TissGeneSummary for TEKT5 |
Gene summary |
Basic gene information | Gene symbol | TEKT5 |
Gene name | tektin 5 | |
Synonyms | CT149 | |
Cytomap | UCSC genome browser: 16p13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_144674.1, | |
Description | tektin-5 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000153060 | ||
HPRD : 08736 | ||
Vega : OTTHUMG00000129750 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TEKT5 | |
BioGPS: 146279 | ||
Pathway | NCI Pathway Interaction Database: TEKT5 | |
KEGG: TEKT5 | ||
REACTOME: TEKT5 | ||
Pathway Commons: TEKT5 | ||
Context | iHOP: TEKT5 | |
ligand binding site mutation search in PubMed: TEKT5 | ||
UCL Cancer Institute: TEKT5 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TEKT5 | Characterization of a novel tektin member, TEKT5, in mouse sperm. J Androl. 2011 Jan-Feb;32(1):55-69. (pmid:20378928) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TEKT5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.716261395 | -1.779097602 | 1.062836207 | 2.75E-06 | 8.57E-06 |
LIHC | -0.268653257 | -1.284653257 | 1.016 | 6.70E-05 | 0.000241178 |
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TissGene-miRNA for TEKT5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TEKT5 |
TissGeneSNV for TEKT5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R82H | UCEC | 2 |
p.A59T | HNSC | 1 |
p.I456M | BLCA | 1 |
p.R103H | ESCA | 1 |
p.V27L | KIRC | 1 |
p.Q132H | HNSC | 1 |
p.S108P | LIHC | 1 |
p.R401L | THYM | 1 |
p.P91L | SKCM | 1 |
p.T373A | LIHC | 1 |
p.F150L | GBM | 1 |
p.R82C | COAD | 1 |
p.E165Q | CESC | 1 |
p.R480C | STAD | 1 |
p.D301N | SKCM | 1 |
p.R82H | SKCM | 1 |
p.R480H | LGG | 1 |
p.P74L | COAD | 1 |
p.R240_splice | GBM | 1 |
p.E254K | PAAD | 1 |
p.R472H | KIRP | 1 |
p.S290F | KIRC | 1 |
p.A341S | ACC | 1 |
p.S277R | SARC | 1 |
p.G202R | SKCM | 1 |
p.E135* | ESCA | 1 |
p.P479L | OV | 1 |
p.A370V | SKCM | 1 |
p.R197* | BLCA | 1 |
p.D464N | UCEC | 1 |
p.V206A | LIHC | 1 |
p.E453K | SKCM | 1 |
p.T272M | COAD | 1 |
p.Q134H | COAD | 1 |
p.A296G | LUSC | 1 |
p.D409N | SKCM | 1 |
p.V248M | BLCA | 1 |
p.R401H | COAD | 1 |
p.E453K | UCEC | 1 |
p.Q330K | BLCA | 1 |
p.Y36C | DLBC | 1 |
p.N417T | SKCM | 1 |
p.V206I | ESCA | 1 |
p.R88C | COAD | 1 |
p.T288M | STAD | 1 |
p.M445I | SKCM | 1 |
p.R379K | SKCM | 1 |
p.R139Q | STAD | 1 |
p.M404R | PRAD | 1 |
p.Q307E | LUAD | 1 |
p.M120I | SKCM | 1 |
p.E264* | LUSC | 1 |
p.N181K | SKCM | 1 |
p.E135D | UCEC | 1 |
p.M404I | SKCM | 1 |
p.L413M | STAD | 1 |
p.D464N | SKCM | 1 |
p.E321D | PRAD | 1 |
p.R73W | STAD | 1 |
p.H207Y | SKCM | 1 |
p.R139W | HNSC | 1 |
p.D263N | SKCM | 1 |
p.E254K | SKCM | 1 |
p.R88H | READ | 1 |
p.R103C | PRAD | 1 |
p.M375L | SKCM | 1 |
p.G5E | LUSC | 1 |
p.H452Q | SKCM | 1 |
p.E34K | SKCM | 1 |
p.L205S | BRCA | 1 |
p.N166D | HNSC | 1 |
p.R103C | STAD | 1 |
p.D464N | ESCA | 1 |
p.K430E | UCEC | 1 |
p.G136S | SKCM | 1 |
p.N181Y | SKCM | 1 |
p.S119F | SKCM | 1 |
p.A179V | GBM | 1 |
p.T171M | DLBC | 1 |
p.C275S | LGG | 1 |
p.R88H | COAD | 1 |
p.M228I | SKCM | 1 |
p.A59T | LUAD | 1 |
p.A458V | SKCM | 1 |
p.D424N | PAAD | 1 |
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TissGeneCNV for TEKT5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TEKT5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A0JL-01A | TEKT5-RMI2 | Out-of-frame | Chr16:10775850 | Chr16:11444499 |
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TissGeneNet for TEKT5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TEKT5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TEKT5 |
TissGeneDrug for TEKT5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TEKT5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0153594 | Malignant neoplasm of testis | 1 | BeFree |
umls:C0699790 | Colon Carcinoma | 1 | BeFree |