TissGeneSummary for SLC35G3 |
Gene summary |
Basic gene information | Gene symbol | SLC35G3 |
Gene name | solute carrier family 35, member G3 | |
Synonyms | AMAC1|TMEM21A | |
Cytomap | UCSC genome browser: 17q12 | |
Type of gene | protein-coding | |
RefGenes | NM_152462.2, | |
Description | acyl-malonyl condensing enzyme 1acyl-malonyl-condensing enzyme 1protein AMAC1solute carrier family 35 member G3transmembrane protein 21A | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000164729 | ||
HPRD : 12450 | ||
Vega : OTTHUMG00000132929 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC35G3 | |
BioGPS: 146861 | ||
Pathway | NCI Pathway Interaction Database: SLC35G3 | |
KEGG: SLC35G3 | ||
REACTOME: SLC35G3 | ||
Pathway Commons: SLC35G3 | ||
Context | iHOP: SLC35G3 | |
ligand binding site mutation search in PubMed: SLC35G3 | ||
UCL Cancer Institute: SLC35G3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SLC35G3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC35G3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SLC35G3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC35G3 |
TissGeneSNV for SLC35G3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L45M | KIRC | 2 |
p.A312G | HNSC | 2 |
p.R134H | UCEC | 1 |
p.T189S | STAD | 1 |
p.Y299D | READ | 1 |
p.L180I | BLCA | 1 |
p.R90H | STAD | 1 |
p.R26C | GBM | 1 |
p.Y188N | LUAD | 1 |
p.A273S | LUAD | 1 |
p.A277T | SKCM | 1 |
p.A293V | SKCM | 1 |
p.A284T | HNSC | 1 |
p.L154I | COAD | 1 |
p.Y7C | THCA | 1 |
p.G176R | SKCM | 1 |
p.P93L | SKCM | 1 |
p.R134C | GBM | 1 |
p.A312V | PAAD | 1 |
p.R103L | HNSC | 1 |
p.D92Y | HNSC | 1 |
p.C148R | STAD | 1 |
p.G334W | STAD | 1 |
p.S234F | SKCM | 1 |
p.A190P | HNSC | 1 |
p.G174* | UCEC | 1 |
p.G48D | ESCA | 1 |
p.R206W | SARC | 1 |
p.P126S | BLCA | 1 |
p.E150* | LUAD | 1 |
p.A202V | HNSC | 1 |
p.G257E | KIRC | 1 |
p.R335K | LUSC | 1 |
p.P175H | LUAD | 1 |
p.E182D | LUAD | 1 |
p.P244S | SKCM | 1 |
p.Y193* | LUAD | 1 |
p.L154P | STAD | 1 |
p.R101* | BLCA | 1 |
p.R101Q | SKCM | 1 |
p.S137Y | BLCA | 1 |
p.L149I | LUAD | 1 |
p.R26S | BLCA | 1 |
p.R103W | HNSC | 1 |
p.V245M | UCEC | 1 |
p.R59C | BLCA | 1 |
p.V194M | STAD | 1 |
p.C283Y | SKCM | 1 |
p.T179I | LGG | 1 |
p.A36T | STAD | 1 |
p.S69L | KIRC | 1 |
p.A284T | UCEC | 1 |
p.G318C | LUAD | 1 |
p.G128V | THYM | 1 |
p.A312G | PCPG | 1 |
p.V144I | COAD | 1 |
p.F106V | STAD | 1 |
p.A312G | ESCA | 1 |
p.F224I | SKCM | 1 |
p.P216L | SKCM | 1 |
p.L45M | LIHC | 1 |
p.A127T | UCEC | 1 |
p.L198M | LUAD | 1 |
p.P98A | LUAD | 1 |
p.K135N | GBM | 1 |
p.R103L | LUAD | 1 |
p.R335K | GBM | 1 |
p.L45M | TGCT | 1 |
p.G55C | PAAD | 1 |
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TissGeneCNV for SLC35G3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC35G3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC35G3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC35G3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC35G3 |
TissGeneDrug for SLC35G3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC35G3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |