TissGeneSummary for CNBD2 |
Gene summary |
Basic gene information | Gene symbol | CNBD2 |
Gene name | cyclic nucleotide binding domain containing 2 | |
Synonyms | C20orf152|CNMPD1|dJ954P9.1 | |
Cytomap | UCSC genome browser: 20q11.23 | |
Type of gene | protein-coding | |
RefGenes | NM_001207076.1, NM_080834.2, | |
Description | cyclic nucleotide (cNMP) binding domain containing 1cyclic nucleotide-binding domain-containing protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000149646 | ||
HPRD : 09838 | ||
Vega : OTTHUMG00000032371 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CNBD2 | |
BioGPS: 140894 | ||
Pathway | NCI Pathway Interaction Database: CNBD2 | |
KEGG: CNBD2 | ||
REACTOME: CNBD2 | ||
Pathway Commons: CNBD2 | ||
Context | iHOP: CNBD2 | |
ligand binding site mutation search in PubMed: CNBD2 | ||
UCL Cancer Institute: CNBD2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CNBD2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CNBD2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CNBD2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CNBD2 |
TissGeneSNV for CNBD2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G138V | LUAD | 1 |
p.G286S | PAAD | 1 |
p.R31G | SKCM | 1 |
p.H56Y | STAD | 1 |
p.G446E | SKCM | 1 |
p.M75I | SKCM | 1 |
p.E101D | ESCA | 1 |
p.I543V | STAD | 1 |
p.D479H | THCA | 1 |
p.K483M | STAD | 1 |
p.E333K | HNSC | 1 |
p.R234W | SKCM | 1 |
p.E209K | SKCM | 1 |
p.R292W | THYM | 1 |
p.G42E | BLCA | 1 |
p.R544C | SKCM | 1 |
p.S301F | SKCM | 1 |
p.D249N | BLCA | 1 |
p.P527L | ACC | 1 |
p.R451W | HNSC | 1 |
p.Y554H | LGG | 1 |
p.K565R | SKCM | 1 |
p.P523L | ACC | 1 |
p.K229M | LUAD | 1 |
p.E236K | HNSC | 1 |
p.P327S | SARC | 1 |
p.M439I | SKCM | 1 |
p.R438Q | SKCM | 1 |
p.G360R | SKCM | 1 |
p.P176S | SKCM | 1 |
p.K561R | SKCM | 1 |
p.E262Q | CESC | 1 |
p.L193M | BLCA | 1 |
p.D483H | THCA | 1 |
p.D224N | CESC | 1 |
p.V107I | LIHC | 1 |
p.M205I | SKCM | 1 |
p.S248F | SKCM | 1 |
p.C108S | CHOL | 1 |
p.D224E | LUAD | 1 |
p.396_396insN | ESCA | 1 |
p.E333K | SKCM | 1 |
p.E167A | STAD | 1 |
p.L358P | SKCM | 1 |
p.I270M | LUAD | 1 |
p.Y550H | LGG | 1 |
p.P375L | SARC | 1 |
p.M1I | ESCA | 1 |
p.R133C | ESCA | 1 |
p.395_395insI | SKCM | 1 |
p.I91M | LUAD | 1 |
p.W494* | SKCM | 1 |
p.M443I | SKCM | 1 |
p.T208M | PAAD | 1 |
p.R37C | BLCA | 1 |
p.E418Q | CESC | 1 |
p.403_403insP | SKCM | 1 |
p.396_396insN | LIHC | 1 |
p.R234W | STAD | 1 |
p.Q487H | STAD | 1 |
p.K332R | HNSC | 1 |
p.D273H | HNSC | 1 |
p.R69Q | STAD | 1 |
p.G442E | SKCM | 1 |
p.I441F | HNSC | 1 |
p.W490X | SKCM | 1 |
p.P86T | LUAD | 1 |
p.D432N | STAD | 1 |
p.E103Q | BLCA | 1 |
p.P176L | SKCM | 1 |
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TissGeneCNV for CNBD2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CNBD2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CNBD2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CNBD2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CNBD2 |
TissGeneDrug for CNBD2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CNBD2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |