 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for SPATA8 |
 Gene summary |
| Basic gene information | Gene symbol | SPATA8 |
| Gene name | spermatogenesis associated 8 | |
| Synonyms | SRG8 | |
| Cytomap | UCSC genome browser: 15q26.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_173499.3, | |
| Description | spermatogenesis-associated protein 8spermatogenesis-related protein 8 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 613948 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000185594 | ||
| HPRD : 15432 | ||
| Vega : OTTHUMG00000149847 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SPATA8 | |
| BioGPS: 145946 | ||
| Pathway | NCI Pathway Interaction Database: SPATA8 | |
| KEGG: SPATA8 | ||
| REACTOME: SPATA8 | ||
| Pathway Commons: SPATA8 | ||
| Context | iHOP: SPATA8 | |
| ligand binding site mutation search in PubMed: SPATA8 | ||
| UCL Cancer Institute: SPATA8 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SPATA8 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for SPATA8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| Top |
| TissGene-miRNA for SPATA8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for SPATA8 |
| TissGeneSNV for SPATA8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E18K | SKCM | 6 |
| p.D33N | SKCM | 3 |
| p.E65K | SKCM | 2 |
| p.R80Q | SKCM | 2 |
| p.R4W | HNSC | 1 |
| p.E18K | HNSC | 1 |
| p.P62H | LUAD | 1 |
| p.K57N | LUSC | 1 |
| p.Q90X | SKCM | 1 |
| p.A4T | COAD | 1 |
| p.R34X | COAD | 1 |
| p.S86P | BLCA | 1 |
| p.S86F | SKCM | 1 |
| p.S22Y | LUSC | 1 |
| p.P43L | SKCM | 1 |
| p.C69R | OV | 1 |
| p.G54E | SKCM | 1 |
| p.R73K | LUSC | 1 |
| p.P43S | UCEC | 1 |
| p.P34S | SKCM | 1 |
| p.R95K | UCEC | 1 |
| p.P3L | GBM | 1 |
| p.R34Q | SKCM | 1 |
| p.P87L | SKCM | 1 |
| p.P87S | SKCM | 1 |
| p.K64N | UCEC | 1 |
| p.Q90* | SKCM | 1 |
| p.S32L | SKCM | 1 |
| p.C42F | LUAD | 1 |
| p.F36L | STAD | 1 |
| p.S32L | BLCA | 1 |
| p.A39T | SKCM | 1 |
| p.S96N | THCA | 1 |
| p.R94G | LUSC | 1 |
| p.P43L | LUAD | 1 |
| p.G19S | STAD | 1 |
| p.P29H | SKCM | 1 |
| p.P57L | SKCM | 1 |
| Top |
| TissGeneCNV for SPATA8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for SPATA8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI969380 | SPATA8-PDE3B | chr15:97328836 | chr11:14666444 | |
| Chimerdb3.0 | ChiTaRs | NA | AI651372 | SPATA8-PDE3B | chr15:97328836 | chr11:14666396 |
| Top |
| TissGeneNet for SPATA8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for SPATA8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for SPATA8 |
| TissGeneDrug for SPATA8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for SPATA8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0030567 | Parkinson Disease | 1 | GAD |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |