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| TissGeneSummary for NCAN |
 Gene summary |
| Basic gene information | Gene symbol | NCAN |
| Gene name | neurocan | |
| Synonyms | CSPG3 | |
| Cytomap | UCSC genome browser: 19p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004386.2, | |
| Description | chondroitin sulfate proteoglycan 3 (neurocan)neurocan core proteinneurocan proteoglycan | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600826 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000130287 | ||
| HPRD : 02897 | ||
| Vega : OTTHUMG00000182218 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NCAN | |
| BioGPS: 1463 | ||
| Pathway | NCI Pathway Interaction Database: NCAN | |
| KEGG: NCAN | ||
| REACTOME: NCAN | ||
| Pathway Commons: NCAN | ||
| Context | iHOP: NCAN | |
| ligand binding site mutation search in PubMed: NCAN | ||
| UCL Cancer Institute: NCAN | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of NCAN | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for NCAN |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -2.909471634 | -1.606940865 | -1.302530769 | 2.23E-06 | 1.16E-05 |
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| TissGene-miRNA for NCAN |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for NCAN |
| TissGeneSNV for NCAN |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E445K | SKCM | 2 |
| p.E34K | SKCM | 2 |
| p.P929S | SKCM | 2 |
| p.E396Q | SKCM | 2 |
| p.P92S | BRCA | 2 |
| p.P628S | SKCM | 2 |
| p.R1299H | UCEC | 1 |
| p.P828S | SKCM | 1 |
| p.A609D | LUSC | 1 |
| p.D776V | LUSC | 1 |
| p.Q908* | LUAD | 1 |
| p.A665T | STAD | 1 |
| p.Q862P | ACC | 1 |
| p.L684F | BLCA | 1 |
| p.D134E | LGG | 1 |
| p.K422T | STAD | 1 |
| p.G1037D | PAAD | 1 |
| p.R1282Q | SKCM | 1 |
| p.P385R | THYM | 1 |
| p.P999L | SKCM | 1 |
| p.P647T | PRAD | 1 |
| p.L1051V | LIHC | 1 |
| p.P885S | SKCM | 1 |
| p.Q1292R | STAD | 1 |
| p.P929A | SARC | 1 |
| p.E1167K | LUAD | 1 |
| p.V863L | LUSC | 1 |
| p.E986K | SKCM | 1 |
| p.E815K | SKCM | 1 |
| p.A69T | STAD | 1 |
| p.S185G | SKCM | 1 |
| p.T825A | STAD | 1 |
| p.R1119S | LUSC | 1 |
| p.S466* | UCEC | 1 |
| p.R482H | BLCA | 1 |
| p.E588Q | LUAD | 1 |
| p.E970K | SKCM | 1 |
| p.C1244G | SKCM | 1 |
| p.R480K | SKCM | 1 |
| p.T468M | PRAD | 1 |
| p.P1174L | PRAD | 1 |
| p.S831Y | BLCA | 1 |
| p.E1182K | SKCM | 1 |
| p.G128E | HNSC | 1 |
| p.L94M | LGG | 1 |
| p.G1193R | LUAD | 1 |
| p.I1256V | UCEC | 1 |
| p.D375H | STAD | 1 |
| p.L11F | THYM | 1 |
| p.Q15H | CESC | 1 |
| p.V863L | LUAD | 1 |
| p.Q1096K | LUAD | 1 |
| p.T874M | STAD | 1 |
| p.A1112V | STAD | 1 |
| p.D250N | SKCM | 1 |
| p.D151E | ESCA | 1 |
| p.P828L | SKCM | 1 |
| p.H1291Q | UCEC | 1 |
| p.R479K | SKCM | 1 |
| p.L60F | SKCM | 1 |
| p.T768I | COAD | 1 |
| p.R1117C | SKCM | 1 |
| p.W1144* | SKCM | 1 |
| p.F1138L | SKCM | 1 |
| p.D28N | SKCM | 1 |
| p.T871M | OV | 1 |
| p.D866N | BLCA | 1 |
| p.S758F | SKCM | 1 |
| p.G1040R | SKCM | 1 |
| p.P1274S | THCA | 1 |
| p.E1130K | SKCM | 1 |
| p.D791Y | LUSC | 1 |
| p.R82W | STAD | 1 |
| p.A181V | SKCM | 1 |
| p.P1218S | SKCM | 1 |
| p.R231H | OV | 1 |
| p.Y249C | PRAD | 1 |
| p.S454N | SKCM | 1 |
| p.S651F | SKCM | 1 |
| p.V884L | BRCA | 1 |
| p.T666M | SARC | 1 |
| p.D1183E | OV | 1 |
| p.I189V | HNSC | 1 |
| p.R1257* | UCEC | 1 |
| p.W1264* | SKCM | 1 |
| p.P402S | SKCM | 1 |
| p.E1222* | BLCA | 1 |
| p.A1025P | LUAD | 1 |
| p.W1264X | SKCM | 1 |
| p.G109E | SKCM | 1 |
| p.D968N | STAD | 1 |
| p.R75L | KIRC | 1 |
| p.C1052* | LUSC | 1 |
| p.G1193R | STAD | 1 |
| p.S724P | STAD | 1 |
| p.P754Q | SKCM | 1 |
| p.E1246D | STAD | 1 |
| p.G803* | LUAD | 1 |
| p.G461R | GBM | 1 |
| p.E521X | KIRC | 1 |
| p.E397K | CESC | 1 |
| p.T1085I | SKCM | 1 |
| p.R1299H | STAD | 1 |
| p.V387I | STAD | 1 |
| p.Y1102N | OV | 1 |
| p.P402T | LUAD | 1 |
| p.L636Q | LUAD | 1 |
| p.P922L | SKCM | 1 |
| p.T834M | STAD | 1 |
| p.R1257Q | BRCA | 1 |
| p.G1040R | STAD | 1 |
| p.D201G | UCEC | 1 |
| p.D367N | SKCM | 1 |
| p.D1316N | SKCM | 1 |
| p.N1066K | LUAD | 1 |
| p.E180K | SKCM | 1 |
| p.P477L | SKCM | 1 |
| p.G558D | LUAD | 1 |
| p.G1040V | LUAD | 1 |
| p.A1108V | PRAD | 1 |
| p.E981K | SKCM | 1 |
| p.T124M | MESO | 1 |
| p.P442L | HNSC | 1 |
| p.A52S | THYM | 1 |
| p.V409M | UCEC | 1 |
| p.P631H | LUAD | 1 |
| p.D1149N | STAD | 1 |
| p.N122I | LUSC | 1 |
| p.C1070F | HNSC | 1 |
| p.W984* | SKCM | 1 |
| p.N546S | LUSC | 1 |
| p.R224H | DLBC | 1 |
| p.A672D | KIRP | 1 |
| p.E1131K | SKCM | 1 |
| p.G947A | LUSC | 1 |
| p.E389V | COAD | 1 |
| p.E1113* | UVM | 1 |
| p.T907A | PAAD | 1 |
| p.P930T | PRAD | 1 |
| p.S1120F | SKCM | 1 |
| p.P562S | SKCM | 1 |
| p.H1286Q | ACC | 1 |
| p.T675I | ESCA | 1 |
| p.R217W | THYM | 1 |
| p.R193G | BLCA | 1 |
| p.R1119C | SKCM | 1 |
| p.A49S | LUAD | 1 |
| p.P574L | SKCM | 1 |
| p.C1012R | LUAD | 1 |
| p.P618S | HNSC | 1 |
| p.V677M | SKCM | 1 |
| p.E23K | SKCM | 1 |
| p.Y1234X | LIHC | 1 |
| p.S612L | CESC | 1 |
| p.A667S | HNSC | 1 |
| p.P58L | OV | 1 |
| p.E395K | SKCM | 1 |
| p.R1101C | LUSC | 1 |
| p.G326W | LUSC | 1 |
| p.P597L | LUAD | 1 |
| p.F175L | LUAD | 1 |
| p.V1152M | LGG | 1 |
| p.P433L | BLCA | 1 |
| p.F1177L | COAD | 1 |
| p.P1074S | SKCM | 1 |
| p.Y1234* | LIHC | 1 |
| p.S946* | BLCA | 1 |
| p.H646D | COAD | 1 |
| p.E641K | SKCM | 1 |
| p.T1162S | UCEC | 1 |
| p.I1145V | PAAD | 1 |
| p.G1146D | GBM | 1 |
| p.P1011S | SKCM | 1 |
| p.R1194H | COAD | 1 |
| p.E972Q | CESC | 1 |
| p.P433T | PRAD | 1 |
| p.R1090C | LUAD | 1 |
| p.G965S | SKCM | 1 |
| p.L644V | HNSC | 1 |
| p.R139C | PAAD | 1 |
| p.H360Y | BLCA | 1 |
| p.E1141Q | CESC | 1 |
| p.R1259Q | STAD | 1 |
| p.R75W | UCEC | 1 |
| p.G481E | SKCM | 1 |
| p.T174N | COAD | 1 |
| p.S920N | LUAD | 1 |
| p.P442L | SKCM | 1 |
| p.R75Q | STAD | 1 |
| p.P1011L | SKCM | 1 |
| p.G136V | LUAD | 1 |
| p.R1281Q | CESC | 1 |
| p.T666M | HNSC | 1 |
| p.F738S | SKCM | 1 |
| p.A582G | OV | 1 |
| p.G260C | STAD | 1 |
| p.R75W | LUSC | 1 |
| p.W7R | LUAD | 1 |
| p.P701R | STAD | 1 |
| p.P754L | UCEC | 1 |
| p.E591K | BLCA | 1 |
| p.R1150K | SKCM | 1 |
| p.G1216V | LUAD | 1 |
| p.R1090H | SARC | 1 |
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| TissGeneCNV for NCAN |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NCAN |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | T05316 | ZNF605-NCAN | chr12:133504973 | chr19:19360841 | |
| TCGAfusionPortal | PRADA | BLCA | TCGA-GV-A3JW-01A | RUNDC2A-NCAN | In-frame | Chr16:12121301 | Chr19:19344598 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1RG-01A | NCAN-NR2F6 | 5UTR-CDS | Chr19:19322873 | Chr19:17351574 |
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| TissGeneNet for NCAN |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| COAD (tumor) | COAD (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| KICH (tumor) | KICH (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| STAD (tumor) | STAD (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| THCA (tumor) | THCA (normal) |
| NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (tumor) | NCAN, HMGB1, PTN, TNC, CNTN2, L1CAM, TNR, NCAM1 (normal) |
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| TissGeneProg for NCAN |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NCAN |
| TissGeneDrug for NCAN |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NCAN |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0005586 | Bipolar Disorder | 7 | BeFree,GAD,GWASCAT |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 5 | BeFree |
| umls:C0036341 | Schizophrenia | 4 | BeFree |
| umls:C1263846 | Attention deficit hyperactivity disorder | 2 | BeFree |
| umls:C2711227 | Steatohepatitis | 2 | BeFree |
| umls:C0005695 | Bladder Neoplasm | 1 | CTD_human |
| umls:C0015695 | Fatty Liver | 1 | BeFree |
| umls:C0023891 | Liver Cirrhosis, Alcoholic | 1 | BeFree |
| umls:C0023896 | Alcoholic Liver Diseases | 1 | BeFree |
| umls:C0162309 | Adrenoleukodystrophy | 1 | BeFree |
| umls:C0338831 | Manic | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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