TissGeneSummary for SLC9B1 |
Gene summary |
Basic gene information | Gene symbol | SLC9B1 |
Gene name | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | |
Synonyms | NHA1|NHEDC1 | |
Cytomap | UCSC genome browser: 4q24 | |
Type of gene | protein-coding | |
RefGenes | NM_001100874.2, NM_139173.3,NR_047513.1,NR_047515.1, | |
Description | NHE domain-containing protein 1Na(+)/H(+) exchanger-like domain-containing protein 1sodium/hydrogen exchanger 9B1sodium/hydrogen exchanger-like domain-containing protein 1solute carrier family 9, subfamily B (cation proton antiporter 2), member 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 611527 | |
HGNC : HGNC | ||
Ensembl : ENSG00000164037 | ||
HPRD : 11240 | ||
Vega : OTTHUMG00000161114 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC9B1 | |
BioGPS: 150159 | ||
Pathway | NCI Pathway Interaction Database: SLC9B1 | |
KEGG: SLC9B1 | ||
REACTOME: SLC9B1 | ||
Pathway Commons: SLC9B1 | ||
Context | iHOP: SLC9B1 | |
ligand binding site mutation search in PubMed: SLC9B1 | ||
UCL Cancer Institute: SLC9B1 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SLC9B1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC9B1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SLC9B1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC9B1 |
TissGeneSNV for SLC9B1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.C79Y | KIRC | 10 |
p.T480I | SKCM | 1 |
p.D42G | LIHC | 1 |
p.V469M | LUAD | 1 |
p.A176V | UCEC | 1 |
p.M470T | UCEC | 1 |
p.S392L | SKCM | 1 |
p.G108W | LUAD | 1 |
p.E361* | UCEC | 1 |
p.G492V | LUAD | 1 |
p.L475I | SARC | 1 |
p.A283T | LUAD | 1 |
p.P449S | SKCM | 1 |
p.E45X | COAD | 1 |
p.A188V | SKCM | 1 |
p.I477M | HNSC | 1 |
p.L295M | LUAD | 1 |
p.L270F | HNSC | 1 |
p.P231A | SARC | 1 |
p.H10Q | HNSC | 1 |
p.R61I | COAD | 1 |
p.L172P | SKCM | 1 |
p.Q23L | SKCM | 1 |
p.V228A | COAD | 1 |
p.P210S | UCEC | 1 |
p.R157T | BLCA | 1 |
p.V472A | LUAD | 1 |
p.A188T | STAD | 1 |
p.L350F | STAD | 1 |
p.L90I | UCEC | 1 |
p.I46M | STAD | 1 |
p.P118H | UCEC | 1 |
p.E453K | BLCA | 1 |
p.L478F | LUAD | 1 |
p.G190C | LUAD | 1 |
p.E513K | BLCA | 1 |
p.L486I | LUSC | 1 |
p.E457K | LUAD | 1 |
p.P210S | SKCM | 1 |
p.V76A | BLCA | 1 |
p.M80I | HNSC | 1 |
p.L123F | THYM | 1 |
p.Q366* | SKCM | 1 |
p.K208T | READ | 1 |
p.E35* | UCEC | 1 |
p.P482L | SKCM | 1 |
p.L216I | COAD | 1 |
p.E310K | BLCA | 1 |
p.H179L | LUSC | 1 |
p.I136V | UCS | 1 |
p.G333S | CESC | 1 |
p.Q366X | SKCM | 1 |
p.G385V | SKCM | 1 |
p.K37N | LUAD | 1 |
p.Q17* | SKCM | 1 |
p.D13N | SKCM | 1 |
p.Q377* | BLCA | 1 |
p.I166V | BLCA | 1 |
p.L60V | LUAD | 1 |
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TissGeneCNV for SLC9B1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC9B1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | EG327603 | SLC9B1-PTPRQ | chr4:103814571 | chr12:81067001 | |
Chimerdb3.0 | ChiTaRs | NA | AI970491 | LOC400643-SLC9B1 | chr18:6925664 | chr4:103936016 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E9-A1NA-01A | UBE2D3-SLC9B1 | 5'UTR-5'UTR | chr4:103789871 | chr4:103912869 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A1NA-01A | UBE2D3-SLC9B1 | CDS-5UTR | Chr4:103789872 | Chr4:103912869 |
TCGAfusionPortal | PRADA | LGG | TCGA-E1-5304-01A | SLC9B1-LRRK1 | Out-of-frame | Chr4:103912800 | Chr15:101586186 |
TCGAfusionPortal | PRADA | LUSC | TCGA-66-2771-01A | UBE2D3-SLC9B1 | Out-of-frame | Chr4:103789872 | Chr4:103832694 |
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TissGeneNet for SLC9B1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC9B1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC9B1 |
TissGeneDrug for SLC9B1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC9B1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010414 | Infection by Cryptococcus neoformans | 1 | BeFree |
umls:C0025309 | Meningoencephalitis | 1 | BeFree |
umls:C0026946 | Mycoses | 1 | BeFree |