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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CTCFL
check button Gene summary
Basic gene informationGene symbolCTCFL
Gene nameCCCTC-binding factor (zinc finger protein)-like
SynonymsBORIS|CT27|CTCF-T|HMGB1L1|dJ579F20.2
CytomapUCSC genome browser: 20q13.31
Type of geneprotein-coding
RefGenesNM_001269040.1,
NM_001269041.1,NM_001269042.1,NM_001269043.1,NM_001269044.1,
NM_001269045.1,NM_001269046.1,NM_001269047.1,NM_001269048.1,
NM_001269049.1,NM_001269050.1,NM_001269051.1,NM_001269052.1,
NM_001269054.1,NM_001269055.1,NM_080618.3,NR_072975.1,
DescriptionBORIS-like proteinCTCF paralogCTCF-like proteinHMG-1L1brother of the regulator of imprinted sitescancer/testis antigen 27putative high mobility group protein 1-like 1putative high mobility group protein B1-like 1transcriptional repressor CTCFLzin
Modification date20141207
dbXrefs MIM : 607022
HGNC : HGNC
Ensembl : ENSG00000124092
HPRD : 09512
Vega : OTTHUMG00000032829
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CTCFL
BioGPS: 140690
PathwayNCI Pathway Interaction Database: CTCFL
KEGG: CTCFL
REACTOME: CTCFL
Pathway Commons: CTCFL
ContextiHOP: CTCFL
ligand binding site mutation search in PubMed: CTCFL
UCL Cancer Institute: CTCFL
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of CTCFLEpigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies. Hoffmann MJ, Müller M, Engers R, Schulz WA. Biochem Pharmacol. 2006 Nov 30;72(11):1577-88. Epub 2006 Jul 18. (pmid:16854382)
go to article
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0010628positive regulation of gene expression18413740
GO:0045893positive regulation of transcription, DNA-templated18413740
GO:0045944positive regulation of transcription from RNA polymerase II promoter16140944
GO:0010628positive regulation of gene expression18413740
GO:0045893positive regulation of transcription, DNA-templated18413740
GO:0045944positive regulation of transcription from RNA polymerase II promoter16140944


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TissGeneExp for CTCFL

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUSC0.084037452-1.3516194111.4356568635.39E-061.26E-05


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TissGene-miRNA for CTCFL

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CTCFL
TissGeneSNV for CTCFL

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R274CSKCM2
p.V112EBRCA1
p.G548CHNSC1
p.Q104*LUSC1
p.A135TSTAD1
p.Q139KLUAD1
p.D317NSKCM1
p.E597KSKCM1
p.R506CSKCM1
p.E29KSKCM1
p.P23LSTAD1
p.F583ISARC1
p.E187GKIRP1
p.S243CSTAD1
p.G569ESTAD1
p.R362*SKCM1
p.D317NBLCA1
p.T337AUCS1
p.R470CCOAD1
p.Q371HKIRP1
p.C373FSARC1
p.V60ISTAD1
p.P543SSKCM1
p.E228*HNSC1
p.G510AUCEC1
p.E18*UCEC1
p.H480RHNSC1
p.R406CSTAD1
p.R330*BLCA1
p.R456CSKCM1
p.E339KSKCM1
p.T435ISKCM1
p.R301WESCA1
p.R507LTHYM1
p.R362XSKCM1
p.C344YLGG1
p.G411ESKCM1
p.M447VCOAD1
p.E647KSKCM1
p.C466FLUAD1
p.E399KSKCM1
p.H416RLUAD1
p.R387HESCA1
p.K358EACC1
p.D381HBLCA1
p.T465ILUAD1
p.H532QESCA1
p.E596QLUAD1
p.E20KSKCM1
p.H430RHNSC1
p.D488NSKCM1
p.E407KSKCM1
p.H41NLUAD1
p.P493SSKCM1
p.G519ESKCM1
p.R301WBRCA1
p.A49SLUSC1
p.R506HUCEC1
p.R499COV1
p.S72LSTAD1
p.G255ESKCM1
p.E614KUCEC1
p.E419KSKCM1
p.D317NUCEC1
p.V108MUCEC1
p.T296MLGG1
p.G612ESKCM1
p.E76KLUAD1
p.T84MSTAD1
p.S89FSKCM1
p.R470CUCEC1
p.E646QLUAD1
p.G598SSKCM1
p.G548SSKCM1
p.E38QCESC1
p.R380TKIRP1
p.K254NCOAD1
p.K28RUCEC1
p.R301WPAAD1
p.E214KSKCM1
p.R301WSTAD1
p.K385*BLCA1
p.V224ELUAD1
p.R368SLIHC1
p.R42QCHOL1
p.E469KSKCM1
p.R507GSKCM1
p.E175DSTAD1
p.I559NSKCM1
p.I591TOV1
p.H514LLUAD1
p.S515LSKCM1
p.E76VBRCA1
p.L357FLUAD1
p.R368HACC1
p.E50QCOAD1
p.P23SLUAD1
p.E614*LUAD1
p.D317NLUAD1
p.Y493*LUAD1
p.D613GSTAD1
p.I215NSKCM1
p.G255*UCEC1
p.L47WSKCM1
p.T256ISKCM1
p.L658IUCEC1
p.E423KREAD1
p.F464VSKCM1
p.Y443*LUAD1
p.A236TUCEC1
p.T205ASKCM1
p.S363CLUAD1
p.E423KSKCM1
p.M263ILUAD1
p.G555RSKCM1
p.Q131KLUAD1
p.G366EKIRC1
p.C375YUCEC1
p.S565LSKCM1
p.D563GSTAD1
p.S45RSTAD1
p.D58EOV1
p.C491YUCEC1
p.G562ESKCM1
p.R51HLUAD1


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TissGeneCNV for CTCFL

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CTCFL

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for CTCFL

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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COAD (tumor)COAD (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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HNSC (tumor)HNSC (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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KICH (tumor)KICH (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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KIRC (tumor)KIRC (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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KIRP (tumor)KIRP (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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LIHC (tumor)LIHC (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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LUAD (tumor)LUAD (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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LUSC (tumor)LUSC (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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PRAD (tumor)PRAD (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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STAD (tumor)STAD (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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THCA (tumor)THCA (normal)
CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (tumor)CTCFL, BRCA1, SP1, HIST2H2AC, HIST1H3A, TCF4, PRMT7, HIST1H1A (normal)
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TissGeneProg for CTCFL

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CTCFL
TissGeneDrug for CTCFL

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CTCFL

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0153594Malignant neoplasm of testis10BeFree
umls:C0242379Malignant neoplasm of lung5BeFree
umls:C0684249Carcinoma of lung5BeFree
umls:C0006142Malignant neoplasm of breast4BeFree,GAD
umls:C0678222Breast Carcinoma4BeFree
umls:C0029925Ovarian Carcinoma3BeFree
umls:C0596263Carcinogenesis3BeFree
umls:C0677886Epithelial ovarian cancer3BeFree
umls:C1140680Malignant neoplasm of ovary3BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0016719Friedreich Ataxia2BeFree
umls:C0024121Lung Neoplasms2BeFree,LHGDN
umls:C0476089Endometrial Carcinoma2BeFree
umls:C0919267ovarian neoplasm2BeFree,LHGDN
umls:C0000768Congenital Abnormality1BeFree
umls:C0007103Malignant neoplasm of endometrium1BeFree
umls:C0014859Esophageal Neoplasms1BeFree
umls:C0023449Acute lymphocytic leukemia1BeFree
umls:C0023452Leukemia, Lymphocytic, Acute, L11BeFree
umls:C0025202melanoma1BeFree,LHGDN
umls:C0027654Embryonal Neoplasm1BeFree
umls:C0042138Uterine Neoplasms1LHGDN
umls:C0152018Esophageal carcinoma1BeFree
umls:C0153567Uterine Cancer1BeFree
umls:C0175693Russell-Silver syndrome1BeFree
umls:C0205851Germ cell tumor1BeFree
umls:C0206731Angiofibroma1BeFree
umls:C0346429Multiple malignancy1BeFree
umls:C0546837Malignant neoplasm of esophagus1BeFree
umls:C0686619Secondary malignant neoplasm of lymph node1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0751688Malignant Squamous Cell Neoplasm1BeFree
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1334603Malignant Mixed Mesodermal (Mullerian) Tumor1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1883486Uterine Corpus Cancer1BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1BeFree