TissGeneSummary for CTCFL |
Gene summary |
Basic gene information | Gene symbol | CTCFL |
Gene name | CCCTC-binding factor (zinc finger protein)-like | |
Synonyms | BORIS|CT27|CTCF-T|HMGB1L1|dJ579F20.2 | |
Cytomap | UCSC genome browser: 20q13.31 | |
Type of gene | protein-coding | |
RefGenes | NM_001269040.1, NM_001269041.1,NM_001269042.1,NM_001269043.1,NM_001269044.1, NM_001269045.1,NM_001269046.1,NM_001269047.1,NM_001269048.1, NM_001269049.1,NM_001269050.1,NM_001269051.1,NM_001269052.1, NM_001269054.1,NM_001269055.1,NM_080618.3,NR_072975.1, | |
Description | BORIS-like proteinCTCF paralogCTCF-like proteinHMG-1L1brother of the regulator of imprinted sitescancer/testis antigen 27putative high mobility group protein 1-like 1putative high mobility group protein B1-like 1transcriptional repressor CTCFLzin | |
Modification date | 20141207 | |
dbXrefs | MIM : 607022 | |
HGNC : HGNC | ||
Ensembl : ENSG00000124092 | ||
HPRD : 09512 | ||
Vega : OTTHUMG00000032829 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CTCFL | |
BioGPS: 140690 | ||
Pathway | NCI Pathway Interaction Database: CTCFL | |
KEGG: CTCFL | ||
REACTOME: CTCFL | ||
Pathway Commons: CTCFL | ||
Context | iHOP: CTCFL | |
ligand binding site mutation search in PubMed: CTCFL | ||
UCL Cancer Institute: CTCFL | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CTCFL | Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies. Hoffmann MJ, Müller M, Engers R, Schulz WA. Biochem Pharmacol. 2006 Nov 30;72(11):1577-88. Epub 2006 Jul 18. (pmid:16854382) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0010628 | positive regulation of gene expression | 18413740 | GO:0045893 | positive regulation of transcription, DNA-templated | 18413740 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 16140944 | GO:0010628 | positive regulation of gene expression | 18413740 | GO:0045893 | positive regulation of transcription, DNA-templated | 18413740 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 16140944 |
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TissGeneExp for CTCFL |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.084037452 | -1.351619411 | 1.435656863 | 5.39E-06 | 1.26E-05 |
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TissGene-miRNA for CTCFL |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CTCFL |
TissGeneSNV for CTCFL |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R274C | SKCM | 2 |
p.V112E | BRCA | 1 |
p.G548C | HNSC | 1 |
p.Q104* | LUSC | 1 |
p.A135T | STAD | 1 |
p.Q139K | LUAD | 1 |
p.D317N | SKCM | 1 |
p.E597K | SKCM | 1 |
p.R506C | SKCM | 1 |
p.E29K | SKCM | 1 |
p.P23L | STAD | 1 |
p.F583I | SARC | 1 |
p.E187G | KIRP | 1 |
p.S243C | STAD | 1 |
p.G569E | STAD | 1 |
p.R362* | SKCM | 1 |
p.D317N | BLCA | 1 |
p.T337A | UCS | 1 |
p.R470C | COAD | 1 |
p.Q371H | KIRP | 1 |
p.C373F | SARC | 1 |
p.V60I | STAD | 1 |
p.P543S | SKCM | 1 |
p.E228* | HNSC | 1 |
p.G510A | UCEC | 1 |
p.E18* | UCEC | 1 |
p.H480R | HNSC | 1 |
p.R406C | STAD | 1 |
p.R330* | BLCA | 1 |
p.R456C | SKCM | 1 |
p.E339K | SKCM | 1 |
p.T435I | SKCM | 1 |
p.R301W | ESCA | 1 |
p.R507L | THYM | 1 |
p.R362X | SKCM | 1 |
p.C344Y | LGG | 1 |
p.G411E | SKCM | 1 |
p.M447V | COAD | 1 |
p.E647K | SKCM | 1 |
p.C466F | LUAD | 1 |
p.E399K | SKCM | 1 |
p.H416R | LUAD | 1 |
p.R387H | ESCA | 1 |
p.K358E | ACC | 1 |
p.D381H | BLCA | 1 |
p.T465I | LUAD | 1 |
p.H532Q | ESCA | 1 |
p.E596Q | LUAD | 1 |
p.E20K | SKCM | 1 |
p.H430R | HNSC | 1 |
p.D488N | SKCM | 1 |
p.E407K | SKCM | 1 |
p.H41N | LUAD | 1 |
p.P493S | SKCM | 1 |
p.G519E | SKCM | 1 |
p.R301W | BRCA | 1 |
p.A49S | LUSC | 1 |
p.R506H | UCEC | 1 |
p.R499C | OV | 1 |
p.S72L | STAD | 1 |
p.G255E | SKCM | 1 |
p.E614K | UCEC | 1 |
p.E419K | SKCM | 1 |
p.D317N | UCEC | 1 |
p.V108M | UCEC | 1 |
p.T296M | LGG | 1 |
p.G612E | SKCM | 1 |
p.E76K | LUAD | 1 |
p.T84M | STAD | 1 |
p.S89F | SKCM | 1 |
p.R470C | UCEC | 1 |
p.E646Q | LUAD | 1 |
p.G598S | SKCM | 1 |
p.G548S | SKCM | 1 |
p.E38Q | CESC | 1 |
p.R380T | KIRP | 1 |
p.K254N | COAD | 1 |
p.K28R | UCEC | 1 |
p.R301W | PAAD | 1 |
p.E214K | SKCM | 1 |
p.R301W | STAD | 1 |
p.K385* | BLCA | 1 |
p.V224E | LUAD | 1 |
p.R368S | LIHC | 1 |
p.R42Q | CHOL | 1 |
p.E469K | SKCM | 1 |
p.R507G | SKCM | 1 |
p.E175D | STAD | 1 |
p.I559N | SKCM | 1 |
p.I591T | OV | 1 |
p.H514L | LUAD | 1 |
p.S515L | SKCM | 1 |
p.E76V | BRCA | 1 |
p.L357F | LUAD | 1 |
p.R368H | ACC | 1 |
p.E50Q | COAD | 1 |
p.P23S | LUAD | 1 |
p.E614* | LUAD | 1 |
p.D317N | LUAD | 1 |
p.Y493* | LUAD | 1 |
p.D613G | STAD | 1 |
p.I215N | SKCM | 1 |
p.G255* | UCEC | 1 |
p.L47W | SKCM | 1 |
p.T256I | SKCM | 1 |
p.L658I | UCEC | 1 |
p.E423K | READ | 1 |
p.F464V | SKCM | 1 |
p.Y443* | LUAD | 1 |
p.A236T | UCEC | 1 |
p.T205A | SKCM | 1 |
p.S363C | LUAD | 1 |
p.E423K | SKCM | 1 |
p.M263I | LUAD | 1 |
p.G555R | SKCM | 1 |
p.Q131K | LUAD | 1 |
p.G366E | KIRC | 1 |
p.C375Y | UCEC | 1 |
p.S565L | SKCM | 1 |
p.D563G | STAD | 1 |
p.S45R | STAD | 1 |
p.D58E | OV | 1 |
p.C491Y | UCEC | 1 |
p.G562E | SKCM | 1 |
p.R51H | LUAD | 1 |
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TissGeneCNV for CTCFL |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CTCFL |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CTCFL |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CTCFL |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CTCFL |
TissGeneDrug for CTCFL |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CTCFL |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0153594 | Malignant neoplasm of testis | 10 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 5 | BeFree |
umls:C0684249 | Carcinoma of lung | 5 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree,GAD |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 3 | BeFree |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 3 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 3 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
umls:C0016719 | Friedreich Ataxia | 2 | BeFree |
umls:C0024121 | Lung Neoplasms | 2 | BeFree,LHGDN |
umls:C0476089 | Endometrial Carcinoma | 2 | BeFree |
umls:C0919267 | ovarian neoplasm | 2 | BeFree,LHGDN |
umls:C0000768 | Congenital Abnormality | 1 | BeFree |
umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree,LHGDN |
umls:C0027654 | Embryonal Neoplasm | 1 | BeFree |
umls:C0042138 | Uterine Neoplasms | 1 | LHGDN |
umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
umls:C0153567 | Uterine Cancer | 1 | BeFree |
umls:C0175693 | Russell-Silver syndrome | 1 | BeFree |
umls:C0205851 | Germ cell tumor | 1 | BeFree |
umls:C0206731 | Angiofibroma | 1 | BeFree |
umls:C0346429 | Multiple malignancy | 1 | BeFree |
umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C0751688 | Malignant Squamous Cell Neoplasm | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1334603 | Malignant Mixed Mesodermal (Mullerian) Tumor | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |