TissGeneSummary for FAM71B |
Gene summary |
Basic gene information | Gene symbol | FAM71B |
Gene name | family with sequence similarity 71, member B | |
Synonyms | - | |
Cytomap | UCSC genome browser: 5q33.3 | |
Type of gene | protein-coding | |
RefGenes | NM_130899.2, | |
Description | protein FAM71B | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000170613 | ||
HPRD : 14516 | ||
Vega : OTTHUMG00000130246 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FAM71B | |
BioGPS: 153745 | ||
Pathway | NCI Pathway Interaction Database: FAM71B | |
KEGG: FAM71B | ||
REACTOME: FAM71B | ||
Pathway Commons: FAM71B | ||
Context | iHOP: FAM71B | |
ligand binding site mutation search in PubMed: FAM71B | ||
UCL Cancer Institute: FAM71B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of FAM71B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FAM71B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for FAM71B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FAM71B |
TissGeneSNV for FAM71B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D134N | SKCM | 2 |
p.R148H | STAD | 2 |
p.A248T | SKCM | 2 |
p.H445D | CESC | 2 |
p.E169K | SKCM | 2 |
p.R447H | LGG | 1 |
p.H239Q | LUAD | 1 |
p.H133Q | LUSC | 1 |
p.A283S | LUAD | 1 |
p.A283T | PRAD | 1 |
p.A457V | STAD | 1 |
p.G322R | LUAD | 1 |
p.A204V | HNSC | 1 |
p.N335K | PRAD | 1 |
p.V86I | GBM | 1 |
p.G58E | SKCM | 1 |
p.E514K | SKCM | 1 |
p.C155F | PRAD | 1 |
p.G216R | LUAD | 1 |
p.R30* | SARC | 1 |
p.R111C | SKCM | 1 |
p.R161L | PAAD | 1 |
p.N50Y | LUSC | 1 |
p.P439L | SKCM | 1 |
p.P79H | LUAD | 1 |
p.A361V | PAAD | 1 |
p.G396R | HNSC | 1 |
p.A204E | HNSC | 1 |
p.S522Y | LUAD | 1 |
p.G73C | LUAD | 1 |
p.A204P | LUSC | 1 |
p.A204L | HNSC | 1 |
p.R447C | DLBC | 1 |
p.I336V | STAD | 1 |
p.G103S | SKCM | 1 |
p.A314V | UCEC | 1 |
p.G332A | LUSC | 1 |
p.M18I | SKCM | 1 |
p.S342R | STAD | 1 |
p.S414T | SKCM | 1 |
p.A470T | PAAD | 1 |
p.L583M | LUAD | 1 |
p.S509L | UCEC | 1 |
p.E4K | BRCA | 1 |
p.A531S | LUAD | 1 |
p.P220A | LUAD | 1 |
p.P45A | LUAD | 1 |
p.R432I | LUAD | 1 |
p.R492Q | COAD | 1 |
p.S24P | UCEC | 1 |
p.T382I | KIRP | 1 |
p.M408T | PAAD | 1 |
p.Y407X | COAD | 1 |
p.P420H | COAD | 1 |
p.V172I | LGG | 1 |
p.E508D | LUAD | 1 |
p.G450S | SKCM | 1 |
p.M25I | SKCM | 1 |
p.E339G | SKCM | 1 |
p.S253I | LUAD | 1 |
p.S228T | HNSC | 1 |
p.R111C | UCEC | 1 |
p.E430K | SKCM | 1 |
p.N475S | GBM | 1 |
p.T382N | LUSC | 1 |
p.A464V | UCS | 1 |
p.G579D | LUAD | 1 |
p.M296I | BLCA | 1 |
p.T146A | LUAD | 1 |
p.K56R | SKCM | 1 |
p.P420A | KIRP | 1 |
p.R30Q | PAAD | 1 |
p.E593Q | LUAD | 1 |
p.P220T | CHOL | 1 |
p.E180D | LUAD | 1 |
p.G413E | SKCM | 1 |
p.F165C | LUAD | 1 |
p.D192G | PAAD | 1 |
p.H446Y | SKCM | 1 |
p.G588S | HNSC | 1 |
p.A312G | LUAD | 1 |
p.H445Y | LUAD | 1 |
p.P124S | SKCM | 1 |
p.S404R | ESCA | 1 |
p.S536C | HNSC | 1 |
p.P545A | BLCA | 1 |
p.S503N | LUAD | 1 |
p.A312E | LIHC | 1 |
p.A245T | SKCM | 1 |
p.P186T | LUAD | 1 |
p.M18V | HNSC | 1 |
p.D62Y | STAD | 1 |
p.R454C | KIRC | 1 |
p.Q308H | STAD | 1 |
p.K533R | SKCM | 1 |
p.P545S | BLCA | 1 |
p.S465Y | LUAD | 1 |
p.R492Q | READ | 1 |
p.R104Q | GBM | 1 |
p.Q212H | SKCM | 1 |
p.P250L | SARC | 1 |
p.E196K | UCEC | 1 |
p.S200I | LUSC | 1 |
p.S181T | KIRP | 1 |
p.A344V | SKCM | 1 |
p.R492X | LGG | 1 |
p.R489K | SKCM | 1 |
p.P156L | SKCM | 1 |
p.M18T | COAD | 1 |
p.G243E | SKCM | 1 |
p.M69K | LUAD | 1 |
p.E354* | UCEC | 1 |
p.K56T | COAD | 1 |
p.E323G | SKCM | 1 |
p.V565L | LUSC | 1 |
p.R431I | STAD | 1 |
p.I598T | GBM | 1 |
p.R542K | SKCM | 1 |
p.R468P | LUAD | 1 |
p.R104Q | HNSC | 1 |
p.G243R | UCEC | 1 |
p.G256W | CHOL | 1 |
p.A204S | HNSC | 1 |
p.Q519K | THYM | 1 |
p.R492* | LGG | 1 |
p.L372F | LUAD | 1 |
p.Q308X | LIHC | 1 |
p.V558I | LGG | 1 |
p.T602P | PAAD | 1 |
p.A375V | STAD | 1 |
p.R264K | SKCM | 1 |
p.S587N | BRCA | 1 |
p.K434N | CESC | 1 |
p.R447G | LUSC | 1 |
p.P250S | SARC | 1 |
p.M564T | COAD | 1 |
p.A364T | READ | 1 |
p.E575D | CESC | 1 |
p.A314V | STAD | 1 |
p.L142P | PCPG | 1 |
p.T382A | LIHC | 1 |
p.A577V | PRAD | 1 |
p.V424D | LIHC | 1 |
p.S290T | BRCA | 1 |
p.G273R | SKCM | 1 |
p.A283T | KIRP | 1 |
p.P250S | SKCM | 1 |
p.S19R | LIHC | 1 |
p.R456I | LUAD | 1 |
p.A247V | SARC | 1 |
p.R141H | KIRC | 1 |
p.N475S | BLCA | 1 |
p.R411L | STAD | 1 |
p.E48Q | BLCA | 1 |
p.R30Q | LGG | 1 |
p.S337Y | LUAD | 1 |
p.G233E | SKCM | 1 |
p.E354G | BRCA | 1 |
p.A361V | GBM | 1 |
p.V86I | HNSC | 1 |
p.S404R | LUAD | 1 |
p.Q53P | UCS | 1 |
p.P545S | SKCM | 1 |
p.A543D | STAD | 1 |
p.A292E | LUSC | 1 |
p.C96F | LUAD | 1 |
p.A531D | LUAD | 1 |
p.G233A | CESC | 1 |
p.V75I | UCEC | 1 |
p.S496F | SKCM | 1 |
p.R497C | SKCM | 1 |
p.G273E | SKCM | 1 |
p.G236R | SKCM | 1 |
p.S469Y | BLCA | 1 |
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TissGeneCNV for FAM71B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FAM71B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for FAM71B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FAM71B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FAM71B |
TissGeneDrug for FAM71B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FAM71B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |