TissGeneSummary for TMEM207 |
Gene summary |
Basic gene information | Gene symbol | TMEM207 |
Gene name | transmembrane protein 207 | |
Synonyms | UNQ846 | |
Cytomap | UCSC genome browser: 3q28 | |
Type of gene | protein-coding | |
RefGenes | NM_207316.1, | |
Description | SRSR846 | |
Modification date | 20141207 | |
dbXrefs | MIM : 614786 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198398 | ||
HPRD : 15621 | ||
Vega : OTTHUMG00000156213 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TMEM207 | |
BioGPS: 131920 | ||
Pathway | NCI Pathway Interaction Database: TMEM207 | |
KEGG: TMEM207 | ||
REACTOME: TMEM207 | ||
Pathway Commons: TMEM207 | ||
Context | iHOP: TMEM207 | |
ligand binding site mutation search in PubMed: TMEM207 | ||
UCL Cancer Institute: TMEM207 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of TMEM207 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TMEM207 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -1.168877792 | 5.319606583 | -6.488484375 | 1.42E-19 | 8.16E-18 |
KICH | -2.007434917 | 5.293173083 | -7.300608 | 3.30E-14 | 5.20E-13 |
KIRC | -1.649690639 | 5.161784361 | -6.811475 | 6.07E-41 | 2.62E-39 |
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TissGene-miRNA for TMEM207 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TMEM207 |
TissGeneSNV for TMEM207 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P120H | LUAD | 1 |
p.A105S | UCEC | 1 |
p.P109R | COAD | 1 |
p.R81* | STAD | 1 |
p.Q25* | UCEC | 1 |
p.Q25X | SKCM | 1 |
p.L58M | UCEC | 1 |
p.L60F | HNSC | 1 |
p.Q118K | CESC | 1 |
p.L19V | LIHC | 1 |
p.Q25* | SKCM | 1 |
p.E140K | SKCM | 1 |
p.F7S | STAD | 1 |
p.G134A | LUAD | 1 |
p.S29* | LUSC | 1 |
p.G112R | GBM | 1 |
p.V70I | LUAD | 1 |
p.R81X | STAD | 1 |
p.L64V | BRCA | 1 |
p.R79S | STAD | 1 |
p.G134C | LUAD | 1 |
p.Q74X | SKCM | 1 |
p.F7L | BLCA | 1 |
p.V70A | LUAD | 1 |
p.Q74* | SKCM | 1 |
p.S135F | THYM | 1 |
p.A106S | LUAD | 1 |
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TissGeneCNV for TMEM207 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TMEM207 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE813282 | TMEM207-FMR1 | chr3:190154659 | chrX:147006630 | |
TCGAfusionPortal | PRADA | LUSC | TCGA-22-5491-01A | IL1RAP-TMEM207 | In-frame | Chr3:190326970 | Chr3:190165616 |
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TissGeneNet for TMEM207 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TMEM207 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TMEM207 |
TissGeneDrug for TMEM207 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TMEM207 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0206696 | Carcinoma, Signet Ring Cell | 2 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0334342 | Skin appendage adenoma | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |