TissGeneSummary for CYLC2 |
Gene summary |
Basic gene information | Gene symbol | CYLC2 |
Gene name | cylicin, basic protein of sperm head cytoskeleton 2 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 9q31.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001340.3, | |
Description | cylicin IIcylicin-2multiple-band polypeptide II | |
Modification date | 20141207 | |
dbXrefs | MIM : 604035 | |
HGNC : HGNC | ||
Ensembl : ENSG00000155833 | ||
HPRD : 04945 | ||
Vega : OTTHUMG00000020396 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CYLC2 | |
BioGPS: 1539 | ||
Pathway | NCI Pathway Interaction Database: CYLC2 | |
KEGG: CYLC2 | ||
REACTOME: CYLC2 | ||
Pathway Commons: CYLC2 | ||
Context | iHOP: CYLC2 | |
ligand binding site mutation search in PubMed: CYLC2 | ||
UCL Cancer Institute: CYLC2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CYLC2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CYLC2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CYLC2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CYLC2 |
TissGeneSNV for CYLC2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G150E | SKCM | 3 |
p.R5I | UCEC | 3 |
p.E181K | SKCM | 3 |
p.G137E | SKCM | 3 |
p.S130L | SKCM | 2 |
p.E209K | SKCM | 2 |
p.S257L | SKCM | 2 |
p.D173N | SKCM | 2 |
p.E266K | SKCM | 2 |
p.W76X | SKCM | 2 |
p.W76* | SKCM | 2 |
p.E311* | UCEC | 2 |
p.D15N | SKCM | 2 |
p.P74Q | UCEC | 1 |
p.D286N | SKCM | 1 |
p.V105F | LUSC | 1 |
p.E148D | UCEC | 1 |
p.E241K | SKCM | 1 |
p.E106K | STAD | 1 |
p.K265N | STAD | 1 |
p.S202L | SKCM | 1 |
p.Q53E | BLCA | 1 |
p.D263E | KIRP | 1 |
p.K305N | UCEC | 1 |
p.E152K | SKCM | 1 |
p.E311V | SKCM | 1 |
p.E133K | SKCM | 1 |
p.K275T | STAD | 1 |
p.D250N | SKCM | 1 |
p.G118S | SKCM | 1 |
p.G247E | SKCM | 1 |
p.A168V | THYM | 1 |
p.D229N | SKCM | 1 |
p.S132* | HNSC | 1 |
p.P74Q | PRAD | 1 |
p.D192H | SKCM | 1 |
p.D188N | SKCM | 1 |
p.K265N | ESCA | 1 |
p.K336N | UCEC | 1 |
p.E177D | UCEC | 1 |
p.R71C | BLCA | 1 |
p.K274M | LGG | 1 |
p.K226T | GBM | 1 |
p.Q73H | PAAD | 1 |
p.G118D | STAD | 1 |
p.A300G | LUAD | 1 |
p.E169D | COAD | 1 |
p.P38S | SKCM | 1 |
p.S178Y | LUAD | 1 |
p.G211R | STAD | 1 |
p.D287N | BLCA | 1 |
p.G118C | BLCA | 1 |
p.D156N | LUAD | 1 |
p.G211E | SKCM | 1 |
p.K116T | LUAD | 1 |
p.E245* | LUSC | 1 |
p.K276N | THYM | 1 |
p.D263Y | GBM | 1 |
p.E233* | STAD | 1 |
p.L67F | LUAD | 1 |
p.F11C | COAD | 1 |
p.E233D | SKCM | 1 |
p.K316N | UCEC | 1 |
p.D326N | SKCM | 1 |
p.E245K | BLCA | 1 |
p.K261R | ESCA | 1 |
p.D156Y | LIHC | 1 |
p.E233K | SKCM | 1 |
p.P74T | STAD | 1 |
p.E64K | CESC | 1 |
p.K243T | STAD | 1 |
p.A236S | BRCA | 1 |
p.I114T | LUAD | 1 |
p.K218R | SARC | 1 |
p.S141L | SKCM | 1 |
p.D250N | BLCA | 1 |
p.A203S | LUSC | 1 |
p.R71C | SKCM | 1 |
p.D108N | SKCM | 1 |
p.K243N | STAD | 1 |
p.N16Y | GBM | 1 |
p.G44E | UCEC | 1 |
p.A157P | STAD | 1 |
p.E233X | STAD | 1 |
p.K271T | ESCA | 1 |
p.T104N | LUAD | 1 |
p.D281E | LUSC | 1 |
p.D287N | SKCM | 1 |
p.G183E | THYM | 1 |
p.D281N | SKCM | 1 |
p.K265N | LUAD | 1 |
p.P38L | SKCM | 1 |
p.K143E | LUAD | 1 |
p.D173Y | UCEC | 1 |
p.D299Y | LUAD | 1 |
p.D342H | LUAD | 1 |
p.V288I | CESC | 1 |
p.K191N | LIHC | 1 |
p.R48I | READ | 1 |
p.F6S | COAD | 1 |
p.K186R | HNSC | 1 |
p.D314H | ESCA | 1 |
p.P74Q | THCA | 1 |
p.A296T | STAD | 1 |
p.K100N | UCEC | 1 |
p.A304S | HNSC | 1 |
p.S2F | COAD | 1 |
p.T45I | SKCM | 1 |
p.K305N | COAD | 1 |
p.G118D | SKCM | 1 |
p.S109Y | UCEC | 1 |
p.D255E | SKCM | 1 |
p.G199D | LIHC | 1 |
p.K316N | HNSC | 1 |
p.F33L | ESCA | 1 |
p.L134* | KIRC | 1 |
p.D195N | SKCM | 1 |
p.G118V | OV | 1 |
p.D156Y | LUAD | 1 |
p.G347D | LIHC | 1 |
p.D216Y | COAD | 1 |
p.K210N | UCEC | 1 |
p.D156A | LIHC | 1 |
p.S27L | SKCM | 1 |
p.K348M | OV | 1 |
p.K341Q | READ | 1 |
p.H32Y | LUAD | 1 |
p.G144D | UCEC | 1 |
p.D192N | SKCM | 1 |
p.G137V | LUAD | 1 |
p.F33L | READ | 1 |
p.K110T | COAD | 1 |
p.D201H | HNSC | 1 |
p.G183X | COAD | 1 |
p.G183R | STAD | 1 |
p.S196L | SKCM | 1 |
p.P4T | LUAD | 1 |
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TissGeneCNV for CYLC2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CYLC2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BQ428924 | MALAT1-CYLC2 | chr11:65267535 | chr9:105767419 |
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TissGeneNet for CYLC2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CYLC2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CYLC2 |
TissGeneDrug for CYLC2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CYLC2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0002395 | Alzheimer's Disease | 1 | GAD |
umls:C0005911 | Body Weight Changes | 1 | GAD |
umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
umls:C0027404 | Narcolepsy | 1 | GAD |
umls:C0153635 | malignant neoplasm of frontal lobe | 1 | GAD |
umls:C1561535 | Creatinine finding | 1 | GAD |