TissGeneSummary for TMEM139 |
Gene summary |
Basic gene information | Gene symbol | TMEM139 |
Gene name | transmembrane protein 139 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 7q34 | |
Type of gene | protein-coding | |
RefGenes | NM_001242773.2, NM_001242774.2,NM_001242775.2,NM_001282876.1,NM_001282877.1, NM_153345.3,NR_040003.2,NR_104250.1,NR_104251.1, NR_104252.1,NR_104253.1,NR_104254.1, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000178826 | ||
HPRD : 08298 | ||
Vega : OTTHUMG00000152652 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TMEM139 | |
BioGPS: 135932 | ||
Pathway | NCI Pathway Interaction Database: TMEM139 | |
KEGG: TMEM139 | ||
REACTOME: TMEM139 | ||
Pathway Commons: TMEM139 | ||
Context | iHOP: TMEM139 | |
ligand binding site mutation search in PubMed: TMEM139 | ||
UCL Cancer Institute: TMEM139 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of TMEM139 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TMEM139 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -0.426166143 | 1.122031225 | -1.548197368 | 1.79E-09 | 6.28E-09 |
LUSC | -2.417707423 | 1.866808263 | -4.284515686 | 2.54E-19 | 2.72E-18 |
LUAD | -0.580962392 | 2.107180711 | -2.688143103 | 2.06E-17 | 2.67E-16 |
PRAD | -2.825740907 | -1.363138984 | -1.462601923 | 1.73E-09 | 2.53E-08 |
KICH | 0.590883401 | 3.492151401 | -2.901268 | 1.21E-14 | 2.22E-13 |
THCA | -0.933053684 | 2.080286994 | -3.013340678 | 8.81E-16 | 1.34E-14 |
STAD | 1.413607651 | -0.403911099 | 1.81751875 | 0.00108 | 0.005648651 |
LIHC | 0.231901401 | 1.362435401 | -1.130534 | 0.0015 | 0.003966071 |
HNSC | -3.808688134 | -2.022450925 | -1.786237209 | 4.89E-05 | 0.000237635 |
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TissGene-miRNA for TMEM139 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TMEM139 |
TissGeneSNV for TMEM139 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R136K | COAD | 1 |
p.P113L | PRAD | 1 |
p.V38F | THYM | 1 |
p.P193S | SKCM | 1 |
p.P37L | SKCM | 1 |
p.F58S | KIRP | 1 |
p.S12N | COAD | 1 |
p.R57W | SKCM | 1 |
p.Y114H | KIRP | 1 |
p.V96M | STAD | 1 |
p.G79S | LUAD | 1 |
p.H201Y | BLCA | 1 |
p.A137T | OV | 1 |
p.L10M | LUSC | 1 |
p.R158I | BLCA | 1 |
p.P75Q | SKCM | 1 |
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TissGeneCNV for TMEM139 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TMEM139 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TMEM139 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TMEM139 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TMEM139 |
TissGeneDrug for TMEM139 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TMEM139 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027626 | Neoplasm Invasiveness | 1 | CTD_human |