TissGeneSummary for DPPA2 |
Gene summary |
Basic gene information | Gene symbol | DPPA2 |
Gene name | developmental pluripotency associated 2 | |
Synonyms | CT100|ECAT15-2|PESCRG1 | |
Cytomap | UCSC genome browser: 3q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_138815.3, | |
Description | cancer/testis antigen 100developmental pluripotency-associated protein 2embryonic stem cell (ESC) associated transcript 15-2pluripotent embryonic stem cell-related gene 1 protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 614445 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163530 | ||
HPRD : 13248 | ||
Vega : OTTHUMG00000159227 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_DPPA2 | |
BioGPS: 151871 | ||
Pathway | NCI Pathway Interaction Database: DPPA2 | |
KEGG: DPPA2 | ||
REACTOME: DPPA2 | ||
Pathway Commons: DPPA2 | ||
Context | iHOP: DPPA2 | |
ligand binding site mutation search in PubMed: DPPA2 | ||
UCL Cancer Institute: DPPA2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of DPPA2 | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for DPPA2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -1.023723114 | 0.496032886 | -1.519756 | 4.50E-09 | 2.53E-08 |
KIRC | -0.80133978 | 0.29032272 | -1.0916625 | 2.26E-15 | 1.16E-14 |
LUSC | 0.504180808 | -0.983330957 | 1.487511765 | 0.000136 | 0.000276919 |
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TissGene-miRNA for DPPA2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for DPPA2 |
TissGeneSNV for DPPA2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M40I | SKCM | 4 |
p.E17K | SKCM | 4 |
p.E117K | SKCM | 2 |
p.H244Y | SKCM | 2 |
p.D20N | SKCM | 2 |
p.R145Q | PCPG | 1 |
p.V221I | STAD | 1 |
p.S147A | BLCA | 1 |
p.R101Q | ESCA | 1 |
p.H62R | LIHC | 1 |
p.R97W | HNSC | 1 |
p.R195K | SKCM | 1 |
p.R161K | SKCM | 1 |
p.G237C | SARC | 1 |
p.S204L | SKCM | 1 |
p.R195G | HNSC | 1 |
p.E41K | SKCM | 1 |
p.E212Q | HNSC | 1 |
p.A126S | LUAD | 1 |
p.E68K | HNSC | 1 |
p.P30L | SKCM | 1 |
p.S147L | SKCM | 1 |
p.R255S | LUSC | 1 |
p.V296I | LUAD | 1 |
p.T111A | STAD | 1 |
p.R240H | LUAD | 1 |
p.D20E | HNSC | 1 |
p.H62Y | SKCM | 1 |
p.S2* | SKCM | 1 |
p.F13L | COAD | 1 |
p.K75T | SKCM | 1 |
p.R150C | STAD | 1 |
p.L63I | STAD | 1 |
p.R101Q | HNSC | 1 |
p.K32E | READ | 1 |
p.K94N | GBM | 1 |
p.C78* | LUSC | 1 |
p.A193T | BRCA | 1 |
p.A72T | SKCM | 1 |
p.D102G | HNSC | 1 |
p.V239A | STAD | 1 |
p.S270F | SKCM | 1 |
p.K94M | LUAD | 1 |
p.Y163C | HNSC | 1 |
p.V221I | HNSC | 1 |
p.R97G | SKCM | 1 |
p.R240G | HNSC | 1 |
p.V221I | COAD | 1 |
p.A201D | BLCA | 1 |
p.L231F | SKCM | 1 |
p.E38K | LUSC | 1 |
p.R168* | ACC | 1 |
p.H125Y | ESCA | 1 |
p.Q106H | SARC | 1 |
p.M257I | SKCM | 1 |
p.G61C | COAD | 1 |
p.R124M | STAD | 1 |
p.F13L | READ | 1 |
p.P84L | SKCM | 1 |
p.E68K | SKCM | 1 |
p.E38V | SKCM | 1 |
p.L293I | SKCM | 1 |
p.S232L | HNSC | 1 |
p.R101L | HNSC | 1 |
p.P271L | LGG | 1 |
p.V225L | LUSC | 1 |
p.S206F | SKCM | 1 |
p.K200N | PAAD | 1 |
p.T179N | LGG | 1 |
p.S270Y | HNSC | 1 |
p.M137T | COAD | 1 |
p.I92V | UCEC | 1 |
p.S188* | LUSC | 1 |
p.R145Q | PRAD | 1 |
p.E38K | HNSC | 1 |
p.S219F | GBM | 1 |
p.M165I | SKCM | 1 |
p.E53K | BLCA | 1 |
p.P81L | LUSC | 1 |
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TissGeneCNV for DPPA2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for DPPA2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for DPPA2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for DPPA2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for DPPA2 |
TissGeneDrug for DPPA2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for DPPA2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C1527249 | Colorectal Cancer | 2 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0027654 | Embryonal Neoplasm | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |