TissGeneSummary for CYLC1 |
Gene summary |
Basic gene information | Gene symbol | CYLC1 |
Gene name | cylicin, basic protein of sperm head cytoskeleton 1 | |
Synonyms | CYCL1 | |
Cytomap | UCSC genome browser: Xq21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001271680.1, NM_021118.2, | |
Description | cylicin Icylicin-1multiple-band polypeptide I | |
Modification date | 20141207 | |
dbXrefs | MIM : 300768 | |
HGNC : HGNC | ||
Ensembl : ENSG00000183035 | ||
Vega : OTTHUMG00000021922 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYLC1 | |
BioGPS: 1538 | ||
Pathway | NCI Pathway Interaction Database: CYLC1 | |
KEGG: CYLC1 | ||
REACTOME: CYLC1 | ||
Pathway Commons: CYLC1 | ||
Context | iHOP: CYLC1 | |
ligand binding site mutation search in PubMed: CYLC1 | ||
UCL Cancer Institute: CYLC1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CYLC1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for CYLC1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.424271243 | -1.565079243 | 1.140808 | 0.00205 | 0.004199071 |
Top |
TissGene-miRNA for CYLC1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for CYLC1 |
TissGeneSNV for CYLC1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E593K | SKCM | 4 |
p.P38S | SKCM | 2 |
p.S488F | SKCM | 2 |
p.D508N | SKCM | 2 |
p.L387F | LIHC | 2 |
p.P233S | SKCM | 1 |
p.L248H | ESCA | 1 |
p.S235L | SKCM | 1 |
p.T36I | UCEC | 1 |
p.S583F | LUAD | 1 |
p.N219T | STAD | 1 |
p.G464E | SKCM | 1 |
p.M629T | LGG | 1 |
p.E331Q | LUAD | 1 |
p.P99L | SKCM | 1 |
p.P614T | LUAD | 1 |
p.P631H | UCEC | 1 |
p.S295I | PAAD | 1 |
p.R266K | HNSC | 1 |
p.K502N | UCEC | 1 |
p.E523A | READ | 1 |
p.K221N | COAD | 1 |
p.P610S | SKCM | 1 |
p.K8N | STAD | 1 |
p.T216R | COAD | 1 |
p.A158S | THYM | 1 |
p.L214I | BLCA | 1 |
p.P142S | SKCM | 1 |
p.P233S | LGG | 1 |
p.K388T | STAD | 1 |
p.D223E | PAAD | 1 |
p.I237V | STAD | 1 |
p.C238F | BRCA | 1 |
p.C195F | LGG | 1 |
p.E184K | SKCM | 1 |
p.E96K | SKCM | 1 |
p.Y91* | LUAD | 1 |
p.P19S | ESCA | 1 |
p.V313F | LUAD | 1 |
p.D408Y | LUAD | 1 |
p.V437I | STAD | 1 |
p.I403S | COAD | 1 |
p.L624H | COAD | 1 |
p.T281A | BLCA | 1 |
p.D342N | SKCM | 1 |
p.S310L | COAD | 1 |
p.D508G | STAD | 1 |
p.S273* | GBM | 1 |
p.E368K | PAAD | 1 |
p.S499P | LUAD | 1 |
p.D255Y | COAD | 1 |
p.S454X | READ | 1 |
p.K620N | LGG | 1 |
p.G136A | STAD | 1 |
p.A158E | LUSC | 1 |
p.K463N | LUAD | 1 |
p.S618A | LGG | 1 |
p.S277Y | UCEC | 1 |
p.D562Y | LUAD | 1 |
p.A113E | HNSC | 1 |
p.E168K | SKCM | 1 |
p.P450T | LUAD | 1 |
p.K473Q | HNSC | 1 |
p.R385I | UCEC | 1 |
p.T108I | SKCM | 1 |
p.K364Q | SKCM | 1 |
p.S188F | UCEC | 1 |
p.S582* | ESCA | 1 |
p.S409F | HNSC | 1 |
p.K398R | LUAD | 1 |
p.Y283N | LUAD | 1 |
p.K401N | LUSC | 1 |
p.E373D | UCEC | 1 |
p.E501K | SKCM | 1 |
p.S369Y | LUAD | 1 |
p.S227A | STAD | 1 |
p.S177F | SKCM | 1 |
p.D199N | SKCM | 1 |
p.P88T | LUAD | 1 |
p.K315E | LUAD | 1 |
p.P142T | UCEC | 1 |
p.K396Q | OV | 1 |
p.H79Y | UCEC | 1 |
p.K435M | READ | 1 |
p.E336K | SKCM | 1 |
p.X652Q | COAD | 1 |
p.R64G | STAD | 1 |
p.K402T | STAD | 1 |
p.L85F | LUAD | 1 |
p.K173M | UCEC | 1 |
p.E68Q | HNSC | 1 |
p.S54L | BLCA | 1 |
p.S277Y | COAD | 1 |
p.D302E | HNSC | 1 |
p.M249T | LUSC | 1 |
p.H74N | CESC | 1 |
p.E68G | LGG | 1 |
p.S374T | UCS | 1 |
p.K649T | STAD | 1 |
p.K378N | UCEC | 1 |
p.R5S | LUAD | 1 |
p.E605Q | BRCA | 1 |
p.S239* | LUSC | 1 |
p.D508G | LIHC | 1 |
p.K63Q | UCS | 1 |
p.I538M | CESC | 1 |
p.S568* | UCEC | 1 |
p.S277Y | READ | 1 |
p.S582X | ESCA | 1 |
p.S242R | STAD | 1 |
p.K323E | LUSC | 1 |
p.T330K | LAML | 1 |
p.D199E | STAD | 1 |
p.S337C | LUSC | 1 |
p.N194H | UCEC | 1 |
p.P617L | SKCM | 1 |
p.Q146K | COAD | 1 |
p.D202Y | UCEC | 1 |
p.K378T | UCEC | 1 |
p.Y280* | LUAD | 1 |
p.P126S | SKCM | 1 |
p.S483Y | COAD | 1 |
p.K398N | SKCM | 1 |
p.498_499HS>QP | LUAD | 1 |
p.D489G | COAD | 1 |
p.H498Q | LUAD | 1 |
p.D471Y | READ | 1 |
p.N275K | COAD | 1 |
p.D309V | SKCM | 1 |
p.K556T | ESCA | 1 |
p.G452R | SKCM | 1 |
p.E613* | UCEC | 1 |
p.P614H | PAAD | 1 |
p.S144F | SKCM | 1 |
p.K475* | UCEC | 1 |
p.K112Q | UCEC | 1 |
p.K628N | UCEC | 1 |
p.S17F | SKCM | 1 |
p.D383Y | LUAD | 1 |
p.M486I | LUAD | 1 |
p.W264C | COAD | 1 |
p.N260K | ESCA | 1 |
p.P142L | SKCM | 1 |
p.M629I | LUAD | 1 |
p.K290N | UCEC | 1 |
p.S337T | UCEC | 1 |
p.V326I | SARC | 1 |
p.T484I | SKCM | 1 |
p.G252* | LIHC | 1 |
p.G252X | LIHC | 1 |
p.T211N | LUAD | 1 |
p.R101G | COAD | 1 |
p.D399H | DLBC | 1 |
p.N156K | COAD | 1 |
p.D47V | LIHC | 1 |
p.D199H | LUSC | 1 |
p.R43I | READ | 1 |
p.D346Y | STAD | 1 |
p.F405V | PAAD | 1 |
p.K117R | LIHC | 1 |
p.E571K | HNSC | 1 |
p.L110F | KIRC | 1 |
p.S615F | UCEC | 1 |
p.K274N | STAD | 1 |
p.G464V | BLCA | 1 |
p.S239L | SKCM | 1 |
p.S192X | ESCA | 1 |
p.K478N | UCEC | 1 |
p.S528F | SKCM | 1 |
p.S192P | STAD | 1 |
p.P19S | UCEC | 1 |
p.E442* | LUAD | 1 |
p.D120N | SKCM | 1 |
p.S54L | SKCM | 1 |
p.G578X | THYM | 1 |
p.K39R | LGG | 1 |
p.P634S | SKCM | 1 |
p.A94S | DLBC | 1 |
p.M486I | STAD | 1 |
p.D256Y | HNSC | 1 |
p.K83T | STAD | 1 |
p.D395E | COAD | 1 |
p.I84S | ESCA | 1 |
p.S239* | LUAD | 1 |
p.Y115H | LIHC | 1 |
p.S541L | SKCM | 1 |
p.P636T | PAAD | 1 |
p.S192* | ESCA | 1 |
p.P450L | PRAD | 1 |
p.E605* | UCEC | 1 |
p.K455Q | ESCA | 1 |
p.S118F | SKCM | 1 |
p.E491Q | LUSC | 1 |
p.S185F | SKCM | 1 |
p.S448Y | LUAD | 1 |
p.E523A | ESCA | 1 |
p.P632R | BRCA | 1 |
p.P40L | STAD | 1 |
p.K133E | READ | 1 |
p.I237V | UCEC | 1 |
p.P601S | HNSC | 1 |
p.K465N | UCEC | 1 |
p.E422K | SKCM | 1 |
p.D516N | LIHC | 1 |
p.K327R | BLCA | 1 |
p.K176I | OV | 1 |
Top |
TissGeneCNV for CYLC1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for CYLC1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for CYLC1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for CYLC1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for CYLC1 |
TissGeneDrug for CYLC1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for CYLC1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0001175 | Acquired Immunodeficiency Syndrome | 1 | GAD |
umls:C0019693 | HIV Infections | 1 | GAD |
umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
umls:C0024299 | Lymphoma | 1 | BeFree |