TissGeneSummary for FAM81B |
Gene summary |
Basic gene information | Gene symbol | FAM81B |
Gene name | family with sequence similarity 81, member B | |
Synonyms | - | |
Cytomap | UCSC genome browser: 5q15 | |
Type of gene | protein-coding | |
RefGenes | NM_152548.2, | |
Description | protein FAM81B | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000153347 | ||
HPRD : 08686 | ||
Vega : OTTHUMG00000162837 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM81B | |
BioGPS: 153643 | ||
Pathway | NCI Pathway Interaction Database: FAM81B | |
KEGG: FAM81B | ||
REACTOME: FAM81B | ||
Pathway Commons: FAM81B | ||
Context | iHOP: FAM81B | |
ligand binding site mutation search in PubMed: FAM81B | ||
UCL Cancer Institute: FAM81B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM81B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM81B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -3.12408029 | 1.41620371 | -4.540284 | 5.39E-24 | 9.63E-22 |
LUAD | 1.133761158 | 3.004459434 | -1.870698276 | 9.11E-06 | 2.68E-05 |
THCA | 0.419563642 | 1.700473811 | -1.280910169 | 3.95E-10 | 2.42E-09 |
LUSC | -1.346460918 | 2.816470455 | -4.162931373 | 1.25E-18 | 1.22E-17 |
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TissGene-miRNA for FAM81B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM81B |
TissGeneSNV for FAM81B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E352Q | KIRC | 1 |
p.R289C | BLCA | 1 |
p.R150Q | ESCA | 1 |
p.M380T | BRCA | 1 |
p.P81S | SKCM | 1 |
p.L322I | UCEC | 1 |
p.R123C | STAD | 1 |
p.S41L | CESC | 1 |
p.M428I | OV | 1 |
p.S154T | GBM | 1 |
p.A49S | SARC | 1 |
p.E57K | BLCA | 1 |
p.E201K | UCEC | 1 |
p.E13K | SKCM | 1 |
p.E152K | SKCM | 1 |
p.S154L | PRAD | 1 |
p.Q144H | COAD | 1 |
p.E381Q | COAD | 1 |
p.E318D | UCEC | 1 |
p.G330S | SKCM | 1 |
p.F410C | UCEC | 1 |
p.R150Q | SKCM | 1 |
p.A251T | STAD | 1 |
p.Q368E | LUAD | 1 |
p.R289H | BRCA | 1 |
p.R216I | ACC | 1 |
p.R150X | READ | 1 |
p.A156S | LIHC | 1 |
p.V171I | GBM | 1 |
p.Q285X | ACC | 1 |
p.R444C | COAD | 1 |
p.Q246E | BLCA | 1 |
p.N31K | BLCA | 1 |
p.I125V | BRCA | 1 |
p.R157M | UCEC | 1 |
p.D260N | DLBC | 1 |
p.S154L | UCEC | 1 |
p.M350T | UCEC | 1 |
p.E308K | PRAD | 1 |
p.K98M | STAD | 1 |
p.G148S | LIHC | 1 |
p.R289H | COAD | 1 |
p.Q73E | SARC | 1 |
p.E389K | SKCM | 1 |
p.C142W | STAD | 1 |
p.K342T | COAD | 1 |
p.M292I | SKCM | 1 |
p.E308K | STAD | 1 |
p.G268R | SKCM | 1 |
p.N203S | SKCM | 1 |
p.Q165R | SKCM | 1 |
p.A36E | LUAD | 1 |
p.A156T | GBM | 1 |
p.K151E | STAD | 1 |
p.E291K | SKCM | 1 |
p.T52A | SKCM | 1 |
p.Y307* | SKCM | 1 |
p.Q285* | ACC | 1 |
p.L6F | SKCM | 1 |
p.E291K | UCEC | 1 |
p.R188* | UCEC | 1 |
p.K75N | ESCA | 1 |
p.A82V | STAD | 1 |
p.E56Q | CESC | 1 |
p.S18L | ACC | 1 |
p.Q356H | HNSC | 1 |
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TissGeneCNV for FAM81B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM81B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | GW493199 | FAM81B-MALAT1 | chr5:94759273 | chr11:65266865 | |
Chimerdb3.0 | ChiTaRs | NA | CA311866 | FAM81B-FAM81B | chr5:94786145 | chr5:94782373 | |
TCGAfusionPortal | PRADA | LUAD | TCGA-97-8547-01A | TMEM161B-FAM81B | In-frame | Chr5:87524262 | Chr5:94749651 |
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TissGeneNet for FAM81B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM81B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM81B |
TissGeneDrug for FAM81B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM81B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |