TissGeneSummary for FBXO27 |
Gene summary |
Basic gene information | Gene symbol | FBXO27 |
Gene name | F-box protein 27 | |
Synonyms | FBG5|Fbx27 | |
Cytomap | UCSC genome browser: 19q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_178820.3, | |
Description | F-box only protein 27F-box protein FBG5F-box/G-domain protein 5 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609099 | |
HGNC : HGNC | ||
Ensembl : ENSG00000161243 | ||
HPRD : 16440 | ||
Vega : OTTHUMG00000182719 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FBXO27 | |
BioGPS: 126433 | ||
Pathway | NCI Pathway Interaction Database: FBXO27 | |
KEGG: FBXO27 | ||
REACTOME: FBXO27 | ||
Pathway Commons: FBXO27 | ||
Context | iHOP: FBXO27 | |
ligand binding site mutation search in PubMed: FBXO27 | ||
UCL Cancer Institute: FBXO27 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADSKCM | |
Reference showing the relevant tissue of FBXO27 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FBXO27 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -1.173474204 | 0.125929185 | -1.29940339 | 7.40E-13 | 6.80E-12 |
COAD | -3.186867816 | -1.419437047 | -1.767430769 | 1.11E-05 | 5.05E-05 |
LUSC | 2.369641083 | 0.263250887 | 2.106390196 | 6.74E-10 | 2.36E-09 |
STAD | -1.114984162 | 0.810218963 | -1.925203125 | 6.35E-05 | 0.000529764 |
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TissGene-miRNA for FBXO27 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FBXO27 |
TissGeneSNV for FBXO27 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R281C | SKCM | 2 |
p.F219L | SKCM | 1 |
p.A211T | SKCM | 1 |
p.R281C | PAAD | 1 |
p.F219L | BLCA | 1 |
p.I244M | BLCA | 1 |
p.V278M | ESCA | 1 |
p.Q130E | KIRP | 1 |
p.D134Y | BLCA | 1 |
p.D224H | HNSC | 1 |
p.A194D | OV | 1 |
p.W160* | HNSC | 1 |
p.D134N | HNSC | 1 |
p.R279Q | COAD | 1 |
p.D134N | KIRC | 1 |
p.Q165H | BLCA | 1 |
p.S252Y | COAD | 1 |
p.V206I | STAD | 1 |
p.R203X | LIHC | 1 |
p.Q213R | BRCA | 1 |
p.R203* | LIHC | 1 |
p.V137G | STAD | 1 |
p.W175* | PRAD | 1 |
p.Q130* | ACC | 1 |
p.Q151* | BLCA | 1 |
p.Q130X | ACC | 1 |
p.G265S | COAD | 1 |
p.L216I | UCS | 1 |
p.K163N | LUSC | 1 |
p.E170K | LUSC | 1 |
p.R183M | THYM | 1 |
p.P98H | COAD | 1 |
p.F253V | BRCA | 1 |
p.W229* | LUAD | 1 |
p.P225S | SKCM | 1 |
p.G120C | LUAD | 1 |
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TissGeneCNV for FBXO27 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FBXO27 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ225001 | FBXO27-FBXO27 | chr19:39515912 | chr19:39515764 |
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TissGeneNet for FBXO27 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FBXO27 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FBXO27 |
TissGeneDrug for FBXO27 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FBXO27 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |