TissGeneSummary for IQUB |
Gene summary |
Basic gene information | Gene symbol | IQUB |
Gene name | IQ motif and ubiquitin domain containing | |
Synonyms | - | |
Cytomap | UCSC genome browser: 7q31.32 | |
Type of gene | protein-coding | |
RefGenes | NM_001282855.1, NM_178827.4,NR_104244.1,NR_104245.1, | |
Description | IQ and ubiquitin-like domain-containing protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000164675 | ||
HPRD : 08194 | ||
Vega : OTTHUMG00000157347 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IQUB | |
BioGPS: 154865 | ||
Pathway | NCI Pathway Interaction Database: IQUB | |
KEGG: IQUB | ||
REACTOME: IQUB | ||
Pathway Commons: IQUB | ||
Context | iHOP: IQUB | |
ligand binding site mutation search in PubMed: IQUB | ||
UCL Cancer Institute: IQUB | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of IQUB | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IQUB |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.958265084 | 0.387855605 | -1.34612069 | 2.78E-06 | 8.65E-06 |
LUSC | -1.564377593 | 0.448369466 | -2.012747059 | 1.09E-11 | 4.51E-11 |
KICH | -2.607392808 | 2.421483192 | -5.028876 | 4.80E-17 | 1.82E-15 |
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TissGene-miRNA for IQUB |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IQUB |
TissGeneSNV for IQUB |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.W773* | SKCM | 2 |
p.S33* | BLCA | 1 |
p.D220H | HNSC | 1 |
p.G141A | HNSC | 1 |
p.H56Y | LUAD | 1 |
p.F752I | LIHC | 1 |
p.H335Y | KIRC | 1 |
p.V581F | HNSC | 1 |
p.P756S | SKCM | 1 |
p.D517N | SKCM | 1 |
p.R286K | LIHC | 1 |
p.V135L | BRCA | 1 |
p.E678K | SKCM | 1 |
p.T442A | STAD | 1 |
p.S55N | THCA | 1 |
p.Q535X | ACC | 1 |
p.E497X | STAD | 1 |
p.S69L | SKCM | 1 |
p.Q649E | BLCA | 1 |
p.V126M | COAD | 1 |
p.C625* | HNSC | 1 |
p.K749N | UCEC | 1 |
p.A10D | KIRP | 1 |
p.G551* | UCS | 1 |
p.N500H | UCEC | 1 |
p.W710R | ESCA | 1 |
p.D695A | BLCA | 1 |
p.S84P | UCEC | 1 |
p.L557I | UCEC | 1 |
p.E767K | SKCM | 1 |
p.K782M | HNSC | 1 |
p.K586N | HNSC | 1 |
p.K355N | BLCA | 1 |
p.G326E | LUSC | 1 |
p.C604F | STAD | 1 |
p.N702K | SKCM | 1 |
p.Q4* | SKCM | 1 |
p.S16L | SKCM | 1 |
p.C690* | LUAD | 1 |
p.V136L | LUAD | 1 |
p.T226N | LUAD | 1 |
p.S89L | HNSC | 1 |
p.V135F | LUSC | 1 |
p.K179N | BLCA | 1 |
p.L437P | STAD | 1 |
p.V263A | UCEC | 1 |
p.L547F | SKCM | 1 |
p.S777* | BLCA | 1 |
p.S685* | ESCA | 1 |
p.E80Q | DLBC | 1 |
p.E486Q | LUSC | 1 |
p.I202L | STAD | 1 |
p.T132K | BLCA | 1 |
p.A428P | KICH | 1 |
p.P92S | SKCM | 1 |
p.E536* | LUAD | 1 |
p.E120* | LUAD | 1 |
p.A720V | HNSC | 1 |
p.G232V | UCEC | 1 |
p.L520V | SKCM | 1 |
p.Q189X | KIRP | 1 |
p.S760L | SKCM | 1 |
p.D778N | SKCM | 1 |
p.V358I | UCEC | 1 |
p.L157V | LUSC | 1 |
p.E382V | LUSC | 1 |
p.D695N | SKCM | 1 |
p.S753F | SKCM | 1 |
p.V88F | OV | 1 |
p.G766C | SKCM | 1 |
p.R638Q | HNSC | 1 |
p.E719* | BRCA | 1 |
p.V88F | PRAD | 1 |
p.P32L | SKCM | 1 |
p.R621H | UCEC | 1 |
p.A10S | OV | 1 |
p.W701X | SKCM | 1 |
p.P579S | SKCM | 1 |
p.C285R | KIRC | 1 |
p.D765Y | UCEC | 1 |
p.W773X | SKCM | 1 |
p.R620C | STAD | 1 |
p.D65N | SKCM | 1 |
p.Q754H | HNSC | 1 |
p.S162L | BLCA | 1 |
p.V82I | READ | 1 |
p.R735H | ESCA | 1 |
p.P709S | HNSC | 1 |
p.S685X | ESCA | 1 |
p.W352R | LUSC | 1 |
p.S33P | UCEC | 1 |
p.V518A | STAD | 1 |
p.V241A | COAD | 1 |
p.S89L | BRCA | 1 |
p.T28N | UCEC | 1 |
p.D106N | SKCM | 1 |
p.R414Q | STAD | 1 |
p.G766D | SKCM | 1 |
p.R700* | LIHC | 1 |
p.Q787H | LUAD | 1 |
p.Q535* | ACC | 1 |
p.E124* | UCEC | 1 |
p.K327N | UCEC | 1 |
p.P139S | SKCM | 1 |
p.E19* | HNSC | 1 |
p.R626C | HNSC | 1 |
p.T288M | STAD | 1 |
p.M698I | SKCM | 1 |
p.W477* | SKCM | 1 |
p.R621C | STAD | 1 |
p.Q235H | COAD | 1 |
p.E359D | READ | 1 |
p.E770D | LUAD | 1 |
p.Q11E | COAD | 1 |
p.T288M | READ | 1 |
p.A565V | OV | 1 |
p.E497* | STAD | 1 |
p.H570R | KIRC | 1 |
p.V291I | UCEC | 1 |
p.W701* | SKCM | 1 |
p.S84L | SKCM | 1 |
p.Q4H | LUSC | 1 |
p.E536D | UCEC | 1 |
p.S129F | SKCM | 1 |
p.Q649* | OV | 1 |
p.E536D | SKCM | 1 |
p.V136L | SKCM | 1 |
p.Q77K | GBM | 1 |
p.Y407C | KIRP | 1 |
p.L218X | COAD | 1 |
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TissGeneCNV for IQUB |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IQUB |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | PRAD | TCGA-CH-5741-01A | TRIO-IQUB | In-Frame | chr5:14304701 | chr7:123097620 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A1-A0SN-01A | IQUB-ASB15 | 5UTR-5UTR | Chr7:123174546 | Chr7:123254555 |
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TissGeneNet for IQUB |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IQUB |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IQUB |
TissGeneDrug for IQUB |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IQUB |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |