TissGeneSummary for FAM92A1 |
Gene summary |
Basic gene information | Gene symbol | FAM92A1 |
Gene name | family with sequence similarity 92, member A1 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 8q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001283034.1, NM_145269.4,NR_104267.1,NR_104268.1, | |
Description | protein FAM92A1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
HPRD : 14061 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM92A1 | |
BioGPS: 137392 | ||
Pathway | NCI Pathway Interaction Database: FAM92A1 | |
KEGG: FAM92A1 | ||
REACTOME: FAM92A1 | ||
Pathway Commons: FAM92A1 | ||
Context | iHOP: FAM92A1 | |
ligand binding site mutation search in PubMed: FAM92A1 | ||
UCL Cancer Institute: FAM92A1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM92A1 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM92A1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
PRAD | -1.830023529 | -0.514140836 | -1.315882692 | 4.83E-14 | 4.01E-12 |
COAD | 0.043068779 | -1.355685067 | 1.398753846 | 3.28E-07 | 2.06E-06 |
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TissGene-miRNA for FAM92A1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM92A1 |
TissGeneSNV for FAM92A1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R141Q | STAD | 1 |
p.F287L | BLCA | 1 |
p.R264Q | UCS | 1 |
p.V20F | HNSC | 1 |
p.A42V | STAD | 1 |
p.F34L | LGG | 1 |
p.S241* | ESCA | 1 |
p.T18I | STAD | 1 |
p.E272K | HNSC | 1 |
p.E167K | SKCM | 1 |
p.C253F | BRCA | 1 |
p.R153T | LUAD | 1 |
p.E76Q | BLCA | 1 |
p.R233C | STAD | 1 |
p.A57V | STAD | 1 |
p.R163C | UCEC | 1 |
p.R84* | PAAD | 1 |
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TissGeneCNV for FAM92A1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM92A1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG996511 | FAM92A1-FAM92A1 | chr8:94729510 | chr8:94729523 | |
Chimerdb3.0 | ChiTaRs | NA | BE891031 | FAM92A1-CPSF2 | chr8:94731719 | chr14:92629517 | |
Chimerdb3.0 | ChiTaRs | NA | BU743023 | NID1-FAM92A1 | chr1:236197498 | chr8:94720761 |
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TissGeneNet for FAM92A1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM92A1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM92A1 |
TissGeneDrug for FAM92A1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM92A1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0022665 | Kidney Neoplasm | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |
umls:C1378703 | Renal carcinoma | 1 | BeFree |