TissGeneSummary for KLC3 |
Gene summary |
Basic gene information | Gene symbol | KLC3 |
Gene name | kinesin light chain 3 | |
Synonyms | KLC2|KLC2L|KLCt|KNS2B | |
Cytomap | UCSC genome browser: 19q13 | |
Type of gene | protein-coding | |
RefGenes | NM_177417.2, NM_145275.1, | |
Description | kinesin light chain 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601334 | |
HGNC : HGNC | ||
Ensembl : ENSG00000104892 | ||
HPRD : 03212 | ||
Vega : OTTHUMG00000143722 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KLC3 | |
BioGPS: 147700 | ||
Pathway | NCI Pathway Interaction Database: KLC3 | |
KEGG: KLC3 | ||
REACTOME: KLC3 | ||
Pathway Commons: KLC3 | ||
Context | iHOP: KLC3 | |
ligand binding site mutation search in PubMed: KLC3 | ||
UCL Cancer Institute: KLC3 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Skin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCM | |
Reference showing the relevant tissue of KLC3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KLC3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 3.194832144 | 0.239312536 | 2.955519608 | 4.12E-24 | 8.07E-23 |
KIRC | -1.788833052 | 1.426223893 | -3.215056944 | 3.41E-30 | 6.53E-29 |
COAD | -0.99255677 | -3.49485677 | 2.5023 | 3.28E-10 | 4.04E-09 |
THCA | 0.977164547 | -0.676267656 | 1.653432203 | 2.70E-15 | 3.60E-14 |
KIRP | 0.51128674 | 1.739171115 | -1.227884375 | 0.000811 | 0.00229289 |
BLCA | 2.436124404 | -1.012191385 | 3.448315789 | 2.82E-05 | 0.000423762 |
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TissGene-miRNA for KLC3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KLC3 |
TissGeneSNV for KLC3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R184C | SKCM | 1 |
p.L374M | STAD | 1 |
p.R372P | BLCA | 1 |
p.R17C | UCEC | 1 |
p.R206H | COAD | 1 |
p.P159Q | LIHC | 1 |
p.K476N | BLCA | 1 |
p.E149Q | CESC | 1 |
p.R442C | GBM | 1 |
p.E113D | SARC | 1 |
p.T430I | UCEC | 1 |
p.T416I | UCEC | 1 |
p.P424S | LGG | 1 |
p.E367K | SKCM | 1 |
p.S181F | LUAD | 1 |
p.M465R | KIRC | 1 |
p.R506W | CESC | 1 |
p.V24M | DLBC | 1 |
p.Q406* | PAAD | 1 |
p.S383* | PAAD | 1 |
p.Q392X | PAAD | 1 |
p.E181K | STAD | 1 |
p.Q392* | PAAD | 1 |
p.E195K | STAD | 1 |
p.L341M | COAD | 1 |
p.Y237C | HNSC | 1 |
p.R330H | ACC | 1 |
p.T293M | UCEC | 1 |
p.L360M | STAD | 1 |
p.K144N | BRCA | 1 |
p.S397* | PAAD | 1 |
p.P182A | LUAD | 1 |
p.R316H | ACC | 1 |
p.P369H | HNSC | 1 |
p.Q481H | STAD | 1 |
p.T307M | UCEC | 1 |
p.E400X | UCS | 1 |
p.A240V | ACC | 1 |
p.R358P | BLCA | 1 |
p.E84K | COAD | 1 |
p.E414* | UCS | 1 |
p.A36V | COAD | 1 |
p.R206H | BRCA | 1 |
p.R222L | THYM | 1 |
p.S383X | PAAD | 1 |
p.E281K | SARC | 1 |
p.G60S | LIHC | 1 |
p.S150F | SKCM | 1 |
p.D420N | SKCM | 1 |
p.R492Q | STAD | 1 |
p.E409* | BLCA | 1 |
p.D351G | STAD | 1 |
p.P383H | HNSC | 1 |
p.K462N | BLCA | 1 |
p.R308L | THYM | 1 |
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TissGeneCNV for KLC3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KLC3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KLC3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KLC3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KLC3 |
TissGeneDrug for KLC3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KLC3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | GWASCAT |