TissGeneSummary for ADAD1 |
Gene summary |
Basic gene information | Gene symbol | ADAD1 |
Gene name | adenosine deaminase domain containing 1 (testis-specific) | |
Synonyms | Tenr | |
Cytomap | UCSC genome browser: 4q27 | |
Type of gene | protein-coding | |
RefGenes | NM_001159285.1, NM_001159295.1,NM_139243.3, | |
Description | adenosine deaminase domain-containing protein 1testis nuclear RNA-binding protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 614130 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164113 | ||
HPRD : 15594 | ||
Vega : OTTHUMG00000150128 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAD1 | |
BioGPS: 132612 | ||
Pathway | NCI Pathway Interaction Database: ADAD1 | |
KEGG: ADAD1 | ||
REACTOME: ADAD1 | ||
Pathway Commons: ADAD1 | ||
Context | iHOP: ADAD1 | |
ligand binding site mutation search in PubMed: ADAD1 | ||
UCL Cancer Institute: ADAD1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ADAD1 | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ADAD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ADAD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ADAD1 |
TissGeneSNV for ADAD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E393K | SKCM | 3 |
p.S11L | UCEC | 3 |
p.E85K | SKCM | 2 |
p.E354K | SKCM | 2 |
p.E524* | UCEC | 1 |
p.M465I | SKCM | 1 |
p.D264Y | LUAD | 1 |
p.T57M | UCEC | 1 |
p.L324H | CESC | 1 |
p.E85K | HNSC | 1 |
p.L24M | UCEC | 1 |
p.P63T | LIHC | 1 |
p.M88I | SKCM | 1 |
p.G419R | LGG | 1 |
p.P569S | SKCM | 1 |
p.V457A | STAD | 1 |
p.S258I | LUAD | 1 |
p.E184* | LUAD | 1 |
p.E62K | READ | 1 |
p.K22N | CESC | 1 |
p.Q558K | LUAD | 1 |
p.P452T | STAD | 1 |
p.E428K | UCEC | 1 |
p.G479V | STAD | 1 |
p.V213A | LUSC | 1 |
p.K539T | STAD | 1 |
p.T390S | LUSC | 1 |
p.V197A | HNSC | 1 |
p.C372F | ESCA | 1 |
p.V486L | LUAD | 1 |
p.M49I | SKCM | 1 |
p.E226G | CESC | 1 |
p.Y227N | COAD | 1 |
p.R171Q | SKCM | 1 |
p.Q546K | LUSC | 1 |
p.D375N | SKCM | 1 |
p.V53A | SKCM | 1 |
p.I322T | UCEC | 1 |
p.I212F | LUAD | 1 |
p.R278K | SKCM | 1 |
p.S422G | LUSC | 1 |
p.G491V | STAD | 1 |
p.S311F | LIHC | 1 |
p.L159F | UCEC | 1 |
p.V275A | READ | 1 |
p.S554F | SKCM | 1 |
p.E528K | SKCM | 1 |
p.P498L | SKCM | 1 |
p.S152C | KIRP | 1 |
p.S311C | BRCA | 1 |
p.C306Y | SARC | 1 |
p.F86C | UCEC | 1 |
p.R287K | STAD | 1 |
p.T424A | KIRP | 1 |
p.A532V | PAAD | 1 |
p.V370A | SKCM | 1 |
p.T32M | STAD | 1 |
p.R171Q | SARC | 1 |
p.P61S | SKCM | 1 |
p.G201E | SKCM | 1 |
p.P63L | STAD | 1 |
p.E169K | SKCM | 1 |
p.S47T | BLCA | 1 |
p.R278I | UCEC | 1 |
p.L69F | SKCM | 1 |
p.S346F | COAD | 1 |
p.D260N | STAD | 1 |
p.M465I | LUAD | 1 |
p.R224L | LUAD | 1 |
p.H536R | ESCA | 1 |
p.A29V | UCEC | 1 |
p.R517Q | ESCA | 1 |
p.S3R | LGG | 1 |
p.F237L | GBM | 1 |
p.N343T | LUAD | 1 |
p.R241K | CESC | 1 |
p.R451K | SKCM | 1 |
p.E226K | SKCM | 1 |
p.T494N | HNSC | 1 |
p.R425T | HNSC | 1 |
p.P61L | SARC | 1 |
p.L65I | OV | 1 |
p.D270N | STAD | 1 |
p.E531K | BLCA | 1 |
p.E42K | STAD | 1 |
p.Q573* | UCEC | 1 |
p.N519S | STAD | 1 |
p.Q407K | LUAD | 1 |
p.T120A | STAD | 1 |
p.S152P | UCEC | 1 |
p.R434C | HNSC | 1 |
p.I82K | STAD | 1 |
p.A430T | UCEC | 1 |
p.M88I | LUAD | 1 |
p.C550Y | UCEC | 1 |
p.N218I | SKCM | 1 |
p.S311Y | UCEC | 1 |
p.P97L | PAAD | 1 |
p.L289R | ESCA | 1 |
p.I565T | BLCA | 1 |
p.R224H | OV | 1 |
p.A207S | LUAD | 1 |
p.M326I | SKCM | 1 |
p.S71Y | THYM | 1 |
p.S11L | SKCM | 1 |
p.K214* | SKCM | 1 |
p.L69I | ESCA | 1 |
p.K492* | SKCM | 1 |
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TissGeneCNV for ADAD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ADAD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ADAD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ADAD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ADAD1 |
TissGeneDrug for ADAD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ADAD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree,GAD |
umls:C0007570 | Celiac Disease | 3 | GAD,LHGDN |
umls:C0009324 | Ulcerative Colitis | 3 | BeFree,GAD,GWASCAT |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 3 | GAD |
umls:C0010346 | Crohn Disease | 1 | GAD |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0020538 | Hypertensive disease | 1 | GAD |
umls:C0026769 | Multiple Sclerosis | 1 | BeFree,GAD |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |