TissGeneSummary for TRIM71 |
Gene summary |
Basic gene information | Gene symbol | TRIM71 |
Gene name | tripartite motif containing 71, E3 ubiquitin protein ligase | |
Synonyms | LIN-41|LIN41 | |
Cytomap | UCSC genome browser: 3p22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001039111.1, | |
Description | E3 ubiquitin-protein ligase TRIM71abnormal cell LINeage LIN-41homolog of C. elegans Lin-41protein lin-41 homologtripartite motif-containing 71tripartite motif-containing protein 71 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TRIM71 | |
BioGPS: 131405 | ||
Pathway | NCI Pathway Interaction Database: TRIM71 | |
KEGG: TRIM71 | ||
REACTOME: TRIM71 | ||
Pathway Commons: TRIM71 | ||
Context | iHOP: TRIM71 | |
ligand binding site mutation search in PubMed: TRIM71 | ||
UCL Cancer Institute: TRIM71 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TRIM71 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TRIM71 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 0.583348517 | -0.947569483 | 1.530918 | 1.88E-05 | 7.47E-05 |
LUAD | 0.061419758 | 2.561776655 | -2.500356897 | 2.69E-19 | 4.83E-18 |
LUSC | -0.051720032 | 2.33018585 | -2.381905882 | 1.22E-17 | 1.05E-16 |
KIRP | 0.527908767 | 1.967677517 | -1.43976875 | 0.00863 | 0.019252199 |
KIRC | 0.446208072 | 1.499355294 | -1.053147222 | 0.000835 | 0.001587137 |
KICH | -0.671143483 | 0.688636517 | -1.35978 | 4.00E-04 | 0.00093094 |
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TissGene-miRNA for TRIM71 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-144-3p | MIMAT0000436 | 0.043 | -0.26 | 60 |
ACC | hsa-miR-26a-5p | MIMAT0000082 | 0.018 | -0.27 | 78 |
ACC | hsa-miR-26a-5p | MIMAT0000082 | 0.018 | -0.27 | 78 |
ACC | hsa-miR-181a-5p | MIMAT0000256 | 0.014 | -0.28 | 78 |
ACC | hsa-miR-181a-5p | MIMAT0000256 | 0.014 | -0.28 | 78 |
LUAD | hsa-miR-200b-3p | MIMAT0000318 | 0.022 | -0.3 | 60 |
LUAD | hsa-miR-429 | MIMAT0001536 | 0.0012 | -0.41 | 60 |
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TissGeneMut for TRIM71 |
TissGeneSNV for TRIM71 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A357V | COAD | 2 |
p.T38S | STAD | 2 |
p.S749F | SKCM | 2 |
p.R336Q | SKCM | 1 |
p.G304V | SARC | 1 |
p.A247V | STAD | 1 |
p.R807C | STAD | 1 |
p.R625H | UCEC | 1 |
p.R336* | GBM | 1 |
p.S3L | KIRP | 1 |
p.R796H | HNSC | 1 |
p.D705N | SKCM | 1 |
p.R807H | COAD | 1 |
p.R864X | SKCM | 1 |
p.R629P | ESCA | 1 |
p.R843C | LUSC | 1 |
p.V418M | COAD | 1 |
p.Y510X | SKCM | 1 |
p.G47R | GBM | 1 |
p.A638T | STAD | 1 |
p.E572Q | BLCA | 1 |
p.R655* | BLCA | 1 |
p.R378C | UCEC | 1 |
p.K581M | PRAD | 1 |
p.Q725X | SKCM | 1 |
p.G493C | READ | 1 |
p.R807C | UCEC | 1 |
p.R649Q | COAD | 1 |
p.D852Y | LUAD | 1 |
p.N573S | UCEC | 1 |
p.P554L | SKCM | 1 |
p.D291G | UCEC | 1 |
p.L408P | ESCA | 1 |
p.M460V | COAD | 1 |
p.Q631* | SKCM | 1 |
p.L828M | STAD | 1 |
p.A52V | STAD | 1 |
p.A801S | LUAD | 1 |
p.R448W | STAD | 1 |
p.G731C | ACC | 1 |
p.E344K | LGG | 1 |
p.R864* | SKCM | 1 |
p.R864Q | SKCM | 1 |
p.E344K | SKCM | 1 |
p.R864X | COAD | 1 |
p.S310R | KIRP | 1 |
p.L275P | SKCM | 1 |
p.S749Y | BLCA | 1 |
p.D673G | LIHC | 1 |
p.R676H | LGG | 1 |
p.R625H | PRAD | 1 |
p.Q466E | BLCA | 1 |
p.A369V | ESCA | 1 |
p.A251V | STAD | 1 |
p.D283H | BLCA | 1 |
p.V447M | STAD | 1 |
p.G658D | LIHC | 1 |
p.R782H | GBM | 1 |
p.H197Y | PAAD | 1 |
p.R378S | KIRP | 1 |
p.Q315* | SKCM | 1 |
p.R723Q | HNSC | 1 |
p.G257R | STAD | 1 |
p.Q725* | SKCM | 1 |
p.K581N | UCEC | 1 |
p.S33P | STAD | 1 |
p.R322Q | UCEC | 1 |
p.E217K | SKCM | 1 |
p.C278S | STAD | 1 |
p.V418M | HNSC | 1 |
p.R299S | PRAD | 1 |
p.R796C | PRAD | 1 |
p.S474F | SKCM | 1 |
p.F265Y | LUAD | 1 |
p.Q454* | BLCA | 1 |
p.G846S | BRCA | 1 |
p.A811V | UCEC | 1 |
p.D852E | LUAD | 1 |
p.D492N | LUAD | 1 |
p.G788D | SARC | 1 |
p.A23G | LUAD | 1 |
p.V459L | KIRC | 1 |
p.R817W | LUAD | 1 |
p.R629C | STAD | 1 |
p.S786L | SKCM | 1 |
p.R796C | SKCM | 1 |
p.T719M | STAD | 1 |
p.Y510* | SKCM | 1 |
p.N407H | HNSC | 1 |
p.R676C | BLCA | 1 |
p.R553X | COAD | 1 |
p.A53G | STAD | 1 |
p.Q315X | SKCM | 1 |
p.G694E | LUAD | 1 |
p.D748V | COAD | 1 |
p.L383R | COAD | 1 |
p.S648F | BLCA | 1 |
p.E740K | LGG | 1 |
p.M820I | BRCA | 1 |
p.S541T | BLCA | 1 |
p.D457N | STAD | 1 |
p.F505L | BRCA | 1 |
p.E822V | SKCM | 1 |
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TissGeneCNV for TRIM71 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TRIM71 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TRIM71 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TRIM71 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TRIM71 |
TissGeneDrug for TRIM71 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TRIM71 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree |