TissGeneSummary for DPCR1 |
Gene summary |
Basic gene information | Gene symbol | DPCR1 |
Gene name | diffuse panbronchiolitis critical region 1 | |
Synonyms | PBLT | |
Cytomap | UCSC genome browser: 6p21.33 | |
Type of gene | protein-coding | |
RefGenes | NM_080870.3, | |
Description | diffuse panbronchiolitis critical region protein 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 613928 | |
HGNC : HGNC | ||
Ensembl : ENSG00000168631 | ||
HPRD : 16073 | ||
Vega : OTTHUMG00000031104 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DPCR1 | |
BioGPS: 135656 | ||
Pathway | NCI Pathway Interaction Database: DPCR1 | |
KEGG: DPCR1 | ||
REACTOME: DPCR1 | ||
Pathway Commons: DPCR1 | ||
Context | iHOP: DPCR1 | |
ligand binding site mutation search in PubMed: DPCR1 | ||
UCL Cancer Institute: DPCR1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasStomach | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADSTAD | |
Reference showing the relevant tissue of DPCR1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DPCR1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.917042318 | 4.479320427 | -5.396362745 | 3.10E-25 | 7.05E-24 |
KICH | -2.961706475 | -1.280606475 | -1.6811 | 5.04E-13 | 6.31E-12 |
KIRP | -0.18199385 | -1.486690725 | 1.304696875 | 1.36E-05 | 5.50E-05 |
LUAD | 2.136653456 | 4.434296559 | -2.297643103 | 4.18E-07 | 1.47E-06 |
HNSC | -2.602027498 | 0.782807385 | -3.384834884 | 5.97E-10 | 1.03E-08 |
LIHC | -2.240682475 | -0.998368475 | -1.242314 | 0.022 | 0.042341421 |
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TissGene-miRNA for DPCR1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DPCR1 |
TissGeneSNV for DPCR1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G384R | KIRC | 6 |
p.H364N | KIRC | 4 |
p.P735Q | THYM | 3 |
p.K551N | KIRC | 2 |
p.R445G | KIRC | 2 |
p.P855Q | KIRC | 1 |
p.A849S | LIHC | 1 |
p.Q1358E | LUAD | 1 |
p.K1186T | DLBC | 1 |
p.E75D | UCEC | 1 |
p.A830T | LIHC | 1 |
p.I1287M | UVM | 1 |
p.F357S | LIHC | 1 |
p.T1197I | SKCM | 1 |
p.P735S | KIRC | 1 |
p.E1168K | SKCM | 1 |
p.P1244H | STAD | 1 |
p.P1208R | KIRP | 1 |
p.T1288P | SKCM | 1 |
p.E432K | ACC | 1 |
p.E470K | ESCA | 1 |
p.K1033N | SARC | 1 |
p.E1109X | READ | 1 |
p.A2T | ESCA | 1 |
p.E659K | CESC | 1 |
p.E1295D | BLCA | 1 |
p.E742X | READ | 1 |
p.P735Q | UCEC | 1 |
p.P380L | BRCA | 1 |
p.D1364N | SKCM | 1 |
p.A649V | LIHC | 1 |
p.G640E | KIRC | 1 |
p.R565G | KIRP | 1 |
p.N751K | KIRP | 1 |
p.E720G | PRAD | 1 |
p.S1253C | UVM | 1 |
p.E558Q | KIRC | 1 |
p.P535L | KIRC | 1 |
p.G212S | CESC | 1 |
p.T105S | BRCA | 1 |
p.D1367N | SKCM | 1 |
p.L716P | LIHC | 1 |
p.T1174M | GBM | 1 |
p.P380H | UCEC | 1 |
p.E720G | UCEC | 1 |
p.E20* | UCEC | 1 |
p.P535L | KICH | 1 |
p.E878D | COAD | 1 |
p.P460S | ESCA | 1 |
p.T967M | BRCA | 1 |
p.T853A | BRCA | 1 |
p.S1391P | SKCM | 1 |
p.P687T | LIHC | 1 |
p.G1293* | UCEC | 1 |
p.E606* | UCEC | 1 |
p.P301S | LIHC | 1 |
p.P1321S | SKCM | 1 |
p.R135Q | COAD | 1 |
p.A336T | UCEC | 1 |
p.P735Q | ESCA | 1 |
p.S415* | CESC | 1 |
p.P1321S | LIHC | 1 |
p.E1067* | UCEC | 1 |
p.E123V | KIRC | 1 |
p.S420C | CESC | 1 |
p.K238N | SARC | 1 |
p.S122Y | UCEC | 1 |
p.E79* | UCEC | 1 |
p.P1184L | KIRC | 1 |
p.E992A | UCEC | 1 |
p.T454I | CESC | 1 |
p.E1067K | COAD | 1 |
p.R85H | UCEC | 1 |
p.Q36K | COAD | 1 |
p.R445T | ESCA | 1 |
p.T823K | STAD | 1 |
p.L282V | CESC | 1 |
p.E510G | LIHC | 1 |
p.D1130N | SKCM | 1 |
p.E1124D | LIHC | 1 |
p.E1067K | UCEC | 1 |
p.S847R | KIRC | 1 |
p.L261F | UCEC | 1 |
p.C1196W | UVM | 1 |
p.P1298L | SKCM | 1 |
p.R138C | COAD | 1 |
p.N433K | COAD | 1 |
p.H1156R | ESCA | 1 |
p.R91C | CESC | 1 |
p.A397S | UCEC | 1 |
p.T159M | COAD | 1 |
p.E48* | UCEC | 1 |
p.R1354H | STAD | 1 |
p.P1390S | SKCM | 1 |
p.I324T | SKCM | 1 |
p.E72D | UCEC | 1 |
p.T201N | LIHC | 1 |
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TissGeneCNV for DPCR1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DPCR1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AI674906 | DPCR1-DPCR1 | chr6:2214391 | chr6:2212815 |
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TissGeneNet for DPCR1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DPCR1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DPCR1 |
TissGeneDrug for DPCR1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DPCR1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0024141 | Lupus Erythematosus, Systemic | 2 | GAD |
umls:C0878555 | Diffuse panbronchiolitis | 2 | BeFree,CTD_human,ORPHANET |
umls:C0004943 | Behcet Syndrome | 1 | GAD |
umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
umls:C0086445 | Idiopathic Membranous Glomerulonephritis | 1 | GWASCAT |
umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |