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| TissGeneSummary for ADH6 |
 Gene summary |
| Basic gene information | Gene symbol | ADH6 |
| Gene name | alcohol dehydrogenase 6 (class V) | |
| Synonyms | ADH-5 | |
| Cytomap | UCSC genome browser: 4q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000672.3, NM_001102470.1, | |
| Description | alcohol dehydrogenase 6aldehyde reductase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 103735 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000172955 | ||
| HPRD : 00067 | ||
| Vega : OTTHUMG00000131024 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ADH6 | |
| BioGPS: 130 | ||
| Pathway | NCI Pathway Interaction Database: ADH6 | |
| KEGG: ADH6 | ||
| REACTOME: ADH6 | ||
| Pathway Commons: ADH6 | ||
| Context | iHOP: ADH6 | |
| ligand binding site mutation search in PubMed: ADH6 | ||
| UCL Cancer Institute: ADH6 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of ADH6 | DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma. Udali S, Guarini P, Ruzzenente A, Ferrarini A, Guglielmi A, Lotto V, Tononi P, Pattini P, Moruzzi S, Campagnaro T, Conci S, Olivieri O, Corrocher R, Delledonne M, Choi SW, Friso S. Clin Epigenetics. 2015 Apr 14;7:43. doi: 10.1186/s13148-015-0077-1. eCollection 2015. (pmid:25945129) go to article | |
| Description by TissGene annotations | Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006069 | ethanol oxidation | 1755855 | GO:0045471 | response to ethanol | 1755855 | GO:0006069 | ethanol oxidation | 1755855 | GO:0045471 | response to ethanol | 1755855 |
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| TissGeneExp for ADH6 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 9.219904545 | 11.48003654 | -2.260132 | 3.21E-10 | 3.87E-09 |
| LUSC | -0.776844004 | 0.913201094 | -1.690045098 | 4.63E-08 | 1.35E-07 |
| COAD | 3.690440083 | 6.067182391 | -2.376742308 | 1.56E-08 | 1.32E-07 |
| KICH | 1.297724545 | 4.989700545 | -3.691976 | 0.000225 | 0.000550388 |
| KIRP | 3.689284795 | 6.512153545 | -2.82286875 | 3.75E-05 | 0.000140594 |
| KIRC | 3.748252156 | 5.617154934 | -1.868902778 | 5.11E-05 | 0.000111613 |
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| TissGene-miRNA for ADH6 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ADH6 |
| TissGeneSNV for ADH6 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R38C | SKCM | 3 |
| p.E155K | SKCM | 3 |
| p.G81R | SKCM | 1 |
| p.G135E | SKCM | 1 |
| p.D335H | BRCA | 1 |
| p.A165T | UCEC | 1 |
| p.V41I | SKCM | 1 |
| p.E36K | SKCM | 1 |
| p.P31Q | LUAD | 1 |
| p.G202A | BLCA | 1 |
| p.G79A | STAD | 1 |
| p.S104Y | LUAD | 1 |
| p.H349Y | BLCA | 1 |
| p.S207F | SKCM | 1 |
| p.P64L | BLCA | 1 |
| p.A197V | SKCM | 1 |
| p.M363I | BLCA | 1 |
| p.G110S | SKCM | 1 |
| p.S23F | SKCM | 1 |
| p.E76K | LIHC | 1 |
| p.Q245E | BLCA | 1 |
| p.S145C | LGG | 1 |
| p.Y150* | HNSC | 1 |
| p.P31T | BLCA | 1 |
| p.T191N | UCS | 1 |
| p.K35N | UCEC | 1 |
| p.R313C | ESCA | 1 |
| p.V295A | STAD | 1 |
| p.S284F | SKCM | 1 |
| p.T259S | UCEC | 1 |
| p.K52E | UCEC | 1 |
| p.C47G | SKCM | 1 |
| p.L201M | LUAD | 1 |
| p.T348P | PCPG | 1 |
| p.E339D | UCEC | 1 |
| p.K248Q | LUAD | 1 |
| p.L351Q | LUAD | 1 |
| p.D260N | UCS | 1 |
| p.K355T | STAD | 1 |
| p.S318F | SKCM | 1 |
| p.S119P | SKCM | 1 |
| p.T128A | STAD | 1 |
| p.V75I | PRAD | 1 |
| p.R313H | PAAD | 1 |
| p.M363I | SKCM | 1 |
| p.F265L | LGG | 1 |
| p.V7A | THYM | 1 |
| p.G45R | BLCA | 1 |
| p.S286R | KIRP | 1 |
| p.I39K | KIRC | 1 |
| p.L123M | LUAD | 1 |
| p.T121P | COAD | 1 |
| p.S174R | LGG | 1 |
| p.L247F | KIRP | 1 |
| p.R370C | STAD | 1 |
| p.M51I | SKCM | 1 |
| p.I161M | COAD | 1 |
| p.C10Y | LUAD | 1 |
| p.R38C | UCEC | 1 |
| p.P250L | SKCM | 1 |
| p.E268* | CESC | 1 |
| p.R370H | UCEC | 1 |
| p.A30T | UCEC | 1 |
| p.F131C | STAD | 1 |
| p.T348I | PCPG | 1 |
| p.V190A | CHOL | 1 |
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| TissGeneCNV for ADH6 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ADH6 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | LGG | TCGA-HT-7472-01A | TET2-ADH6 | 5UTR-CDS | Chr4:106111662 | Chr4:100137419 |
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| TissGeneNet for ADH6 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| COAD (tumor) | COAD (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| KICH (tumor) | KICH (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| STAD (tumor) | STAD (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| THCA (tumor) | THCA (normal) |
| ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (tumor) | ADH6, HNF4A, RPS29, RSL1D1, ARRB1, RASSF5, HNF1A, TNIP1, KRAS, ANKRD17, RPAIN (normal) |
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| TissGeneProg for ADH6 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ADH6 |
| TissGeneDrug for ADH6 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ADH6 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 2 | BeFree,GAD |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
| umls:C0038580 | Substance Dependence | 1 | BeFree |
| umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | GAD |
| umls:C0877008 | Enzyme inhibition disorder | 1 | BeFree |
| umls:C1510472 | Drug Dependence | 1 | BeFree,GAD |
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