TissGeneSummary for WDR64 |
Gene summary |
Basic gene information | Gene symbol | WDR64 |
Gene name | WD repeat domain 64 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 1q43 | |
Type of gene | protein-coding | |
RefGenes | NM_144625.4, | |
Description | WD repeat-containing protein 64 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000162843 | ||
HPRD : 13412 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_WDR64 | |
BioGPS: 128025 | ||
Pathway | NCI Pathway Interaction Database: WDR64 | |
KEGG: WDR64 | ||
REACTOME: WDR64 | ||
Pathway Commons: WDR64 | ||
Context | iHOP: WDR64 | |
ligand binding site mutation search in PubMed: WDR64 | ||
UCL Cancer Institute: WDR64 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of WDR64 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for WDR64 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for WDR64 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for WDR64 |
TissGeneSNV for WDR64 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D918Y | BLCA | 2 |
p.S867Y | STAD | 1 |
p.A340V | UCEC | 1 |
p.K1035R | KIRP | 1 |
p.I296V | UCEC | 1 |
p.L462V | LUAD | 1 |
p.M419L | LUSC | 1 |
p.Q915R | BLCA | 1 |
p.R75H | COAD | 1 |
p.R952W | COAD | 1 |
p.R864H | COAD | 1 |
p.I164L | UCEC | 1 |
p.E976K | LUSC | 1 |
p.D441N | UCEC | 1 |
p.F202V | CESC | 1 |
p.N464S | SKCM | 1 |
p.T638A | LUAD | 1 |
p.L1071Q | LUSC | 1 |
p.Q253K | LUAD | 1 |
p.L661F | LUAD | 1 |
p.L963V | HNSC | 1 |
p.R864H | GBM | 1 |
p.V891L | LUAD | 1 |
p.L488I | LUAD | 1 |
p.V382I | ESCA | 1 |
p.A620S | UCEC | 1 |
p.S385Y | LUSC | 1 |
p.E483* | LUAD | 1 |
p.G341V | SARC | 1 |
p.P624L | SKCM | 1 |
p.R122Q | UCEC | 1 |
p.R177Q | UCEC | 1 |
p.P1067Q | UCEC | 1 |
p.L594P | LIHC | 1 |
p.S41F | UCEC | 1 |
p.S302L | SKCM | 1 |
p.S59X | KIRP | 1 |
p.F1075S | SKCM | 1 |
p.F499V | SKCM | 1 |
p.S420Y | STAD | 1 |
p.I187M | SARC | 1 |
p.R545T | HNSC | 1 |
p.R1052H | PAAD | 1 |
p.G1043R | SKCM | 1 |
p.L661F | READ | 1 |
p.G385R | OV | 1 |
p.S825T | SARC | 1 |
p.D72H | BRCA | 1 |
p.R177X | DLBC | 1 |
p.R1057Q | SKCM | 1 |
p.R712H | COAD | 1 |
p.D67Y | UCEC | 1 |
p.L538V | BRCA | 1 |
p.V317I | UCEC | 1 |
p.H852Y | ESCA | 1 |
p.R553C | PRAD | 1 |
p.N1064K | COAD | 1 |
p.R611T | BLCA | 1 |
p.N464H | LUAD | 1 |
p.Q533K | LUAD | 1 |
p.M281V | LUAD | 1 |
p.R1052S | LUAD | 1 |
p.Y51* | UCEC | 1 |
p.V1031I | STAD | 1 |
p.G487E | SKCM | 1 |
p.Q565L | LUSC | 1 |
p.P171R | OV | 1 |
p.F1075V | SKCM | 1 |
p.V1031I | COAD | 1 |
p.G360E | LUSC | 1 |
p.V999M | STAD | 1 |
p.I473M | BLCA | 1 |
p.R239I | UCEC | 1 |
p.S986F | MESO | 1 |
p.R456Q | SKCM | 1 |
p.R991* | SKCM | 1 |
p.S475Y | LGG | 1 |
p.D471Y | UCEC | 1 |
p.M11K | KIRC | 1 |
p.V584I | STAD | 1 |
p.G754C | ESCA | 1 |
p.R4G | LUAD | 1 |
p.G541E | SKCM | 1 |
p.M958I | SKCM | 1 |
p.R556K | BRCA | 1 |
p.I382T | LUAD | 1 |
p.M298I | LUAD | 1 |
p.V317G | UCEC | 1 |
p.S386T | LUAD | 1 |
p.I429V | LUAD | 1 |
p.D413N | READ | 1 |
p.R391W | SKCM | 1 |
p.R442T | LUAD | 1 |
p.R991X | LIHC | 1 |
p.R461* | UCEC | 1 |
p.D531N | UCEC | 1 |
p.S385F | SKCM | 1 |
p.R1052H | GBM | 1 |
p.T430M | SKCM | 1 |
p.R1059K | SKCM | 1 |
p.Y491C | BLCA | 1 |
p.W863X | COAD | 1 |
p.D18Y | UCEC | 1 |
p.V444L | LUAD | 1 |
p.D592N | UCEC | 1 |
p.E1004K | SKCM | 1 |
p.R992T | HNSC | 1 |
p.I662T | LUAD | 1 |
p.S385F | LGG | 1 |
p.P641L | SKCM | 1 |
p.F491L | STAD | 1 |
p.L440S | LUSC | 1 |
p.E455D | LUAD | 1 |
p.S383I | LUAD | 1 |
p.S287L | HNSC | 1 |
p.F938L | STAD | 1 |
p.F1025C | PAAD | 1 |
p.R647Q | COAD | 1 |
p.E376V | THYM | 1 |
p.E878X | READ | 1 |
p.E268* | BRCA | 1 |
p.R1057L | THYM | 1 |
p.E495* | SARC | 1 |
p.S886C | PRAD | 1 |
p.G601C | BRCA | 1 |
p.S432T | LIHC | 1 |
p.L349F | LUAD | 1 |
p.D652H | BLCA | 1 |
p.D102Y | CESC | 1 |
p.G833R | SARC | 1 |
p.P988L | SKCM | 1 |
p.G1040S | SKCM | 1 |
p.H771Y | COAD | 1 |
p.M437I | PRAD | 1 |
p.A370S | MESO | 1 |
p.Q636* | CESC | 1 |
p.K266N | COAD | 1 |
p.H452N | LUAD | 1 |
p.E199D | COAD | 1 |
p.M578I | LUAD | 1 |
p.P624S | SKCM | 1 |
p.G792E | COAD | 1 |
p.E488* | UCEC | 1 |
p.L516V | HNSC | 1 |
p.P496S | COAD | 1 |
p.R1058T | BLCA | 1 |
p.S936R | ESCA | 1 |
p.V37I | UCEC | 1 |
p.M427I | LUAD | 1 |
p.L219F | SARC | 1 |
p.S355G | LUAD | 1 |
p.R864C | LIHC | 1 |
p.R75C | COAD | 1 |
p.A143V | UCEC | 1 |
p.T163A | UCEC | 1 |
p.L349F | KIRC | 1 |
p.P620Q | UCEC | 1 |
p.V876E | LUAD | 1 |
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TissGeneCNV for WDR64 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for WDR64 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for WDR64 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for WDR64 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for WDR64 |
TissGeneDrug for WDR64 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for WDR64 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0026769 | Multiple Sclerosis | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |