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| TissGeneSummary for NRSN1 |
 Gene summary |
| Basic gene information | Gene symbol | NRSN1 |
| Gene name | neurensin 1 | |
| Synonyms | VMP|p24 | |
| Cytomap | UCSC genome browser: 6p22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_080723.4, | |
| Description | neurensin-1neuro-p24vesicular membrain protein p24vesicular membrane protein of 24 kDavesicular membrane protein p24 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000152954 | ||
| HPRD : 18285 | ||
| Vega : OTTHUMG00000016406 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NRSN1 | |
| BioGPS: 140767 | ||
| Pathway | NCI Pathway Interaction Database: NRSN1 | |
| KEGG: NRSN1 | ||
| REACTOME: NRSN1 | ||
| Pathway Commons: NRSN1 | ||
| Context | iHOP: NRSN1 | |
| ligand binding site mutation search in PubMed: NRSN1 | ||
| UCL Cancer Institute: NRSN1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of NRSN1 | ||
| Description by TissGene annotations | Protective TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for NRSN1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -1.727463512 | 0.739648027 | -2.467111538 | 7.09E-09 | 6.64E-08 |
| STAD | -1.794122887 | 0.202330238 | -1.996453125 | 0.000367 | 0.0023855 |
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| TissGene-miRNA for NRSN1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-135a-5p | MIMAT0000428 | 0.049 | -0.27 | 56 |
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| TissGeneMut for NRSN1 |
| TissGeneSNV for NRSN1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R157Q | SKCM | 2 |
| p.T128S | THYM | 1 |
| p.E95K | BLCA | 1 |
| p.K116Q | LUAD | 1 |
| p.G83D | STAD | 1 |
| p.E91K | LUSC | 1 |
| p.Y44N | LUAD | 1 |
| p.R56G | ESCA | 1 |
| p.L117M | LUAD | 1 |
| p.E147D | SKCM | 1 |
| p.T128M | ESCA | 1 |
| p.P172S | SKCM | 1 |
| p.S5I | LUAD | 1 |
| p.V82L | HNSC | 1 |
| p.A39T | LGG | 1 |
| p.L75I | LUSC | 1 |
| p.D102G | HNSC | 1 |
| p.N188S | LIHC | 1 |
| p.K178N | UCEC | 1 |
| p.E95K | LUAD | 1 |
| p.R56W | LUAD | 1 |
| p.R52T | BLCA | 1 |
| p.E43D | LUSC | 1 |
| p.E176K | SKCM | 1 |
| p.L134M | LUAD | 1 |
| p.V100M | STAD | 1 |
| p.G76E | SKCM | 1 |
| p.P174S | UCEC | 1 |
| p.R185K | LUAD | 1 |
| p.E147K | SKCM | 1 |
| p.A171V | UCEC | 1 |
| p.R23C | PAAD | 1 |
| p.K148* | SKCM | 1 |
| p.E91K | PAAD | 1 |
| p.L193M | LUAD | 1 |
| p.D97N | SKCM | 1 |
| p.S40L | SKCM | 1 |
| p.I41S | READ | 1 |
| p.E95K | PAAD | 1 |
| p.V186A | SARC | 1 |
| p.V138A | SKCM | 1 |
| p.T70I | BLCA | 1 |
| p.G19S | SKCM | 1 |
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| TissGeneCNV for NRSN1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NRSN1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | PRAD | TCGA-VP-A87K-01A | SLC22A23-NRSN1 | CDS-5UTR | Chr6:3410422 | Chr6:24134547 |
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| TissGeneNet for NRSN1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| COAD (tumor) | COAD (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| KICH (tumor) | KICH (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| STAD (tumor) | STAD (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| THCA (tumor) | THCA (normal) |
| NRSN1, SPINK1 (tumor) | NRSN1, SPINK1 (normal) |
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| TissGeneProg for NRSN1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NRSN1 |
| TissGeneDrug for NRSN1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NRSN1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019693 | HIV Infections | 314 | BeFree |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 7 | BeFree |
| umls:C0019163 | Hepatitis B | 4 | BeFree |
| umls:C0041296 | Tuberculosis | 4 | BeFree |
| umls:C0001175 | Acquired Immunodeficiency Syndrome | 3 | BeFree |
| umls:C0006023 | Borna Disease | 3 | BeFree |
| umls:C0024198 | Lyme Disease | 3 | BeFree |
| umls:C0042749 | Viremia | 3 | BeFree |
| umls:C0343752 | Acute HIV infection | 3 | BeFree |
| umls:C0008354 | Cholera | 2 | BeFree |
| umls:C0023418 | leukemia | 2 | BeFree |
| umls:C0023492 | Leukemia, T-Cell | 2 | BeFree |
| umls:C0036341 | Schizophrenia | 2 | BeFree |
| umls:C0042769 | Virus Diseases | 2 | BeFree |
| umls:C0206019 | HIV Encephalopathy | 2 | BeFree |
| umls:C0276548 | HIV encephalitis | 2 | BeFree |
| umls:C0525045 | Mood Disorders | 2 | BeFree |
| umls:C0004936 | Mental disorders | 1 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 1 | CTD_human |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0011226 | Hepatitis D Infection | 1 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0022638 | Ketosis | 1 | BeFree |
| umls:C0024302 | Reticulosarcoma | 1 | BeFree |
| umls:C0024530 | Malaria | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree,GAD |
| umls:C0038826 | Superinfection | 1 | BeFree |
| umls:C0039614 | Tetanus | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042109 | Urticaria | 1 | BeFree |
| umls:C0221232 | Welts | 1 | BeFree |
| umls:C0235031 | Neurologic Symptoms | 1 | BeFree |
| umls:C0242723 | Parasitemia | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0343751 | Asymptomatic human immunodeficiency virus infection | 1 | BeFree |
| umls:C0349637 | Common acute lymphoblastic leukemia | 1 | BeFree |
| umls:C0476254 | Dyslexia | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0948192 | Primary infection NOS | 1 | BeFree |
| umls:C1142553 | Primary HIV infection | 1 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree |
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