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| TissGeneSummary for PASD1 |
 Gene summary |
| Basic gene information | Gene symbol | PASD1 |
| Gene name | PAS domain containing 1 | |
| Synonyms | CT63|OXTES1 | |
| Cytomap | UCSC genome browser: Xq28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_173493.2, | |
| Description | PAS domain-containing protein 1cancer/testis antigen 63 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000166049 | ||
| HPRD : 06613 | ||
| Vega : OTTHUMG00000024169 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PASD1 | |
| BioGPS: 139135 | ||
| Pathway | NCI Pathway Interaction Database: PASD1 | |
| KEGG: PASD1 | ||
| REACTOME: PASD1 | ||
| Pathway Commons: PASD1 | ||
| Context | iHOP: PASD1 | |
| ligand binding site mutation search in PubMed: PASD1 | ||
| UCL Cancer Institute: PASD1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of PASD1 | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PASD1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for PASD1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PASD1 |
| TissGeneSNV for PASD1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S283F | SKCM | 3 |
| p.E375K | SKCM | 2 |
| p.P280L | SKCM | 2 |
| p.M338I | SKCM | 2 |
| p.N478T | STAD | 2 |
| p.D738N | SKCM | 2 |
| p.P98S | SKCM | 2 |
| p.L464F | SKCM | 2 |
| p.P343S | SKCM | 2 |
| p.G171E | SKCM | 2 |
| p.L209P | LGG | 1 |
| p.V419I | GBM | 1 |
| p.S262Y | GBM | 1 |
| p.K92T | STAD | 1 |
| p.Q510H | UCEC | 1 |
| p.R216K | UCEC | 1 |
| p.E227D | HNSC | 1 |
| p.L78S | SKCM | 1 |
| p.K379T | STAD | 1 |
| p.E734* | HNSC | 1 |
| p.P277S | HNSC | 1 |
| p.E126K | LGG | 1 |
| p.E559D | UCEC | 1 |
| p.A354T | SARC | 1 |
| p.M515L | LIHC | 1 |
| p.E126K | UCEC | 1 |
| p.D87N | LUAD | 1 |
| p.I54V | ESCA | 1 |
| p.K531N | UCEC | 1 |
| p.P673L | SARC | 1 |
| p.Q522H | UCEC | 1 |
| p.S346T | LUAD | 1 |
| p.D324N | SKCM | 1 |
| p.A236V | STAD | 1 |
| p.V144A | KICH | 1 |
| p.M515I | UCEC | 1 |
| p.F624L | LUAD | 1 |
| p.E305K | COAD | 1 |
| p.P571Q | LUAD | 1 |
| p.P670S | SKCM | 1 |
| p.E88K | SKCM | 1 |
| p.S279Y | READ | 1 |
| p.E545K | SKCM | 1 |
| p.M45I | SKCM | 1 |
| p.A354T | BRCA | 1 |
| p.Q694* | PRAD | 1 |
| p.L587Q | HNSC | 1 |
| p.D31H | LUAD | 1 |
| p.R19K | SKCM | 1 |
| p.Q727H | STAD | 1 |
| p.A229T | PAAD | 1 |
| p.R166Q | SKCM | 1 |
| p.T270R | PRAD | 1 |
| p.D243V | LUAD | 1 |
| p.V36G | STAD | 1 |
| p.A401S | LIHC | 1 |
| p.E561D | ESCA | 1 |
| p.Q588* | UCEC | 1 |
| p.E643K | LUSC | 1 |
| p.W23R | LUAD | 1 |
| p.L100I | BRCA | 1 |
| p.D300Y | LUAD | 1 |
| p.I24M | STAD | 1 |
| p.D274N | SKCM | 1 |
| p.D768Y | LUSC | 1 |
| p.S463F | UCEC | 1 |
| p.E557K | UCEC | 1 |
| p.P648H | LUAD | 1 |
| p.E695Q | BLCA | 1 |
| p.I690T | READ | 1 |
| p.E557G | UCEC | 1 |
| p.Q584H | KIRC | 1 |
| p.E248* | LUAD | 1 |
| p.E248* | UCEC | 1 |
| p.M553I | LUAD | 1 |
| p.R444W | UCEC | 1 |
| p.Q584R | PRAD | 1 |
| p.R691W | UCEC | 1 |
| p.N34Y | LUAD | 1 |
| p.E292K | BLCA | 1 |
| p.E491D | DLBC | 1 |
| p.E71D | HNSC | 1 |
| p.R417C | SARC | 1 |
| p.L176I | UCEC | 1 |
| p.L464V | LUAD | 1 |
| p.V593L | LUAD | 1 |
| p.E734K | LUAD | 1 |
| p.I237M | HNSC | 1 |
| p.Q740H | SKCM | 1 |
| p.V509M | COAD | 1 |
| p.E208K | SKCM | 1 |
| p.P277S | STAD | 1 |
| p.A354T | UCEC | 1 |
| p.T679A | LGG | 1 |
| p.K450N | LUAD | 1 |
| p.A439T | CESC | 1 |
| p.A235D | LUAD | 1 |
| p.S307L | UCEC | 1 |
| p.L409F | SKCM | 1 |
| p.Q316E | PRAD | 1 |
| p.D312G | LIHC | 1 |
| p.E469K | SKCM | 1 |
| p.S262F | SKCM | 1 |
| p.T37M | LUAD | 1 |
| p.E254D | UCEC | 1 |
| p.S187L | BLCA | 1 |
| p.P673S | SKCM | 1 |
| p.E193K | SKCM | 1 |
| p.P590T | COAD | 1 |
| p.V420I | ESCA | 1 |
| p.S200L | CESC | 1 |
| p.A401S | LUAD | 1 |
| p.G74D | UCEC | 1 |
| p.D339N | SKCM | 1 |
| p.E107K | SKCM | 1 |
| p.S666F | SKCM | 1 |
| p.F477L | LUAD | 1 |
| p.Q437K | LUAD | 1 |
| p.N478T | ESCA | 1 |
| p.Y748X | COAD | 1 |
| p.G115E | SKCM | 1 |
| p.L532M | OV | 1 |
| p.F157V | ESCA | 1 |
| p.E317K | SKCM | 1 |
| p.E634K | SKCM | 1 |
| p.G735E | SKCM | 1 |
| p.D688Y | KIRC | 1 |
| p.A194V | OV | 1 |
| p.P413R | LUSC | 1 |
| p.E305K | LUAD | 1 |
| p.G735R | SKCM | 1 |
| p.R537W | UCEC | 1 |
| p.F205L | UCEC | 1 |
| p.E765G | BRCA | 1 |
| p.M1I | GBM | 1 |
| p.N707T | ESCA | 1 |
| p.D712N | SKCM | 1 |
| p.L284* | SKCM | 1 |
| p.M320I | LUAD | 1 |
| p.L464F | UCEC | 1 |
| p.V419I | COAD | 1 |
| p.D342N | SKCM | 1 |
| p.A747T | UCEC | 1 |
| p.F306L | PAAD | 1 |
| p.D345N | SKCM | 1 |
| p.S426Y | UCEC | 1 |
| p.G579R | SKCM | 1 |
| p.Y250D | LUAD | 1 |
| p.F33Y | SKCM | 1 |
| p.P25L | LGG | 1 |
| p.H448Y | COAD | 1 |
| p.E561K | KIRC | 1 |
| p.G217R | SKCM | 1 |
| p.D738Y | HNSC | 1 |
| p.Q213E | COAD | 1 |
| p.D345N | HNSC | 1 |
| p.F108C | COAD | 1 |
| p.Q522H | SARC | 1 |
| p.S697C | LIHC | 1 |
| p.S17F | HNSC | 1 |
| p.T708N | UCEC | 1 |
| p.I585T | STAD | 1 |
| p.K573T | UCS | 1 |
| p.A245S | KIRP | 1 |
| p.G350R | SKCM | 1 |
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| TissGeneCNV for PASD1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PASD1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-GM-A2DH-01A | TEC-PASD1 | 5UTR-CDS | Chr4:48271769 | ChrX:150789402 |
| TCGAfusionPortal | PRADA | KIRC | TCGA-CJ-5681-01A | DCX-PASD1 | Out-of-frame | ChrX:110574147 | ChrX:150828185 |
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| TissGeneNet for PASD1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| COAD (tumor) | COAD (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| KICH (tumor) | KICH (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| STAD (tumor) | STAD (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| THCA (tumor) | THCA (normal) |
| PASD1, SUMO2 (tumor) | PASD1, SUMO2 (normal) |
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| TissGeneProg for PASD1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PASD1 |
| TissGeneDrug for PASD1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PASD1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0079744 | Diffuse Large B-Cell Lymphoma | 2 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 2 | BeFree |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0026764 | Multiple Myeloma | 1 | BeFree |
| umls:C0039614 | Tetanus | 1 | BeFree |
| umls:C0242596 | Neoplasm, Residual | 1 | BeFree |
| umls:C3811653 | Experimental Organism Basal Cell Carcinoma | 1 | BeFree |
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