TissGeneSummary for TMCO5A |
Gene summary |
Basic gene information | Gene symbol | TMCO5A |
Gene name | transmembrane and coiled-coil domains 5A | |
Synonyms | TMCO5 | |
Cytomap | UCSC genome browser: 15q14 | |
Type of gene | protein-coding | |
RefGenes | NM_152453.2, | |
Description | transmembrane and coiled-coil domain-containing protein 5Atransmembrane and coiled-coil domains 5 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000166069 | ||
HPRD : 11341 | ||
Vega : OTTHUMG00000129787 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TMCO5A | |
BioGPS: 145942 | ||
Pathway | NCI Pathway Interaction Database: TMCO5A | |
KEGG: TMCO5A | ||
REACTOME: TMCO5A | ||
Pathway Commons: TMCO5A | ||
Context | iHOP: TMCO5A | |
ligand binding site mutation search in PubMed: TMCO5A | ||
UCL Cancer Institute: TMCO5A | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TMCO5A | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TMCO5A |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TMCO5A |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TMCO5A |
TissGeneSNV for TMCO5A |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E83K | SKCM | 2 |
p.E172K | SKCM | 2 |
p.E202* | UCEC | 1 |
p.E89K | SKCM | 1 |
p.K269N | HNSC | 1 |
p.P251Q | LUSC | 1 |
p.Y170C | SKCM | 1 |
p.E65K | LUAD | 1 |
p.L36I | UCEC | 1 |
p.K144M | SKCM | 1 |
p.L278R | LUAD | 1 |
p.Q79P | UCS | 1 |
p.T55M | UCEC | 1 |
p.S119N | COAD | 1 |
p.H203D | LUSC | 1 |
p.R11K | SKCM | 1 |
p.T71M | HNSC | 1 |
p.L35I | UCEC | 1 |
p.Y153C | COAD | 1 |
p.R69C | UCEC | 1 |
p.F243C | SKCM | 1 |
p.E62K | HNSC | 1 |
p.K215N | GBM | 1 |
p.G57D | CESC | 1 |
p.E143K | SKCM | 1 |
p.T266I | LAML | 1 |
p.D252G | UCEC | 1 |
p.A183V | UCEC | 1 |
p.E202K | STAD | 1 |
p.F274L | UCEC | 1 |
p.R56Q | STAD | 1 |
p.I13T | SKCM | 1 |
p.E2K | SKCM | 1 |
p.P121S | SKCM | 1 |
p.T24M | GBM | 1 |
p.V246L | LUAD | 1 |
p.E42K | SKCM | 1 |
p.F234V | UCEC | 1 |
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TissGeneCNV for TMCO5A |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TMCO5A |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-05-4427-01A | SPRED1-TMCO5A | CDS-5UTR | Chr15:38545418 | Chr15:38227458 |
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TissGeneNet for TMCO5A |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TMCO5A |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TMCO5A |
TissGeneDrug for TMCO5A |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TMCO5A |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0005586 | Bipolar Disorder | 1 | GAD |
umls:C0007282 | Carotid Stenosis | 1 | GAD |