TissGeneSummary for NRSN1 |
Gene summary |
Basic gene information | Gene symbol | NRSN1 |
Gene name | neurensin 1 | |
Synonyms | VMP|p24 | |
Cytomap | UCSC genome browser: 6p22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_080723.4, | |
Description | neurensin-1neuro-p24vesicular membrain protein p24vesicular membrane protein of 24 kDavesicular membrane protein p24 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000152954 | ||
HPRD : 18285 | ||
Vega : OTTHUMG00000016406 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NRSN1 | |
BioGPS: 140767 | ||
Pathway | NCI Pathway Interaction Database: NRSN1 | |
KEGG: NRSN1 | ||
REACTOME: NRSN1 | ||
Pathway Commons: NRSN1 | ||
Context | iHOP: NRSN1 | |
ligand binding site mutation search in PubMed: NRSN1 | ||
UCL Cancer Institute: NRSN1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of NRSN1 | ||
Description by TissGene annotations | Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for NRSN1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -1.727463512 | 0.739648027 | -2.467111538 | 7.09E-09 | 6.64E-08 |
STAD | -1.794122887 | 0.202330238 | -1.996453125 | 0.000367 | 0.0023855 |
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TissGene-miRNA for NRSN1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
UCS | hsa-miR-135a-5p | MIMAT0000428 | 0.049 | -0.27 | 56 |
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TissGeneMut for NRSN1 |
TissGeneSNV for NRSN1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R157Q | SKCM | 2 |
p.T128S | THYM | 1 |
p.E95K | BLCA | 1 |
p.K116Q | LUAD | 1 |
p.G83D | STAD | 1 |
p.E91K | LUSC | 1 |
p.Y44N | LUAD | 1 |
p.R56G | ESCA | 1 |
p.L117M | LUAD | 1 |
p.E147D | SKCM | 1 |
p.T128M | ESCA | 1 |
p.P172S | SKCM | 1 |
p.S5I | LUAD | 1 |
p.V82L | HNSC | 1 |
p.A39T | LGG | 1 |
p.L75I | LUSC | 1 |
p.D102G | HNSC | 1 |
p.N188S | LIHC | 1 |
p.K178N | UCEC | 1 |
p.E95K | LUAD | 1 |
p.R56W | LUAD | 1 |
p.R52T | BLCA | 1 |
p.E43D | LUSC | 1 |
p.E176K | SKCM | 1 |
p.L134M | LUAD | 1 |
p.V100M | STAD | 1 |
p.G76E | SKCM | 1 |
p.P174S | UCEC | 1 |
p.R185K | LUAD | 1 |
p.E147K | SKCM | 1 |
p.A171V | UCEC | 1 |
p.R23C | PAAD | 1 |
p.K148* | SKCM | 1 |
p.E91K | PAAD | 1 |
p.L193M | LUAD | 1 |
p.D97N | SKCM | 1 |
p.S40L | SKCM | 1 |
p.I41S | READ | 1 |
p.E95K | PAAD | 1 |
p.V186A | SARC | 1 |
p.V138A | SKCM | 1 |
p.T70I | BLCA | 1 |
p.G19S | SKCM | 1 |
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TissGeneCNV for NRSN1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NRSN1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | PRAD | TCGA-VP-A87K-01A | SLC22A23-NRSN1 | CDS-5UTR | Chr6:3410422 | Chr6:24134547 |
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TissGeneNet for NRSN1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NRSN1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NRSN1 |
TissGeneDrug for NRSN1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NRSN1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019693 | HIV Infections | 314 | BeFree |
umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 7 | BeFree |
umls:C0019163 | Hepatitis B | 4 | BeFree |
umls:C0041296 | Tuberculosis | 4 | BeFree |
umls:C0001175 | Acquired Immunodeficiency Syndrome | 3 | BeFree |
umls:C0006023 | Borna Disease | 3 | BeFree |
umls:C0024198 | Lyme Disease | 3 | BeFree |
umls:C0042749 | Viremia | 3 | BeFree |
umls:C0343752 | Acute HIV infection | 3 | BeFree |
umls:C0008354 | Cholera | 2 | BeFree |
umls:C0023418 | leukemia | 2 | BeFree |
umls:C0023492 | Leukemia, T-Cell | 2 | BeFree |
umls:C0036341 | Schizophrenia | 2 | BeFree |
umls:C0042769 | Virus Diseases | 2 | BeFree |
umls:C0206019 | HIV Encephalopathy | 2 | BeFree |
umls:C0276548 | HIV encephalitis | 2 | BeFree |
umls:C0525045 | Mood Disorders | 2 | BeFree |
umls:C0004936 | Mental disorders | 1 | BeFree |
umls:C0005695 | Bladder Neoplasm | 1 | CTD_human |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0011226 | Hepatitis D Infection | 1 | BeFree |
umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
umls:C0021400 | Influenza | 1 | BeFree |
umls:C0022638 | Ketosis | 1 | BeFree |
umls:C0024302 | Reticulosarcoma | 1 | BeFree |
umls:C0024530 | Malaria | 1 | BeFree |
umls:C0027819 | Neuroblastoma | 1 | BeFree,GAD |
umls:C0038826 | Superinfection | 1 | BeFree |
umls:C0039614 | Tetanus | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0042109 | Urticaria | 1 | BeFree |
umls:C0221232 | Welts | 1 | BeFree |
umls:C0235031 | Neurologic Symptoms | 1 | BeFree |
umls:C0242723 | Parasitemia | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0343751 | Asymptomatic human immunodeficiency virus infection | 1 | BeFree |
umls:C0349637 | Common acute lymphoblastic leukemia | 1 | BeFree |
umls:C0476254 | Dyslexia | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |
umls:C0948192 | Primary infection NOS | 1 | BeFree |
umls:C1142553 | Primary HIV infection | 1 | BeFree |
umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree |