TissGeneSummary for SPATA17 |
Gene summary |
Basic gene information | Gene symbol | SPATA17 |
Gene name | spermatogenesis associated 17 | |
Synonyms | IQCH|MSRG-11|MSRG11 | |
Cytomap | UCSC genome browser: 1q41 | |
Type of gene | protein-coding | |
RefGenes | NM_138796.3, | |
Description | IQ motif containing Hspermatogenesis-associated protein 17spermatogenesis-related protein 11 | |
Modification date | 20141218 | |
dbXrefs | MIM : 611032 | |
HGNC : HGNC | ||
HPRD : 14039 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPATA17 | |
BioGPS: 128153 | ||
Pathway | NCI Pathway Interaction Database: SPATA17 | |
KEGG: SPATA17 | ||
REACTOME: SPATA17 | ||
Pathway Commons: SPATA17 | ||
Context | iHOP: SPATA17 | |
ligand binding site mutation search in PubMed: SPATA17 | ||
UCL Cancer Institute: SPATA17 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SPATA17 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPATA17 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 0.55706628 | 1.58651628 | -1.02945 | 2.38E-10 | 8.13E-10 |
THCA | 0.492311383 | 1.793584264 | -1.301272881 | 2.49E-17 | 4.92E-16 |
BRCA | 1.728653414 | -0.128679919 | 1.857333333 | 2.94E-27 | 3.30E-26 |
KICH | -0.922469498 | 1.412702502 | -2.335172 | 0.000749 | 0.001652448 |
STAD | -0.374898998 | -1.974064623 | 1.599165625 | 1.98E-05 | 0.00020241 |
COAD | -0.526242267 | -1.788365344 | 1.262123077 | 3.74E-05 | 0.000150079 |
BLCA | 0.87358587 | -1.418066761 | 2.291652632 | 6.90E-06 | 0.000144248 |
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TissGene-miRNA for SPATA17 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPATA17 |
TissGeneSNV for SPATA17 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R108W | SKCM | 2 |
p.P227S | SKCM | 2 |
p.R254C | STAD | 2 |
p.R72K | CESC | 2 |
p.R49W | SKCM | 1 |
p.K172M | LIHC | 1 |
p.D289G | HNSC | 1 |
p.S297L | SKCM | 1 |
p.R183G | LIHC | 1 |
p.R183I | KIRC | 1 |
p.T3M | COAD | 1 |
p.T248S | LUAD | 1 |
p.D129N | ESCA | 1 |
p.R254H | BRCA | 1 |
p.S125L | LIHC | 1 |
p.R49W | READ | 1 |
p.G45* | UCEC | 1 |
p.R103* | ESCA | 1 |
p.E321* | KIRP | 1 |
p.P257L | SKCM | 1 |
p.K209E | ESCA | 1 |
p.R44Q | LUAD | 1 |
p.Q40H | HNSC | 1 |
p.I247T | BLCA | 1 |
p.V81L | BRCA | 1 |
p.R202* | STAD | 1 |
p.R202Q | READ | 1 |
p.E321Q | BLCA | 1 |
p.R97S | THYM | 1 |
p.E321X | KIRP | 1 |
p.R324* | STAD | 1 |
p.R254H | COAD | 1 |
p.I305T | COAD | 1 |
p.I52V | SARC | 1 |
p.K300N | COAD | 1 |
p.R263W | SARC | 1 |
p.R163X | SKCM | 1 |
p.S348* | BLCA | 1 |
p.D269N | STAD | 1 |
p.W102R | COAD | 1 |
p.K73Q | SKCM | 1 |
p.Q80K | GBM | 1 |
p.R224H | PAAD | 1 |
p.R202X | STAD | 1 |
p.R163* | SKCM | 1 |
p.T3R | BLCA | 1 |
p.R324* | LGG | 1 |
p.P204H | LUAD | 1 |
p.R324X | STAD | 1 |
p.R108L | LUAD | 1 |
p.L55I | PAAD | 1 |
p.G351V | UCEC | 1 |
p.W283L | LUAD | 1 |
p.P316L | SKCM | 1 |
p.K148N | LUSC | 1 |
p.I61S | UCEC | 1 |
p.Y167C | STAD | 1 |
p.P204R | HNSC | 1 |
p.E276Q | LUAD | 1 |
p.T261M | COAD | 1 |
p.G358A | LUAD | 1 |
p.Q99K | ESCA | 1 |
p.E249K | COAD | 1 |
p.K349T | PAAD | 1 |
p.F344L | KIRC | 1 |
p.N92K | CESC | 1 |
p.P188L | LUSC | 1 |
p.V250I | SARC | 1 |
p.K205N | UCEC | 1 |
p.D129Y | HNSC | 1 |
p.V124I | UCEC | 1 |
p.M87I | HNSC | 1 |
p.R254C | LIHC | 1 |
p.Q8K | STAD | 1 |
p.E155* | LUAD | 1 |
p.K142N | DLBC | 1 |
p.A50T | LIHC | 1 |
p.E145G | LGG | 1 |
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TissGeneCNV for SPATA17 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPATA17 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | CB243437 | SPATA17-SPATA17 | chr1:218040492 | chr1:217975060 | |
Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7077-01A | ZNF10-SPATA17 | 5'UTR-CDS | chr12:133707339 | chr1:218036115 |
Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7077-01A | ZNF10-SPATA17 | 5'UTR-CDS | chr12:133707598 | chr1:218036114 |
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TissGeneNet for SPATA17 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPATA17 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPATA17 |
TissGeneDrug for SPATA17 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPATA17 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0003125 | Anorexia Nervosa | 1 | GAD |
umls:C0004509 | Azoospermia | 1 | BeFree |
umls:C0021364 | Male infertility | 1 | GAD |