CNGA1 | ||
UCL Cancer Institute: CNGA1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LiverEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHCUVM | |
Reference showing the relevant tissue of CNGA1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CNGA1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 2.673050186 | 4.984482186 | -2.311432 | 1.18E-07 | 8.14E-07 |
BRCA | -0.787535849 | 1.4786738 | -2.266209649 | 1.13E-18 | 7.30E-18 |
COAD | 0.611101263 | 2.36199357 | -1.750892308 | 1.35E-05 | 6.02E-05 |
LUAD | -0.405371814 | -1.553989056 | 1.148617241 | 1.15E-05 | 3.35E-05 |
HNSC | 0.297684 | 1.547132837 | -1.249448837 | 3.73E-06 | 2.41E-05 |
KIRP | -1.873290564 | 2.301253186 | -4.17454375 | 3.04E-17 | 1.31E-15 |
KIRC | 0.08077263 | 2.830364297 | -2.749591667 | 1.18E-23 | 1.25E-22 |
KICH | 1.481016186 | 2.700912186 | -1.219896 | 0.00649 | 0.012142581 |
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TissGene-miRNA for CNGA1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CNGA1 |
TissGeneSNV for CNGA1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R698Q | SKCM | 3 |
p.S134F | SKCM | 2 |
p.R629* | SKCM | 2 |
p.G623E | SKCM | 2 |
p.R629Q | SKCM | 2 |
p.E127K | SKCM | 2 |
p.K348N | SKCM | 1 |
p.R493* | SKCM | 1 |
p.I461N | HNSC | 1 |
p.M70I | SKCM | 1 |
p.I380F | LUAD | 1 |
p.M103K | LUAD | 1 |
p.K208N | UCEC | 1 |
p.V517F | LUSC | 1 |
p.I506F | LGG | 1 |
p.D283N | UCEC | 1 |
p.D609N | UCEC | 1 |
p.R478H | HNSC | 1 |
p.S279F | BLCA | 1 |
p.G701E | SKCM | 1 |
p.R287Q | SKCM | 1 |
p.T729N | GBM | 1 |
p.P364Q | CHOL | 1 |
p.G143V | SKCM | 1 |
p.F423L | STAD | 1 |
p.G231E | SKCM | 1 |
p.D283N | STAD | 1 |
p.M374V | LIHC | 1 |
p.P153H | SKCM | 1 |
p.D318E | TGCT | 1 |
p.R547H | HNSC | 1 |
p.K661E | STAD | 1 |
p.I469L | STAD | 1 |
p.K417N | SKCM | 1 |
p.D118N | COAD | 1 |
p.D194N | SKCM | 1 |
p.H539N | SKCM | 1 |
p.S65F | SKCM | 1 |
p.D215N | SKCM | 1 |
p.R712Q | UCEC | 1 |
p.L293R | KIRC | 1 |
p.D372N | HNSC | 1 |
p.D441N | SKCM | 1 |
p.R478H | STAD | 1 |
p.E700V | KIRC | 1 |
p.R629Q | UCEC | 1 |
p.L293V | LUAD | 1 |
p.I713M | SKCM | 1 |
p.R640S | STAD | 1 |
p.I400L | STAD | 1 |
p.L224V | LUAD | 1 |
p.A477E | BRCA | 1 |
p.M468I | SKCM | 1 |
p.R280G | LUAD | 1 |
p.Y247D | BLCA | 1 |
p.P502T | HNSC | 1 |
p.K497I | UCEC | 1 |
p.V477A | STAD | 1 |
p.C257R | LUAD | 1 |
p.K661N | UCEC | 1 |
p.E223V | KIRC | 1 |
p.R280C | COAD | 1 |
p.A415D | SKCM | 1 |
p.E125D | UCEC | 1 |
p.K221N | UCEC | 1 |
p.R514Q | COAD | 1 |
p.R218Q | SKCM | 1 |
p.I575F | LGG | 1 |
p.K730E | STAD | 1 |
p.L650F | ESCA | 1 |
p.E656D | UCEC | 1 |
p.N243S | SKCM | 1 |
p.S230L | BLCA | 1 |
p.D186Y | SARC | 1 |
p.R712Q | ESCA | 1 |
p.R413I | COAD | 1 |
p.N365K | ESCA | 1 |
p.G162E | SKCM | 1 |
p.R287Q | LUSC | 1 |
p.P620S | SKCM | 1 |
p.M1I | COAD | 1 |
p.H470N | SKCM | 1 |
p.R371K | SKCM | 1 |
p.R547H | ESCA | 1 |
p.R344C | COAD | 1 |
p.K6N | READ | 1 |
p.E58K | SKCM | 1 |
p.R349G | LUAD | 1 |
p.D441N | HNSC | 1 |
p.K505T | UCS | 1 |
p.F354I | STAD | 1 |
p.P89S | ESCA | 1 |
p.G632E | SKCM | 1 |
p.R712* | PRAD | 1 |
p.D214N | STAD | 1 |
p.L645F | LUSC | 1 |
p.R413H | GBM | 1 |
p.F492L | STAD | 1 |
p.G433D | UCEC | 1 |
p.V546A | STAD | 1 |
p.E559Q | LUSC | 1 |
p.P571T | HNSC | 1 |
p.V217I | STAD | 1 |
p.R712Q | BLCA | 1 |
p.E121K | READ | 1 |
p.K204T | UCEC | 1 |
p.D146N | SKCM | 1 |
p.R440K | SKCM | 1 |
p.R424X | SKCM | 1 |
p.G668R | SKCM | 1 |
p.F285I | STAD | 1 |
p.S124L | SKCM | 1 |
p.R343M | UCEC | 1 |
p.Q262* | SKCM | 1 |
p.P689S | SKCM | 1 |
p.E666K | SKCM | 1 |
p.D372N | SKCM | 1 |
p.A626S | LUAD | 1 |
p.A751E | LUAD | 1 |
p.M399I | SKCM | 1 |
p.S348F | BLCA | 1 |
p.N312S | SKCM | 1 |
p.E220D | LUAD | 1 |
p.F159S | UCEC | 1 |
p.P145Q | THYM | 1 |
p.L461I | OV | 1 |
p.A346D | SKCM | 1 |
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TissGeneCNV for CNGA1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CNGA1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CNGA1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CNGA1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CNGA1 |
TissGeneDrug for CNGA1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CNGA1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0035334 | Retinitis Pigmentosa | 4 | BeFree,CTD_human,LHGDN,ORPHANET |
umls:C0339526 | Autosomal recessive retinitis pigmentosa | 2 | BeFree |
umls:C0035309 | Retinal Diseases | 1 | GAD |
umls:C3151059 | RETINITIS PIGMENTOSA 49 | 1 | CLINVAR,UNIPROT |