TissGeneSummary for ZNF563 |
Gene summary |
Basic gene information | Gene symbol | ZNF563 |
Gene name | zinc finger protein 563 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 19p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_145276.2, | |
Description | - | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000188868 | ||
HPRD : 15845 | ||
Vega : OTTHUMG00000156413 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF563 | |
BioGPS: 147837 | ||
Pathway | NCI Pathway Interaction Database: ZNF563 | |
KEGG: ZNF563 | ||
REACTOME: ZNF563 | ||
Pathway Commons: ZNF563 | ||
Context | iHOP: ZNF563 | |
ligand binding site mutation search in PubMed: ZNF563 | ||
UCL Cancer Institute: ZNF563 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ZNF563 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ZNF563 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ZNF563 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ZNF563 |
TissGeneSNV for ZNF563 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R381Q | UCEC | 2 |
p.T373A | CESC | 2 |
p.M33V | HNSC | 1 |
p.R185* | SKCM | 1 |
p.R353X | COAD | 1 |
p.R297Q | UCEC | 1 |
p.P392S | ACC | 1 |
p.T444A | DLBC | 1 |
p.H320Y | HNSC | 1 |
p.C370S | LUAD | 1 |
p.Q55E | HNSC | 1 |
p.S180C | HNSC | 1 |
p.K396* | LUSC | 1 |
p.E132K | BLCA | 1 |
p.E49K | LUAD | 1 |
p.P349S | SKCM | 1 |
p.P98T | BLCA | 1 |
p.R213L | ESCA | 1 |
p.Y169C | THCA | 1 |
p.S95I | PRAD | 1 |
p.S231Y | UCEC | 1 |
p.E226X | COAD | 1 |
p.R335X | PAAD | 1 |
p.R298T | BLCA | 1 |
p.S295F | SKCM | 1 |
p.H387L | HNSC | 1 |
p.R437Q | UCEC | 1 |
p.E173K | ACC | 1 |
p.G361V | LUAD | 1 |
p.A429V | COAD | 1 |
p.Q145* | SKCM | 1 |
p.R181S | SARC | 1 |
p.K284T | COAD | 1 |
p.R381Q | LUAD | 1 |
p.E53X | THYM | 1 |
p.N449T | ESCA | 1 |
p.K26N | READ | 1 |
p.R217I | UCEC | 1 |
p.N183I | BLCA | 1 |
p.Y56C | BRCA | 1 |
p.E110Q | HNSC | 1 |
p.A429T | LUAD | 1 |
p.R185X | SKCM | 1 |
p.R335* | PAAD | 1 |
p.A289V | UCEC | 1 |
p.E474* | UCEC | 1 |
p.T373A | BLCA | 1 |
p.R353Q | CESC | 1 |
p.P461S | SKCM | 1 |
p.T373A | LUAD | 1 |
p.R181H | STAD | 1 |
p.I326M | STAD | 1 |
p.P235S | SKCM | 1 |
p.W18* | SKCM | 1 |
p.P23L | SKCM | 1 |
p.R213C | UCEC | 1 |
p.R357Q | UCEC | 1 |
p.R213H | LGG | 1 |
p.M67L | PRAD | 1 |
p.E100K | SKCM | 1 |
p.P349H | ESCA | 1 |
p.C255Y | UCEC | 1 |
p.I37M | BLCA | 1 |
p.R335* | BRCA | 1 |
p.S117F | SKCM | 1 |
p.H320Y | SKCM | 1 |
p.K284I | UCEC | 1 |
p.K176I | ESCA | 1 |
p.P405L | SKCM | 1 |
p.R88Q | COAD | 1 |
p.P224S | SKCM | 1 |
p.Y365H | UCEC | 1 |
p.H153R | LIHC | 1 |
p.N12S | LUSC | 1 |
p.G192C | UCEC | 1 |
p.S295Y | UCEC | 1 |
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TissGeneCNV for ZNF563 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ZNF563 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DB152946 | ZNF563-MICAL1 | chr19:12444306 | chr6:109774912 |
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TissGeneNet for ZNF563 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ZNF563 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ZNF563 |
TissGeneDrug for ZNF563 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ZNF563 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |