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| TissGeneSummary for CPA3 |
 Gene summary |
| Basic gene information | Gene symbol | CPA3 |
| Gene name | carboxypeptidase A3 (mast cell) | |
| Synonyms | MC-CPA | |
| Cytomap | UCSC genome browser: 3q24 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001870.2, | |
| Description | mast cell carboxypeptidase Atissue carboxypeptidase A | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 114851 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000163751 | ||
| HPRD : 00270 | ||
| Vega : OTTHUMG00000159526 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CPA3 | |
| BioGPS: 1359 | ||
| Pathway | NCI Pathway Interaction Database: CPA3 | |
| KEGG: CPA3 | ||
| REACTOME: CPA3 | ||
| Pathway Commons: CPA3 | ||
| Context | iHOP: CPA3 | |
| ligand binding site mutation search in PubMed: CPA3 | ||
| UCL Cancer Institute: CPA3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLLUAD,LUSC | |
| Reference showing the relevant tissue of CPA3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CPA3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 0.883106563 | 2.425602717 | -1.542496154 | 2.36E-05 | 9.85E-05 |
| KIRC | 0.791760516 | -1.587710317 | 2.379470833 | 2.82E-10 | 9.58E-10 |
| LUAD | 1.841646484 | 3.964930966 | -2.123284483 | 5.21E-11 | 3.23E-10 |
| LUSC | 1.129458147 | 4.189707167 | -3.06024902 | 3.78E-16 | 2.72E-15 |
| STAD | 1.289044544 | 2.478419544 | -1.189375 | 0.00708 | 0.025807002 |
| THCA | -3.070781833 | -4.206408952 | 1.135627119 | 0.00108 | 0.00249595 |
| BLCA | -0.195018943 | 2.557349478 | -2.752368421 | 5.21E-05 | 0.000662117 |
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| TissGene-miRNA for CPA3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CPA3 |
| TissGeneSNV for CPA3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R237C | SKCM | 3 |
| p.E34K | SKCM | 3 |
| p.P153S | SKCM | 2 |
| p.G160W | LUAD | 1 |
| p.H324Y | LUAD | 1 |
| p.P313L | SKCM | 1 |
| p.F375I | HNSC | 1 |
| p.K86E | SKCM | 1 |
| p.D368N | BLCA | 1 |
| p.S392C | SKCM | 1 |
| p.R209Q | HNSC | 1 |
| p.A285D | STAD | 1 |
| p.R393W | SKCM | 1 |
| p.R28H | BLCA | 1 |
| p.D266N | BLCA | 1 |
| p.R209* | PAAD | 1 |
| p.P277T | COAD | 1 |
| p.D50H | LUAD | 1 |
| p.L43F | ESCA | 1 |
| p.R142C | SKCM | 1 |
| p.I93S | LUAD | 1 |
| p.T148N | BLCA | 1 |
| p.E391X | STAD | 1 |
| p.S115R | HNSC | 1 |
| p.L9F | HNSC | 1 |
| p.D95Y | CESC | 1 |
| p.I301T | PRAD | 1 |
| p.Q84K | LUSC | 1 |
| p.G383D | SKCM | 1 |
| p.F218S | LIHC | 1 |
| p.R341G | ESCA | 1 |
| p.F254V | UCEC | 1 |
| p.A276E | LUSC | 1 |
| p.L14F | BLCA | 1 |
| p.G247R | LUAD | 1 |
| p.D105H | BLCA | 1 |
| p.R28C | UCEC | 1 |
| p.E400K | SKCM | 1 |
| p.L327F | THCA | 1 |
| p.K195N | LIHC | 1 |
| p.R209X | PAAD | 1 |
| p.E99K | SKCM | 1 |
| p.E352K | SKCM | 1 |
| p.T194A | SKCM | 1 |
| p.N219D | COAD | 1 |
| p.S71N | LUAD | 1 |
| p.P262S | SKCM | 1 |
| p.F254C | UCEC | 1 |
| p.S392F | SKCM | 1 |
| p.I371F | LUAD | 1 |
| p.P322R | COAD | 1 |
| p.V60L | ACC | 1 |
| p.F407C | UCEC | 1 |
| p.S359L | SKCM | 1 |
| p.S307F | SKCM | 1 |
| p.S75F | UCEC | 1 |
| p.T148N | LUAD | 1 |
| p.E296K | SKCM | 1 |
| p.M402I | OV | 1 |
| p.D95N | SKCM | 1 |
| p.G383S | SKCM | 1 |
| p.Y155H | BLCA | 1 |
| p.N63D | UCEC | 1 |
| p.E130Q | CESC | 1 |
| p.G383V | LUSC | 1 |
| p.L3I | LUAD | 1 |
| p.E130K | SKCM | 1 |
| p.R399K | HNSC | 1 |
| p.D109N | HNSC | 1 |
| p.L43F | LUSC | 1 |
| p.W365X | SKCM | 1 |
| p.R380L | LUSC | 1 |
| p.M139I | LUAD | 1 |
| p.S305F | SKCM | 1 |
| p.W365* | SKCM | 1 |
| p.G222R | HNSC | 1 |
| p.E296K | LUAD | 1 |
| p.W52R | LUAD | 1 |
| p.E161K | SKCM | 1 |
| p.D83N | SKCM | 1 |
| p.H176Q | LUAD | 1 |
| p.A177T | STAD | 1 |
| p.L9V | UCS | 1 |
| p.R178Q | LUAD | 1 |
| p.H114Y | LUAD | 1 |
| p.S417F | SKCM | 1 |
| p.V190A | COAD | 1 |
| p.P216L | SKCM | 1 |
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| TissGeneCNV for CPA3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CPA3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | LUSC | TCGA-22-5474-01A | TFRC-CPA3 | Out-of-Frame | chr3:195787050 | chr3:148614306 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-22-5474-01A | TFRC-CPA3 | Out-of-frame | Chr3:195787051 | Chr3:148614307 |
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| TissGeneNet for CPA3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CPA3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CPA3 |
| TissGeneDrug for CPA3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CPA3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0004096 | Asthma | 3 | BeFree |
| umls:C0341106 | Eosinophilic esophagitis | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
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