TissGeneSummary for C9orf131 |
Gene summary |
Basic gene information | Gene symbol | C9orf131 |
Gene name | chromosome 9 open reading frame 131 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 9p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001040410.2, NM_001040411.2,NM_001040412.2,NM_001287391.1,NM_203299.3, | |
Description | uncharacterized protein C9orf131 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000174038 | ||
HPRD : 14616 | ||
Vega : OTTHUMG00000019853 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C9orf131 | |
BioGPS: 138724 | ||
Pathway | NCI Pathway Interaction Database: C9orf131 | |
KEGG: C9orf131 | ||
REACTOME: C9orf131 | ||
Pathway Commons: C9orf131 | ||
Context | iHOP: C9orf131 | |
ligand binding site mutation search in PubMed: C9orf131 | ||
UCL Cancer Institute: C9orf131 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C9orf131 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C9orf131 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for C9orf131 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C9orf131 |
TissGeneSNV for C9orf131 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G489R | SKCM | 2 |
p.P200R | OV | 1 |
p.E401D | CESC | 1 |
p.V657I | UCS | 1 |
p.A466V | STAD | 1 |
p.W453* | SKCM | 1 |
p.G16E | ESCA | 1 |
p.F196C | UCEC | 1 |
p.G756E | SKCM | 1 |
p.A86T | SKCM | 1 |
p.G618E | SARC | 1 |
p.R743S | LUAD | 1 |
p.S470L | UCEC | 1 |
p.A335S | LGG | 1 |
p.E697Q | BLCA | 1 |
p.P696L | HNSC | 1 |
p.R795W | ESCA | 1 |
p.H130R | SKCM | 1 |
p.K1065N | STAD | 1 |
p.P798T | LUAD | 1 |
p.G683E | SKCM | 1 |
p.W453C | GBM | 1 |
p.L350M | BRCA | 1 |
p.G297R | SKCM | 1 |
p.E415K | SKCM | 1 |
p.P339L | STAD | 1 |
p.G1014S | SKCM | 1 |
p.S164F | SKCM | 1 |
p.P200H | BLCA | 1 |
p.K944E | GBM | 1 |
p.P1015T | HNSC | 1 |
p.Q885R | ACC | 1 |
p.E303K | BLCA | 1 |
p.M452I | SKCM | 1 |
p.E264K | GBM | 1 |
p.L114M | LUAD | 1 |
p.P1005H | LUAD | 1 |
p.E401Q | HNSC | 1 |
p.P603L | HNSC | 1 |
p.D748A | COAD | 1 |
p.R795W | UCEC | 1 |
p.G370E | THYM | 1 |
p.W710X | SKCM | 1 |
p.E38D | COAD | 1 |
p.I172S | UCEC | 1 |
p.P903T | STAD | 1 |
p.Q632K | ACC | 1 |
p.S153Y | COAD | 1 |
p.H862N | PRAD | 1 |
p.R289W | LIHC | 1 |
p.E125K | SKCM | 1 |
p.S998I | LGG | 1 |
p.E713X | LIHC | 1 |
p.M525I | SKCM | 1 |
p.G569D | SKCM | 1 |
p.G265E | SKCM | 1 |
p.N361D | SKCM | 1 |
p.G413S | SKCM | 1 |
p.G642D | SKCM | 1 |
p.E105Q | BLCA | 1 |
p.E713* | LIHC | 1 |
p.N679S | STAD | 1 |
p.P916A | GBM | 1 |
p.M260I | SKCM | 1 |
p.G112E | SKCM | 1 |
p.Q1000* | UCEC | 1 |
p.G416R | SKCM | 1 |
p.S922* | BLCA | 1 |
p.G678E | SKCM | 1 |
p.C754R | GBM | 1 |
p.K331N | LUSC | 1 |
p.W783* | SKCM | 1 |
p.P487L | KIRC | 1 |
p.G192E | SKCM | 1 |
p.H203R | SKCM | 1 |
p.T500N | UCEC | 1 |
p.A729V | COAD | 1 |
p.L695V | HNSC | 1 |
p.S896R | LUAD | 1 |
p.S397X | READ | 1 |
p.D89N | CESC | 1 |
p.G486S | SKCM | 1 |
p.L286I | LUAD | 1 |
p.G751E | SKCM | 1 |
p.S249L | CESC | 1 |
p.S896R | LUSC | 1 |
p.S998N | LUAD | 1 |
p.G824V | LUAD | 1 |
p.D406N | BRCA | 1 |
p.G185E | SKCM | 1 |
p.Q1060R | STAD | 1 |
p.E672K | SKCM | 1 |
p.W424* | SKCM | 1 |
p.D406Y | CHOL | 1 |
p.G678R | SKCM | 1 |
p.K891N | BLCA | 1 |
p.G751R | SKCM | 1 |
p.A614D | BRCA | 1 |
p.G959E | SKCM | 1 |
p.A13T | SKCM | 1 |
p.G886E | SKCM | 1 |
p.Q993R | SKCM | 1 |
p.R1032L | LUSC | 1 |
p.F48S | UCEC | 1 |
p.H180Y | STAD | 1 |
p.G941S | SKCM | 1 |
p.A257S | ESCA | 1 |
p.T774A | LUAD | 1 |
p.E315D | UCEC | 1 |
p.E526A | LGG | 1 |
p.N434D | SKCM | 1 |
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TissGeneCNV for C9orf131 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C9orf131 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | LGG | TCGA-E1-5304-01A | VCP-C9orf131 | Out-of-Frame | chr9:35072333 | chr9:35042857 |
TCGAfusionPortal | PRADA | LGG | TCGA-E1-5304-01A | VCP-C9orf131 | Out-of-frame | Chr9:35072334 | Chr9:35042858 |
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TissGeneNet for C9orf131 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C9orf131 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C9orf131 |
TissGeneDrug for C9orf131 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C9orf131 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |