TissGeneSummary for SPATA18 |
Gene summary |
Basic gene information | Gene symbol | SPATA18 |
Gene name | spermatogenesis associated 18 | |
Synonyms | Mieap|SPETEX1 | |
Cytomap | UCSC genome browser: 4q12 | |
Type of gene | protein-coding | |
RefGenes | NM_001297608.1, NM_145263.3,NR_123728.1, | |
Description | mitochondria-eating proteinspermatogenesis associated 18 homologspermatogenesis-associated protein 18 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612814 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163071 | ||
HPRD : 14050 | ||
Vega : OTTHUMG00000128698 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPATA18 | |
BioGPS: 132671 | ||
Pathway | NCI Pathway Interaction Database: SPATA18 | |
KEGG: SPATA18 | ||
REACTOME: SPATA18 | ||
Pathway Commons: SPATA18 | ||
Context | iHOP: SPATA18 | |
ligand binding site mutation search in PubMed: SPATA18 | ||
UCL Cancer Institute: SPATA18 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SPATA18 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006974 | cellular response to DNA damage stimulus | 21264221 | GO:0006974 | cellular response to DNA damage stimulus | 21264221 |
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TissGeneExp for SPATA18 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.506400545 | 0.630099156 | 1.876301389 | 5.85E-26 | 7.67E-25 |
LIHC | -1.382787678 | 0.318226322 | -1.701014 | 1.38E-06 | 7.21E-06 |
PRAD | -0.439256293 | 0.817787938 | -1.257044231 | 2.01E-10 | 3.99E-09 |
THCA | -0.196806423 | -1.72567083 | 1.528864407 | 7.77E-09 | 3.94E-08 |
BRCA | -0.080985713 | 1.254597621 | -1.335583333 | 6.67E-16 | 3.69E-15 |
LUAD | -0.309675126 | 1.470366253 | -1.780041379 | 4.24E-08 | 1.75E-07 |
LUSC | -0.860996188 | 1.570092048 | -2.431088235 | 3.00E-14 | 1.65E-13 |
HNSC | -0.971644934 | 0.81416902 | -1.785813953 | 6.87E-10 | 1.15E-08 |
BLCA | -1.33194273 | -0.112837467 | -1.219105263 | 0.00553 | 0.02840351 |
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TissGene-miRNA for SPATA18 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPATA18 |
TissGeneSNV for SPATA18 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G442E | SKCM | 2 |
p.S496L | SKCM | 2 |
p.S360L | SKCM | 2 |
p.D69N | SKCM | 2 |
p.R77H | PRAD | 1 |
p.Q216H | BLCA | 1 |
p.S294F | SKCM | 1 |
p.S101F | LGG | 1 |
p.R455C | UCEC | 1 |
p.R502H | UCEC | 1 |
p.A429E | DLBC | 1 |
p.R504Q | UCEC | 1 |
p.R285K | LUAD | 1 |
p.S364F | SKCM | 1 |
p.Q35R | ESCA | 1 |
p.W81L | LUSC | 1 |
p.Q134P | LUAD | 1 |
p.E422D | BLCA | 1 |
p.K483N | UCEC | 1 |
p.S159F | SKCM | 1 |
p.R514H | ESCA | 1 |
p.F371V | STAD | 1 |
p.R290L | HNSC | 1 |
p.D478N | SKCM | 1 |
p.P403S | SKCM | 1 |
p.P100T | LUAD | 1 |
p.A349E | LUAD | 1 |
p.S257C | LUAD | 1 |
p.D107N | LUAD | 1 |
p.R265C | BLCA | 1 |
p.R206Q | SKCM | 1 |
p.V71L | LUAD | 1 |
p.E341_splice | LUSC | 1 |
p.P260S | SKCM | 1 |
p.P409L | SKCM | 1 |
p.R298S | LUAD | 1 |
p.V410A | PAAD | 1 |
p.N136S | LIHC | 1 |
p.A157T | LUSC | 1 |
p.V379F | LUAD | 1 |
p.Q389K | STAD | 1 |
p.E446K | STAD | 1 |
p.R197L | LIHC | 1 |
p.D228Y | LUAD | 1 |
p.K359I | LUAD | 1 |
p.T32M | UCEC | 1 |
p.R119W | SKCM | 1 |
p.R333W | UCEC | 1 |
p.K404N | LUAD | 1 |
p.S257N | LUSC | 1 |
p.I396L | STAD | 1 |
p.F350L | ACC | 1 |
p.I355T | KIRC | 1 |
p.K404N | CHOL | 1 |
p.T13S | HNSC | 1 |
p.D69V | STAD | 1 |
p.R290H | UCEC | 1 |
p.R490* | LUAD | 1 |
p.E204Q | OV | 1 |
p.R7K | LUAD | 1 |
p.N31S | LUAD | 1 |
p.S291C | BLCA | 1 |
p.V411I | UCEC | 1 |
p.S97N | LGG | 1 |
p.E238K | READ | 1 |
p.R502C | SKCM | 1 |
p.R234Q | COAD | 1 |
p.V340L | LUAD | 1 |
p.R184H | STAD | 1 |
p.E246D | DLBC | 1 |
p.L302F | HNSC | 1 |
p.P260L | SKCM | 1 |
p.D326N | UCEC | 1 |
p.P408L | BLCA | 1 |
p.S417G | LUAD | 1 |
p.S515N | STAD | 1 |
p.Y310N | LUAD | 1 |
p.R284W | LIHC | 1 |
p.G56R | SKCM | 1 |
p.A317V | STAD | 1 |
p.P262L | SKCM | 1 |
p.P408S | SKCM | 1 |
p.R333Q | STAD | 1 |
p.P286Q | STAD | 1 |
p.H356Y | SKCM | 1 |
p.L383I | UCEC | 1 |
p.S459* | LUSC | 1 |
p.S388Y | UCEC | 1 |
p.R526W | PRAD | 1 |
p.R524Q | SKCM | 1 |
p.S406L | SKCM | 1 |
p.S85F | SKCM | 1 |
p.G518A | LGG | 1 |
p.L79* | SKCM | 1 |
p.S360* | LUAD | 1 |
p.R524Q | PRAD | 1 |
p.R305W | SKCM | 1 |
p.R454C | UCS | 1 |
p.V331I | TGCT | 1 |
p.S364T | PRAD | 1 |
p.Q51R | UCEC | 1 |
p.K404N | UCEC | 1 |
p.R273T | LUAD | 1 |
p.G92R | PRAD | 1 |
p.P114T | UCEC | 1 |
p.R234Q | UCEC | 1 |
p.A473T | STAD | 1 |
p.R67S | LUAD | 1 |
p.A297V | LUAD | 1 |
p.D326Y | LUAD | 1 |
p.R67C | COAD | 1 |
p.S501I | BRCA | 1 |
p.R526Q | PAAD | 1 |
p.Q139E | LUSC | 1 |
p.L236M | HNSC | 1 |
p.K404N | PAAD | 1 |
p.Q431H | BRCA | 1 |
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TissGeneCNV for SPATA18 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPATA18 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-86-8074-01A | CYTH3-SPATA18 | In-frame | Chr7:6217454 | Chr4:52938083 |
TCGAfusionPortal | PRADA | LUSC | TCGA-22-4591-01A | SPATA18-EXOC1 | In-frame | Chr4:52917957 | Chr4:56768510 |
TCGAfusionPortal | PRADA | LUSC | TCGA-66-2787-01A | SGCB-SPATA18 | In-frame | Chr4:52899597 | Chr4:52926585 |
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TissGeneNet for SPATA18 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPATA18 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPATA18 |
TissGeneDrug for SPATA18 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPATA18 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0686353 | Muscular Dystrophies, Limb-Girdle | 1 | LHGDN |