TissGeneSummary for ASZ1 |
Gene summary |
Basic gene information | Gene symbol | ASZ1 |
Gene name | ankyrin repeat, SAM and basic leucine zipper domain containing 1 | |
Synonyms | ALP1|ANKL1|C7orf7|CT1.19|GASZ|Orf3 | |
Cytomap | UCSC genome browser: 7q31.2 | |
Type of gene | protein-coding | |
RefGenes | NR_023315.1, NM_001301821.1,NM_001301822.1,NM_130768.2, | |
Description | ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1ankyrin-like 1ankyrin-like protein 1germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 605797 | |
HGNC : HGNC | ||
Ensembl : ENSG00000154438 | ||
HPRD : 10677 | ||
Vega : OTTHUMG00000064565 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ASZ1 | |
BioGPS: 136991 | ||
Pathway | NCI Pathway Interaction Database: ASZ1 | |
KEGG: ASZ1 | ||
REACTOME: ASZ1 | ||
Pathway Commons: ASZ1 | ||
Context | iHOP: ASZ1 | |
ligand binding site mutation search in PubMed: ASZ1 | ||
UCL Cancer Institute: ASZ1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ASZ1 | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ASZ1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ASZ1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ASZ1 |
TissGeneSNV for ASZ1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E21K | SKCM | 2 |
p.R7Q | HNSC | 2 |
p.M217T | GBM | 1 |
p.W25* | SKCM | 1 |
p.A5G | STAD | 1 |
p.T274R | BRCA | 1 |
p.A105E | ESCA | 1 |
p.G79E | SKCM | 1 |
p.L330F | SKCM | 1 |
p.G172E | BLCA | 1 |
p.Q112H | SKCM | 1 |
p.P240L | SKCM | 1 |
p.L168F | SKCM | 1 |
p.E16K | UCS | 1 |
p.R148K | LUAD | 1 |
p.P395L | SKCM | 1 |
p.I458M | HNSC | 1 |
p.E48X | READ | 1 |
p.L305V | BRCA | 1 |
p.E16K | SKCM | 1 |
p.H122Y | SKCM | 1 |
p.H228D | LUAD | 1 |
p.G205R | LUAD | 1 |
p.D411Y | HNSC | 1 |
p.K325I | SKCM | 1 |
p.L330P | SKCM | 1 |
p.T33M | SKCM | 1 |
p.E431V | HNSC | 1 |
p.I450L | UCEC | 1 |
p.A86V | UCEC | 1 |
p.K46N | UCEC | 1 |
p.E431K | SKCM | 1 |
p.Q424* | SKCM | 1 |
p.G462S | SKCM | 1 |
p.D293G | UCEC | 1 |
p.T33M | LGG | 1 |
p.E312* | UCEC | 1 |
p.T307N | LUAD | 1 |
p.D31N | COAD | 1 |
p.Q424X | SKCM | 1 |
p.D299V | MESO | 1 |
p.A2V | STAD | 1 |
p.G462S | LGG | 1 |
p.E21K | LUAD | 1 |
p.Q247H | UCEC | 1 |
p.W80R | ACC | 1 |
p.Q63K | BRCA | 1 |
p.I378T | PAAD | 1 |
p.K49Q | STAD | 1 |
p.A222S | HNSC | 1 |
p.G460R | LIHC | 1 |
p.E16K | LUAD | 1 |
p.K418E | LUAD | 1 |
p.D411N | UCEC | 1 |
p.R7* | STAD | 1 |
p.A2V | GBM | 1 |
p.A92V | BLCA | 1 |
p.S60L | SKCM | 1 |
p.H161R | PCPG | 1 |
p.M308I | SKCM | 1 |
p.R32Q | SKCM | 1 |
p.S120F | SKCM | 1 |
p.V198L | GBM | 1 |
p.D267Y | READ | 1 |
p.Y155H | KIRC | 1 |
p.R298T | OV | 1 |
p.H268Y | SKCM | 1 |
p.G79R | SKCM | 1 |
p.L258M | HNSC | 1 |
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TissGeneCNV for ASZ1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ASZ1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AC-A2QH-01A | AFF3-ASZ1 | In-frame | Chr2:100453939 | Chr7:117066989 |
TCGAfusionPortal | PRADA | LUAD | TCGA-86-8672-01A | ST7OT4-ASZ1 | Out-of-frame | Chr7:116595207 | Chr7:117025863 |
TCGAfusionPortal | PRADA | LUAD | TCGA-86-8672-01A | ST7-ASZ1 | Out-of-frame | Chr7:116593745 | Chr7:117025863 |
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TissGeneNet for ASZ1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ASZ1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ASZ1 |
TissGeneDrug for ASZ1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ASZ1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0085293 | Hepatitis E | 10 | BeFree |
umls:C0001314 | Acute Disease | 1 | BeFree |
umls:C0007222 | Cardiovascular Diseases | 1 | GAD |
umls:C0010068 | Coronary heart disease | 1 | GWASCAT |
umls:C0013371 | Shigella Infections | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | CTD_human |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0085110 | Severe Combined Immunodeficiency | 1 | BeFree |
umls:C0302809 | Fulminant hepatitis | 1 | BeFree |
umls:C1956346 | Coronary Artery Disease | 1 | GAD |
umls:C3825568 | Tumors in animals | 1 | BeFree |