TissGeneSummary for TAF1L |
Gene summary |
Basic gene information | Gene symbol | TAF1L |
Gene name | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | |
Synonyms | TAF2A2 | |
Cytomap | UCSC genome browser: 9p21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_153809.2, | |
Description | TAF(II)210TBP-associated factor 1-likeTBP-associated factor 210 kDaTBP-associated factor RNA polymerase 1-liketranscription initiation factor TFIID 210 kDa subunittranscription initiation factor TFIID subunit 1-like | |
Modification date | 20141207 | |
dbXrefs | MIM : 607798 | |
HGNC : HGNC | ||
Ensembl : ENSG00000122728 | ||
HPRD : 09696 | ||
Vega : OTTHUMG00000019747 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TAF1L | |
BioGPS: 138474 | ||
Pathway | NCI Pathway Interaction Database: TAF1L | |
KEGG: TAF1L | ||
REACTOME: TAF1L | ||
Pathway Commons: TAF1L | ||
Context | iHOP: TAF1L | |
ligand binding site mutation search in PubMed: TAF1L | ||
UCL Cancer Institute: TAF1L | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TAF1L | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006357 | regulation of transcription from RNA polymerase II promoter | 12217962 | GO:0045893 | positive regulation of transcription, DNA-templated | 12217962 | GO:0006357 | regulation of transcription from RNA polymerase II promoter | 12217962 | GO:0045893 | positive regulation of transcription, DNA-templated | 12217962 |
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TissGeneExp for TAF1L |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TAF1L |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TAF1L |
TissGeneSNV for TAF1L |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R888C | SKCM | 5 |
p.R1205Q | SKCM | 4 |
p.R1397C | HNSC | 2 |
p.P1365S | SKCM | 2 |
p.P1557S | SKCM | 2 |
p.E1819K | SKCM | 2 |
p.R558Q | UCEC | 2 |
p.R1200C | SKCM | 2 |
p.D414N | SKCM | 2 |
p.K1580N | LUSC | 1 |
p.R817W | SKCM | 1 |
p.G598C | LUAD | 1 |
p.R1584L | SKCM | 1 |
p.A217T | STAD | 1 |
p.R1252Q | UCEC | 1 |
p.L231S | BRCA | 1 |
p.R793W | SKCM | 1 |
p.Q171H | ESCA | 1 |
p.L865I | HNSC | 1 |
p.D1497N | CESC | 1 |
p.V1718L | UCEC | 1 |
p.D522H | HNSC | 1 |
p.R1165K | SKCM | 1 |
p.Y1626N | STAD | 1 |
p.R260C | COAD | 1 |
p.M1119I | SARC | 1 |
p.P533S | PAAD | 1 |
p.W99* | SKCM | 1 |
p.S1674F | SKCM | 1 |
p.S1798F | HNSC | 1 |
p.Q293K | SARC | 1 |
p.W429L | PRAD | 1 |
p.S193F | SKCM | 1 |
p.D1590N | SKCM | 1 |
p.K1131E | GBM | 1 |
p.G1707A | LUAD | 1 |
p.A191G | LUSC | 1 |
p.G90S | HNSC | 1 |
p.K1004R | STAD | 1 |
p.P533S | SKCM | 1 |
p.E296K | LUAD | 1 |
p.E1728D | UCEC | 1 |
p.R1243W | CHOL | 1 |
p.Q1135E | CESC | 1 |
p.D696Y | LUAD | 1 |
p.S1064I | UCEC | 1 |
p.D1166Y | UCEC | 1 |
p.H947Y | LUAD | 1 |
p.R832H | BRCA | 1 |
p.M1119I | SKCM | 1 |
p.K1254Q | LIHC | 1 |
p.Y205X | READ | 1 |
p.R1806T | BLCA | 1 |
p.P1277L | SKCM | 1 |
p.D142Y | LUAD | 1 |
p.L782Q | BRCA | 1 |
p.A960D | LIHC | 1 |
p.D1522Y | LUSC | 1 |
p.F982L | PAAD | 1 |
p.R254* | SKCM | 1 |
p.V801F | LUAD | 1 |
p.K349E | BLCA | 1 |
p.R1252Q | LGG | 1 |
p.597_598QG>HC | LUAD | 1 |
p.M371V | COAD | 1 |
p.K1574N | UCEC | 1 |
p.K269E | BLCA | 1 |
p.G444E | SKCM | 1 |
p.T779P | CESC | 1 |
p.Q596K | LUAD | 1 |
p.D327N | STAD | 1 |
p.Q1135E | LUSC | 1 |
p.R685C | BLCA | 1 |
p.D146N | BLCA | 1 |
p.A869T | COAD | 1 |
p.V1306M | HNSC | 1 |
p.R1356C | SKCM | 1 |
p.E402K | LUAD | 1 |
p.R685L | LUSC | 1 |
p.D172N | BLCA | 1 |
p.A539V | COAD | 1 |
p.R817K | SKCM | 1 |
p.P1427A | HNSC | 1 |
p.R823X | STAD | 1 |
p.G732V | LUSC | 1 |
p.P652S | THYM | 1 |
p.A1212V | SKCM | 1 |
p.R286C | SARC | 1 |
p.A646E | LUSC | 1 |
p.Q1135E | BRCA | 1 |
p.R888H | STAD | 1 |
p.D1775Y | HNSC | 1 |
p.E419K | STAD | 1 |
p.P1371L | SKCM | 1 |
p.G1730E | SKCM | 1 |
p.A929S | LUSC | 1 |
p.R840Q | BLCA | 1 |
p.D1435E | UCEC | 1 |
p.P1785H | LUSC | 1 |
p.R600W | LUAD | 1 |
p.Q596H | STAD | 1 |
p.R768C | SKCM | 1 |
p.D1521N | BLCA | 1 |
p.S306R | READ | 1 |
p.G1290* | LUSC | 1 |
p.E1118K | SKCM | 1 |
p.E933K | SKCM | 1 |
p.D1743Y | READ | 1 |
p.R1416K | UCEC | 1 |
p.E248K | BRCA | 1 |
p.K1259E | SKCM | 1 |
p.L76I | UCEC | 1 |
p.E763D | UCEC | 1 |
p.L826I | COAD | 1 |
p.V395A | LGG | 1 |
p.E119* | LUAD | 1 |
p.G1161R | PRAD | 1 |
p.R1243W | HNSC | 1 |
p.D1667N | GBM | 1 |
p.D1543H | BLCA | 1 |
p.K1455T | READ | 1 |
p.T1218N | LUAD | 1 |
p.F1786I | LUSC | 1 |
p.R1255W | LIHC | 1 |
p.M1I | STAD | 1 |
p.G981E | SKCM | 1 |
p.G1290V | LUSC | 1 |
p.M710I | SKCM | 1 |
p.P1785L | SKCM | 1 |
p.L1500F | SKCM | 1 |
p.G677R | LUSC | 1 |
p.E1634Q | HNSC | 1 |
p.L647F | COAD | 1 |
p.P132L | SKCM | 1 |
p.P157S | SKCM | 1 |
p.I608T | UCEC | 1 |
p.E85K | SKCM | 1 |
p.P583S | SKCM | 1 |
p.R1255W | THYM | 1 |
p.K1580N | ESCA | 1 |
p.E1463K | HNSC | 1 |
p.R1395Q | THYM | 1 |
p.W455S | LUAD | 1 |
p.F1424L | LUAD | 1 |
p.R1205Q | ESCA | 1 |
p.K1223I | SKCM | 1 |
p.R1215H | LUSC | 1 |
p.S1716F | CESC | 1 |
p.R1205* | UCEC | 1 |
p.L1386F | CESC | 1 |
p.E1043A | SKCM | 1 |
p.G69V | LUAD | 1 |
p.T1697A | LIHC | 1 |
p.E704D | LUAD | 1 |
p.L699I | UCEC | 1 |
p.R1080C | ESCA | 1 |
p.R254* | BRCA | 1 |
p.S309F | SKCM | 1 |
p.E1054K | SKCM | 1 |
p.N706K | LUAD | 1 |
p.L1148V | OV | 1 |
p.G1290R | STAD | 1 |
p.Q1790* | LUAD | 1 |
p.Q1487* | STAD | 1 |
p.A18S | LUAD | 1 |
p.G1804R | BLCA | 1 |
p.P230L | SKCM | 1 |
p.E1124D | STAD | 1 |
p.T1403M | UCEC | 1 |
p.V1402M | SKCM | 1 |
p.S541T | THYM | 1 |
p.K1578N | KIRC | 1 |
p.G43S | COAD | 1 |
p.P1732L | SKCM | 1 |
p.T228I | READ | 1 |
p.G1740V | LUAD | 1 |
p.R254X | SKCM | 1 |
p.D328V | LUAD | 1 |
p.R1584W | BLCA | 1 |
p.P251Q | LUSC | 1 |
p.N1552S | LUAD | 1 |
p.R636H | UCEC | 1 |
p.G1339W | PRAD | 1 |
p.C1286Y | LUAD | 1 |
p.E1222K | SKCM | 1 |
p.G384V | THCA | 1 |
p.C1201F | THYM | 1 |
p.Y134H | GBM | 1 |
p.T1010I | PRAD | 1 |
p.A173V | HNSC | 1 |
p.P160S | CESC | 1 |
p.C1496S | LUAD | 1 |
p.E1774* | LUSC | 1 |
p.R260L | LUAD | 1 |
p.T81K | LUAD | 1 |
p.D479N | OV | 1 |
p.R1252W | GBM | 1 |
p.P1459L | SKCM | 1 |
p.D689N | SKCM | 1 |
p.Q124* | SKCM | 1 |
p.R1080S | LUAD | 1 |
p.E248K | SARC | 1 |
p.R685G | CESC | 1 |
p.M1292V | LUAD | 1 |
p.R845Q | SKCM | 1 |
p.S136* | LUAD | 1 |
p.E924D | COAD | 1 |
p.E393K | SKCM | 1 |
p.D1192Y | ESCA | 1 |
p.M876I | SKCM | 1 |
p.D797N | SKCM | 1 |
p.H1579N | KIRC | 1 |
p.D1822E | LUAD | 1 |
p.I629M | CESC | 1 |
p.T1677A | LUAD | 1 |
p.P770S | SKCM | 1 |
p.M1538I | COAD | 1 |
p.P1389L | STAD | 1 |
p.E1054D | LIHC | 1 |
p.S398P | LUSC | 1 |
p.E248K | READ | 1 |
p.E1726D | STAD | 1 |
p.R558L | GBM | 1 |
p.S543P | THYM | 1 |
p.G1009E | SKCM | 1 |
p.R1027C | BLCA | 1 |
p.E1780K | UCEC | 1 |
p.R361C | BLCA | 1 |
p.R636C | SKCM | 1 |
p.S654A | HNSC | 1 |
p.R1461Q | UCEC | 1 |
p.E1747D | STAD | 1 |
p.H1057Y | SKCM | 1 |
p.R1049C | PRAD | 1 |
p.E1316V | HNSC | 1 |
p.R1015C | READ | 1 |
p.R842Q | PRAD | 1 |
p.Q597H | LUAD | 1 |
p.S1696Y | UCEC | 1 |
p.A316S | LUAD | 1 |
p.K718N | UCEC | 1 |
p.R1509L | KIRC | 1 |
p.C965R | LGG | 1 |
p.I440M | BLCA | 1 |
p.R840W | READ | 1 |
p.D1107G | KICH | 1 |
p.P975S | SARC | 1 |
p.T1697I | STAD | 1 |
p.S451R | STAD | 1 |
p.Q656H | GBM | 1 |
p.D1743N | SKCM | 1 |
p.L795S | LUAD | 1 |
p.R600Q | STAD | 1 |
p.R1442W | HNSC | 1 |
p.P335L | SKCM | 1 |
p.K281N | LUAD | 1 |
p.A716E | LUAD | 1 |
p.N542K | LUAD | 1 |
p.S273Y | COAD | 1 |
p.R1080H | LUAD | 1 |
p.R1191Q | READ | 1 |
p.S1309L | SKCM | 1 |
p.P594S | SKCM | 1 |
p.L967V | SARC | 1 |
p.R568M | LUAD | 1 |
p.Y702N | KIRC | 1 |
p.Q649H | COAD | 1 |
p.A1643G | LUAD | 1 |
p.K481R | PAAD | 1 |
p.E1354Q | DLBC | 1 |
p.E936K | SKCM | 1 |
p.I1623V | LUSC | 1 |
p.S1544Y | STAD | 1 |
p.G233R | CESC | 1 |
p.S1484L | SKCM | 1 |
p.R685C | LUAD | 1 |
p.E79K | LUAD | 1 |
p.K1038R | STAD | 1 |
p.P1481S | SKCM | 1 |
p.R1243W | COAD | 1 |
p.D96N | SKCM | 1 |
p.L1744I | UCEC | 1 |
p.E1258K | SKCM | 1 |
p.T445R | HNSC | 1 |
p.K1373N | UCEC | 1 |
p.R1145W | LUSC | 1 |
p.E740K | UCEC | 1 |
p.D172N | LUSC | 1 |
p.R1015H | LUAD | 1 |
p.R685C | GBM | 1 |
p.G33D | UCEC | 1 |
p.R1397H | UCEC | 1 |
p.R1049P | LIHC | 1 |
p.G4S | COAD | 1 |
p.A1476V | STAD | 1 |
p.Q1247L | LIHC | 1 |
p.I662N | STAD | 1 |
p.L1019M | STAD | 1 |
p.T218P | COAD | 1 |
p.A959V | THYM | 1 |
p.A614D | COAD | 1 |
p.A761P | UCEC | 1 |
p.E419K | SKCM | 1 |
p.D183Y | LUAD | 1 |
p.Q1490* | LUAD | 1 |
p.Q1135* | LUAD | 1 |
p.K1553N | UCEC | 1 |
p.E1642* | UCEC | 1 |
p.E1498D | UCEC | 1 |
p.R1080C | GBM | 1 |
p.D6N | SKCM | 1 |
p.P854S | SKCM | 1 |
p.A358S | LUAD | 1 |
p.T1673R | GBM | 1 |
p.E1222D | BLCA | 1 |
p.R1149Q | LUAD | 1 |
p.R1710K | ESCA | 1 |
p.L554V | BRCA | 1 |
p.S1018F | SKCM | 1 |
p.R823Q | STAD | 1 |
p.K1731R | STAD | 1 |
p.R793W | UCEC | 1 |
p.M235I | UCEC | 1 |
p.R685C | UCEC | 1 |
p.T992S | SKCM | 1 |
p.704_705EE>D* | LUAD | 1 |
p.E1275Q | CESC | 1 |
p.L883V | PRAD | 1 |
p.E419K | UCEC | 1 |
p.R873C | ACC | 1 |
p.R1375W | THCA | 1 |
p.K1131E | STAD | 1 |
p.M1812I | LUAD | 1 |
p.P1427T | LUAD | 1 |
p.W455C | LUAD | 1 |
p.L560I | UCS | 1 |
p.G605E | SKCM | 1 |
p.S21* | BLCA | 1 |
p.E1762D | UCEC | 1 |
p.V1599G | STAD | 1 |
p.E1451G | LUSC | 1 |
p.D996N | SKCM | 1 |
p.D1636G | CESC | 1 |
p.G598C | CHOL | 1 |
p.A453E | HNSC | 1 |
p.H1057R | STAD | 1 |
p.R1068C | SKCM | 1 |
p.M1415I | SKCM | 1 |
p.G1823W | LUAD | 1 |
p.D1636N | SKCM | 1 |
p.P854L | SKCM | 1 |
p.R1454C | ESCA | 1 |
p.R823* | STAD | 1 |
p.V347A | UCEC | 1 |
p.R1806K | SKCM | 1 |
p.E763K | HNSC | 1 |
p.R1244Q | ESCA | 1 |
p.1822_1823DG>EW | LUAD | 1 |
p.V297L | LUAD | 1 |
p.E1144K | SKCM | 1 |
p.G4S | BLCA | 1 |
p.A956S | LUAD | 1 |
p.E705* | LUAD | 1 |
p.P1370L | READ | 1 |
p.E216K | SKCM | 1 |
p.S343* | BLCA | 1 |
p.V200G | LUAD | 1 |
p.E1774K | SKCM | 1 |
p.I434V | LUAD | 1 |
p.A38V | COAD | 1 |
p.K1094N | STAD | 1 |
p.I440V | COAD | 1 |
p.L1348I | ESCA | 1 |
p.P687S | HNSC | 1 |
p.Q1487X | STAD | 1 |
p.S23L | SKCM | 1 |
p.D149Y | UCEC | 1 |
p.R1806I | ESCA | 1 |
p.D1330N | SKCM | 1 |
p.R873C | TGCT | 1 |
p.P1700T | LUAD | 1 |
p.L560F | SKCM | 1 |
p.E1780K | STAD | 1 |
p.G1722W | HNSC | 1 |
p.G977W | UCEC | 1 |
p.R1356C | COAD | 1 |
p.A1067V | PAAD | 1 |
p.L195F | KIRC | 1 |
p.S1073Y | UCEC | 1 |
p.H1382Y | SKCM | 1 |
p.D780N | SKCM | 1 |
p.D943Y | SARC | 1 |
p.R864M | SKCM | 1 |
p.R1252W | PRAD | 1 |
p.R873C | COAD | 1 |
p.A716D | LUAD | 1 |
p.G1378R | LUAD | 1 |
p.E968Q | BRCA | 1 |
p.R725Q | LUAD | 1 |
p.S857L | SARC | 1 |
p.D1772N | HNSC | 1 |
p.R768H | UCEC | 1 |
p.R1138L | KIRC | 1 |
p.K775* | LUAD | 1 |
p.D1667N | SKCM | 1 |
p.G1801R | SKCM | 1 |
p.R1191Q | UCEC | 1 |
p.D824Y | UCEC | 1 |
p.G875E | SKCM | 1 |
p.E1035K | HNSC | 1 |
p.D141G | UCEC | 1 |
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TissGeneCNV for TAF1L |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TAF1L |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TAF1L |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TAF1L |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TAF1L |
TissGeneDrug for TAF1L |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TAF1L |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |