TissGeneSummary for PPP1R36 |
Gene summary |
Basic gene information | Gene symbol | PPP1R36 |
Gene name | protein phosphatase 1, regulatory subunit 36 | |
Synonyms | C14orf50 | |
Cytomap | UCSC genome browser: 14q23.3 | |
Type of gene | protein-coding | |
RefGenes | NM_172365.1, | |
Description | protein phosphatase 1 regulatory subunit 36 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000165807 | ||
HPRD : 08505 | ||
Vega : OTTHUMG00000141316 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PPP1R36 | |
BioGPS: 145376 | ||
Pathway | NCI Pathway Interaction Database: PPP1R36 | |
KEGG: PPP1R36 | ||
REACTOME: PPP1R36 | ||
Pathway Commons: PPP1R36 | ||
Context | iHOP: PPP1R36 | |
ligand binding site mutation search in PubMed: PPP1R36 | ||
UCL Cancer Institute: PPP1R36 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | PancreasTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAADTGCT | |
Reference showing the relevant tissue of PPP1R36 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0010923 | negative regulation of phosphatase activity | 19389623 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
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TissGeneExp for PPP1R36 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PPP1R36 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PPP1R36 |
TissGeneSNV for PPP1R36 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G264R | DLBC | 1 |
p.F235L | UCEC | 1 |
p.H378Y | BLCA | 1 |
p.F293S | STAD | 1 |
p.E262Q | BLCA | 1 |
p.L380F | SKCM | 1 |
p.D150E | THYM | 1 |
p.P315L | LUSC | 1 |
p.E194Q | BLCA | 1 |
p.P382S | SKCM | 1 |
p.M291I | TGCT | 1 |
p.H417N | BLCA | 1 |
p.P173L | SARC | 1 |
p.R3W | DLBC | 1 |
p.G264E | SKCM | 1 |
p.S415A | UCEC | 1 |
p.R110Q | SKCM | 1 |
p.N146S | READ | 1 |
p.S51F | SKCM | 1 |
p.R252Q | COAD | 1 |
p.Y176S | SKCM | 1 |
p.F239V | BLCA | 1 |
p.E258G | STAD | 1 |
p.V339L | LUAD | 1 |
p.T319I | LIHC | 1 |
p.S394Y | BLCA | 1 |
p.P421T | LUSC | 1 |
p.G352R | SKCM | 1 |
p.I364V | STAD | 1 |
p.K289R | LIHC | 1 |
p.R110X | COAD | 1 |
p.E185V | BLCA | 1 |
p.R278M | DLBC | 1 |
p.S388L | SKCM | 1 |
p.D93E | KIRP | 1 |
p.V124I | LGG | 1 |
p.G286V | THYM | 1 |
p.S88* | BLCA | 1 |
p.G30W | ESCA | 1 |
p.A87V | BLCA | 1 |
p.E70K | SKCM | 1 |
p.R279L | LUAD | 1 |
p.R313C | ESCA | 1 |
p.Y245D | LIHC | 1 |
p.L118Q | LUAD | 1 |
p.Y199* | UCEC | 1 |
p.H417Y | BLCA | 1 |
p.E187G | SKCM | 1 |
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TissGeneCNV for PPP1R36 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PPP1R36 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-5494-01A | ZBTB1-PPP1R36 | 5'UTR-CDS | chr14:64971664 | chr14:65031468 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A0J4-01A | ZBTB1-PPP1R36 | 5'UTR-CDS | chr14:64971664 | chr14:65031468 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-EW-A1P1-01A | ZBTB1-PPP1R36 | 5'UTR-CDS | chr14:64971664 | chr14:65031468 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-Q9-A6FW-01A | ZBTB1-PPP1R36 | 5'UTR-CDS | chr14:64971664 | chr14:65031468 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-JY-A93D-01A | ZBTB1-PPP1R36 | 5'UTR-CDS | chr14:64971664 | chr14:65053911 |
Chimerdb3.0 | FusionScan | LUSC | TCGA-39-5024-01A | ZBTB1-PPP1R36 | 5'UTR-CDS | chr14:64971664 | chr14:65031468 |
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TissGeneNet for PPP1R36 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PPP1R36 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PPP1R36 |
TissGeneDrug for PPP1R36 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PPP1R36 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |