TissGeneSummary for CST6 |
Gene summary |
Basic gene information | Gene symbol | CST6 |
Gene name | cystatin E/M | |
Synonyms | - | |
Cytomap | UCSC genome browser: 11q13 | |
Type of gene | protein-coding | |
RefGenes | NM_001323.3, | |
Description | cystatin 6cystatin Mcystatin M/Ecystatin-6cystatin-Ecystatin-Mcysteine proteinase inhibitor | |
Modification date | 20141215 | |
dbXrefs | MIM : 601891 | |
HGNC : HGNC | ||
Ensembl : ENSG00000175315 | ||
HPRD : 03535 | ||
Vega : OTTHUMG00000166750 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CST6 | |
BioGPS: 1474 | ||
Pathway | NCI Pathway Interaction Database: CST6 | |
KEGG: CST6 | ||
REACTOME: CST6 | ||
Pathway Commons: CST6 | ||
Context | iHOP: CST6 | |
ligand binding site mutation search in PubMed: CST6 | ||
UCL Cancer Institute: CST6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of CST6 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CST6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 1.292007445 | -0.489332906 | 1.781340351 | 2.23E-12 | 9.78E-12 |
LUAD | 2.941222448 | 4.473667275 | -1.532444828 | 2.66E-06 | 8.30E-06 |
LUSC | 1.343967816 | 4.269434483 | -2.925466667 | 8.67E-17 | 6.80E-16 |
THCA | 5.918564061 | 3.63187762 | 2.286686441 | 1.49E-07 | 6.32E-07 |
KICH | -1.50826638 | 0.88896562 | -2.397232 | 9.34E-06 | 2.97E-05 |
KIRC | -1.934689047 | -0.030737658 | -1.903951389 | 4.93E-11 | 1.81E-10 |
BLCA | 3.18577762 | -0.29132238 | 3.4771 | 0.000818 | 0.006023947 |
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TissGene-miRNA for CST6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CST6 |
TissGeneSNV for CST6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G94E | SKCM | 1 |
p.K143N | UCEC | 1 |
p.R99H | READ | 1 |
p.T72M | LIHC | 1 |
p.Q136* | THCA | 1 |
p.P134S | SKCM | 1 |
p.R125C | THYM | 1 |
p.G105V | BLCA | 1 |
p.M93I | SKCM | 1 |
p.T90M | READ | 1 |
p.M91I | SKCM | 1 |
p.A83T | STAD | 1 |
p.D109N | READ | 1 |
p.M149K | STAD | 1 |
p.T90K | LIHC | 1 |
p.S4W | LUSC | 1 |
p.K100N | COAD | 1 |
p.A51V | STAD | 1 |
p.C113R | SKCM | 1 |
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TissGeneCNV for CST6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CST6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | OV | TCGA-13-1489-02A | SF1-CST6 | In-Frame | chr11:64545458 | chr11:65779656 |
Chimerdb3.0 | TopHat-Fusion | OV | TCGA-13-1489-02A | SF1-CST6 | Out-of-Frame | chr11:64545833 | chr11:65779656 |
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TissGeneNet for CST6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CST6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CST6 |
TissGeneDrug for CST6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CST6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 15 | BeFree |
umls:C0678222 | Breast Carcinoma | 14 | BeFree |
umls:C1458155 | Mammary Neoplasms | 8 | BeFree,CTD_human,LHGDN |
umls:C0027627 | Neoplasm Metastasis | 7 | BeFree |
umls:C3839957 | Hereditary cystatin C amyloid angiopathy | 4 | BeFree |
umls:C0278488 | Carcinoma breast stage IV | 3 | BeFree |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 2 | BeFree,LHGDN |
umls:C0032927 | Precancerous Conditions | 2 | BeFree |
umls:C0037274 | Dermatologic disorders | 2 | BeFree |
umls:C0239849 | Harlequin Fetus | 2 | BeFree |
umls:C0853879 | Invasive breast carcinoma | 2 | BeFree |
umls:C1512981 | Mammary Tumorigenesis | 2 | BeFree |
umls:C2936349 | Plaque, Amyloid | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
umls:C0002726 | Amyloidosis | 1 | BeFree |
umls:C0006118 | Brain Neoplasms | 1 | BeFree,LHGDN |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
umls:C0011175 | Dehydration | 1 | BeFree |
umls:C0011615 | Dermatitis, Atopic | 1 | BeFree |
umls:C0013595 | Eczema | 1 | BeFree |
umls:C0017638 | Glioma | 1 | BeFree |
umls:C0020757 | Ichthyoses | 1 | BeFree |
umls:C0020758 | Congenital ichthyosis | 1 | BeFree |
umls:C0025202 | melanoma | 1 | CTD_human |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0030297 | Pancreatic Neoplasm | 1 | LHGDN |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree,CTD_human |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0036211 | Sarcoma 180 | 1 | BeFree |
umls:C0040136 | Thyroid Neoplasm | 1 | LHGDN |
umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0206650 | Fibroadenoma | 1 | BeFree |
umls:C0220603 | childhood brain tumor | 1 | BeFree |
umls:C0238462 | Medullary carcinoma of thyroid | 1 | BeFree |
umls:C0242383 | Age related macular degeneration | 1 | BeFree |
umls:C0278601 | Inflammatory Breast Carcinoma | 1 | BeFree |
umls:C0280313 | Squamous cell carcinoma of oropharynx | 1 | BeFree |
umls:C0302592 | Cervix carcinoma | 1 | BeFree |
umls:C0346156 | Benign neoplasm of breast | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1368683 | Epithelioma | 1 | BeFree |
umls:C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | BeFree |
umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
umls:C0598226 | Harlequin type ichthyosis | 0 | MGD |