TissGeneSummary for ATP8B3 |
Gene summary |
Basic gene information | Gene symbol | ATP8B3 |
Gene name | ATPase, aminophospholipid transporter, class I, type 8B, member 3 | |
Synonyms | ATPIK | |
Cytomap | UCSC genome browser: 19p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001178002.2, NM_138813.3,NR_047593.2, | |
Description | ATPase, class I, type 8B, member 3aminophospholipid translocase ATP8B3phospholipid-transporting ATPase IKpotential phospholipid-transporting ATPase IKprobable phospholipid-transporting ATPase IK | |
Modification date | 20141207 | |
dbXrefs | MIM : 605866 | |
HGNC : HGNC | ||
Ensembl : ENSG00000130270 | ||
HPRD : 05793 | ||
Vega : OTTHUMG00000166189 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ATP8B3 | |
BioGPS: 148229 | ||
Pathway | NCI Pathway Interaction Database: ATP8B3 | |
KEGG: ATP8B3 | ||
REACTOME: ATP8B3 | ||
Pathway Commons: ATP8B3 | ||
Context | iHOP: ATP8B3 | |
ligand binding site mutation search in PubMed: ATP8B3 | ||
UCL Cancer Institute: ATP8B3 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ATP8B3 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ATP8B3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | 1.31381525 | -0.354217308 | 1.668032558 | 1.33E-10 | 2.67E-09 |
KIRP | 1.076015468 | -1.466712657 | 2.542728125 | 1.75E-09 | 1.57E-08 |
KIRC | 1.981480399 | -1.585462657 | 3.566943056 | 5.78E-30 | 1.09E-28 |
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TissGene-miRNA for ATP8B3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ATP8B3 |
TissGeneSNV for ATP8B3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E1241K | SKCM | 2 |
p.F521I | THYM | 1 |
p.A1092V | SKCM | 1 |
p.L166I | UCEC | 1 |
p.R478H | LGG | 1 |
p.S1017N | LGG | 1 |
p.A739V | COAD | 1 |
p.A888S | PRAD | 1 |
p.R1249C | DLBC | 1 |
p.K905R | STAD | 1 |
p.S299F | SKCM | 1 |
p.G1283R | SKCM | 1 |
p.S1247F | SKCM | 1 |
p.K1137N | PAAD | 1 |
p.E596K | SKCM | 1 |
p.E359X | COAD | 1 |
p.Q1069H | BLCA | 1 |
p.E78* | BLCA | 1 |
p.V1207M | BLCA | 1 |
p.Y1138* | BLCA | 1 |
p.R1208* | HNSC | 1 |
p.A1141T | PAAD | 1 |
p.V1209L | LIHC | 1 |
p.R342C | ESCA | 1 |
p.A1117V | PAAD | 1 |
p.K1061N | KIRP | 1 |
p.R577W | STAD | 1 |
p.S447L | SKCM | 1 |
p.G42A | THCA | 1 |
p.H1095R | STAD | 1 |
p.R199Q | STAD | 1 |
p.R693Q | GBM | 1 |
p.P746S | LUAD | 1 |
p.S1294F | SKCM | 1 |
p.G338S | ESCA | 1 |
p.A547T | PAAD | 1 |
p.V1088A | ESCA | 1 |
p.R566H | ACC | 1 |
p.N215K | ESCA | 1 |
p.E745D | COAD | 1 |
p.K1071N | KIRP | 1 |
p.D869N | SKCM | 1 |
p.P756S | LUAD | 1 |
p.L632M | LIHC | 1 |
p.A308V | BRCA | 1 |
p.T1150S | CESC | 1 |
p.V1092I | STAD | 1 |
p.V1224E | LUSC | 1 |
p.D56N | BLCA | 1 |
p.I570M | UCS | 1 |
p.E689G | LIHC | 1 |
p.G45R | COAD | 1 |
p.V1066M | STAD | 1 |
p.D884Y | UCEC | 1 |
p.N333I | UCS | 1 |
p.W565C | ESCA | 1 |
p.A1151T | PAAD | 1 |
p.Y1009H | STAD | 1 |
p.L1043I | CESC | 1 |
p.G1277S | SKCM | 1 |
p.L1270V | BRCA | 1 |
p.Y999H | STAD | 1 |
p.G1230S | SKCM | 1 |
p.V1197M | BLCA | 1 |
p.S1192R | LUAD | 1 |
p.R519C | COAD | 1 |
p.I341V | STAD | 1 |
p.Y327F | KIRP | 1 |
p.R875L | LIHC | 1 |
p.E1027D | UCS | 1 |
p.E1066K | SKCM | 1 |
p.R1112H | LUAD | 1 |
p.T303A | STAD | 1 |
p.E406* | UCEC | 1 |
p.F1212I | SKCM | 1 |
p.E290* | UCEC | 1 |
p.S184L | BLCA | 1 |
p.Y1148* | BLCA | 1 |
p.R672M | STAD | 1 |
p.G1237D | BLCA | 1 |
p.G550R | SKCM | 1 |
p.G1227D | BLCA | 1 |
p.R713H | UCEC | 1 |
p.E1037D | UCS | 1 |
p.Q502H | UCEC | 1 |
p.A1092T | SKCM | 1 |
p.F451L | BLCA | 1 |
p.R312W | HNSC | 1 |
p.G1267V | UCEC | 1 |
p.R312L | UCS | 1 |
p.R1218* | HNSC | 1 |
p.V731L | LGG | 1 |
p.L334R | BRCA | 1 |
p.A538T | HNSC | 1 |
p.K1147N | PAAD | 1 |
p.R583H | LIHC | 1 |
p.K295N | GBM | 1 |
p.R515Q | COAD | 1 |
p.E1035K | SKCM | 1 |
p.E1019K | SKCM | 1 |
p.Y532C | STAD | 1 |
p.E1082K | SKCM | 1 |
p.G1115S | SKCM | 1 |
p.R244H | ACC | 1 |
p.S856Y | STAD | 1 |
p.T305A | HNSC | 1 |
p.V527A | SKCM | 1 |
p.V348L | COAD | 1 |
p.D663H | LUAD | 1 |
p.E1073* | LUAD | 1 |
p.R196C | SKCM | 1 |
p.R340K | SKCM | 1 |
p.D176N | CESC | 1 |
p.S31T | KIRC | 1 |
p.E1226K | SKCM | 1 |
p.S755I | STAD | 1 |
p.V574A | SKCM | 1 |
p.L434V | LUSC | 1 |
p.E1222D | UCEC | 1 |
p.Q1079H | BLCA | 1 |
p.G1162S | SKCM | 1 |
p.L552P | STAD | 1 |
p.E522A | SKCM | 1 |
p.L1144V | LUAD | 1 |
p.R1102H | LUAD | 1 |
p.P594S | SKCM | 1 |
p.I1166N | SKCM | 1 |
p.R191H | ACC | 1 |
p.R519H | ACC | 1 |
p.G401S | LUAD | 1 |
p.T1140A | LIHC | 1 |
p.V1016M | COAD | 1 |
p.R114H | KIRC | 1 |
p.V1078A | ESCA | 1 |
p.E1131D | LUAD | 1 |
p.S444P | STAD | 1 |
p.K1297E | BRCA | 1 |
p.R923C | SKCM | 1 |
p.A662T | GBM | 1 |
p.R889C | LUSC | 1 |
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TissGeneCNV for ATP8B3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ATP8B3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AL048975 | ATP8B3-TFAM | chr19:1783030 | chr10:60145312 |
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TissGeneNet for ATP8B3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ATP8B3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ATP8B3 |
TissGeneDrug for ATP8B3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ATP8B3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0005586 | Bipolar Disorder | 1 | GAD |