TissGeneSummary for TMEM99 |
Gene summary |
Basic gene information | Gene symbol | TMEM99 |
Gene name | transmembrane protein 99 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 17q21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001195386.1, NM_001195387.1,NM_145274.3, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000167920 | ||
HPRD : 14478 | ||
Vega : OTTHUMG00000133579 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TMEM99 | |
BioGPS: 147184 | ||
Pathway | NCI Pathway Interaction Database: TMEM99 | |
KEGG: TMEM99 | ||
REACTOME: TMEM99 | ||
Pathway Commons: TMEM99 | ||
Context | iHOP: TMEM99 | |
ligand binding site mutation search in PubMed: TMEM99 | ||
UCL Cancer Institute: TMEM99 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TMEM99 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TMEM99 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 1.885972209 | 0.718850641 | 1.167121569 | 8.90E-16 | 6.19E-15 |
KICH | 0.666255582 | 1.812299582 | -1.146044 | 2.95E-07 | 1.23E-06 |
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TissGene-miRNA for TMEM99 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TMEM99 |
TissGeneSNV for TMEM99 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S105L | HNSC | 1 |
p.P98S | BLCA | 1 |
p.Q53E | LUAD | 1 |
p.N111S | DLBC | 1 |
p.H132D | BLCA | 1 |
p.W106* | LUSC | 1 |
p.S105L | PRAD | 1 |
p.K185T | UCEC | 1 |
p.H194Y | SKCM | 1 |
p.W163* | UCEC | 1 |
p.S38L | CESC | 1 |
p.S253C | BLCA | 1 |
p.L95R | COAD | 1 |
p.S75F | SKCM | 1 |
p.L91* | LGG | 1 |
p.S38L | SKCM | 1 |
p.L91X | LGG | 1 |
p.C87Y | LUAD | 1 |
p.Y79H | COAD | 1 |
p.A161G | LUAD | 1 |
p.S236F | BRCA | 1 |
p.V145I | BRCA | 1 |
p.L176V | LUSC | 1 |
p.F252L | ESCA | 1 |
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TissGeneCNV for TMEM99 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TMEM99 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A8-A092-01A | MRPL27-TMEM99 | CDS-5'UTR | chr17:48450491 | chr17:38989366 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A08L-01A | SBF2-TMEM99 | CDS-5UTR | Chr11:10215449 | Chr17:38989367 |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A26W-01A | PIP4K2B-TMEM99 | CDS-5UTR | Chr17:36933940 | Chr17:38989367 |
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TissGeneNet for TMEM99 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TMEM99 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TMEM99 |
TissGeneDrug for TMEM99 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TMEM99 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |