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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CPN1
check button Gene summary
Basic gene informationGene symbolCPN1
Gene namecarboxypeptidase N, polypeptide 1
SynonymsCPN|SCPN
CytomapUCSC genome browser: 10q24.2
Type of geneprotein-coding
RefGenesNM_001308.2,
Descriptionanaphylatoxin inactivatorarginine carboxypeptidasecarboxypeptidase Kcarboxypeptidase N catalytic chaincarboxypeptidase N catalytic subunitcarboxypeptidase N polypeptide 1 50 kDcarboxypeptidase N small subunitkininase Ikininase-1lysine carboxypept
Modification date20141207
dbXrefs MIM : 603103
HGNC : HGNC
Ensembl : ENSG00000120054
HPRD : 09120
Vega : OTTHUMG00000018896
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CPN1
BioGPS: 1369
PathwayNCI Pathway Interaction Database: CPN1
KEGG: CPN1
REACTOME: CPN1
Pathway Commons: CPN1
ContextiHOP: CPN1
ligand binding site mutation search in PubMed: CPN1
UCL Cancer Institute: CPN1
Assigned class in TissGDB*B
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCSKCM
Reference showing the relevant tissue of CPN1
Description by TissGene annotationsHave significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for CPN1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-1.892470737-0.010902737-1.8815689.77E-106.10E-09
LIHC7.5424072639.288607263-1.74621.19E-054.94E-05
STAD-0.605051362-1.9118732371.3068218750.004850.018806293
COAD0.095135416-1.172287661.2674230770.001420.003938253


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TissGene-miRNA for CPN1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
ACChsa-miR-330-5pMIMAT00046930.0053-0.3278
ACChsa-miR-330-5pMIMAT00046930.0053-0.3278


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TissGeneMut for CPN1
TissGeneSNV for CPN1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E41KSKCM3
p.E447KLIHC2
p.E336KHNSC1
p.P457HLUSC1
p.A330SUCEC1
p.W189*SKCM1
p.V115IOV1
p.V55MCOAD1
p.E101KSKCM1
p.R322QHNSC1
p.E89KSTAD1
p.L380PESCA1
p.R238CSTAD1
p.L211IUCEC1
p.E174KSKCM1
p.R322WLGG1
p.S50RSTAD1
p.A138VPRAD1
p.A222VCOAD1
p.R235*LIHC1
p.D372ACOAD1
p.S128FLUSC1
p.V115ISTAD1
p.T34SLUAD1
p.D132ELUAD1
p.T245MSTAD1
p.R27HLGG1
p.E89KUCEC1
p.L9PACC1
p.H124DCESC1
p.E196*LUAD1
p.M292LUCS1
p.T402IDLBC1
p.E449KSKCM1
p.F314LSKCM1
p.E194KSTAD1
p.S212LBLCA1
p.E397QCESC1
p.S100LLUSC1
p.S360YREAD1
p.L307MLUSC1
p.G344ESKCM1
p.P396LHNSC1
p.E304QBLCA1
p.T121MLUAD1
p.V403MLUAD1
p.R93HESCA1
p.G133SPRAD1
p.A261VUCEC1
p.T168ISKCM1
p.R53CSTAD1
p.I279TBRCA1
p.A199VPRAD1
p.E407DBLCA1
p.H366DLUAD1
p.G92RCOAD1
p.R235XLIHC1
p.R27HSTAD1
p.A389SLUAD1
p.R322LSKCM1
p.E41KLGG1
p.P315LSKCM1
p.G434RSKCM1
p.G341DUCEC1
p.A19SHNSC1
p.W285CLUAD1
p.D395NBRCA1
p.R33QSKCM1
p.E329KSKCM1
p.K313*LUAD1
p.R198LLUAD1
p.K438TSTAD1
p.D132NREAD1
p.K144TREAD1
p.A139VBRCA1
p.W189XSKCM1
p.E447QCESC1
p.E41QBLCA1
p.N301SUCEC1
p.G272RDLBC1
p.S100LUCEC1
p.N208SLUSC1
p.N162SSKCM1
p.A90VPAAD1
p.V157LLUAD1
p.Q252RBLCA1
p.R328LLUAD1
p.R239CSTAD1


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TissGeneCNV for CPN1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CPN1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for CPN1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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COAD (tumor)COAD (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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HNSC (tumor)HNSC (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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KICH (tumor)KICH (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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KIRC (tumor)KIRC (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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KIRP (tumor)KIRP (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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LIHC (tumor)LIHC (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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LUAD (tumor)LUAD (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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LUSC (tumor)LUSC (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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PRAD (tumor)PRAD (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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STAD (tumor)STAD (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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THCA (tumor)THCA (normal)
CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (tumor)CPN1, CDC42, KNG1, C5, CLEC4G, C3, CPN2 (normal)
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TissGeneProg for CPN1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CPN1
TissGeneDrug for CPN1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CPN1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0002395Alzheimer's Disease1BeFree
umls:C0003864Arthritis1BeFree
umls:C0007112Adenocarcinoma of prostate1BeFree
umls:C0010200Coughing1BeFree
umls:C0015695Fatty Liver1GAD
umls:C0018772Hearing Loss, Partial1GWASCAT
umls:C0398782Carboxypeptidase N Deficiency1CLINVAR,CTD_human,UNIPROT
umls:C0524620Metabolic Syndrome X1GAD
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C1384666hearing impairment1GWASCAT
umls:C1561546Alkaline Phosphatase Adverse Event1GAD