TissGeneSummary for KCNU1 |
Gene summary |
Basic gene information | Gene symbol | KCNU1 |
Gene name | potassium channel, subfamily U, member 1 | |
Synonyms | KCNMC1|KCa5|KCa5.1|Kcnma3|Slo3 | |
Cytomap | UCSC genome browser: 8p11.23 | |
Type of gene | protein-coding | |
RefGenes | NM_001031836.2, | |
Description | Calcium-activated potassium channel subunit alpha-3Calcium-activated potassium channel, subfamily M subunit alpha-3Slowpoke homolog 3potassium channel subfamily U member 1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 615215 | |
HGNC : HGNC | ||
Ensembl : ENSG00000215262 | ||
Vega : OTTHUMG00000163981 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KCNU1 | |
BioGPS: 157855 | ||
Pathway | NCI Pathway Interaction Database: KCNU1 | |
KEGG: KCNU1 | ||
REACTOME: KCNU1 | ||
Pathway Commons: KCNU1 | ||
Context | iHOP: KCNU1 | |
ligand binding site mutation search in PubMed: KCNU1 | ||
UCL Cancer Institute: KCNU1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KCNU1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KCNU1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.143591377 | -1.642471377 | 1.49888 | 0.0142 | 0.024740553 |
LIHC | 0.337486623 | -1.479475377 | 1.816962 | 0.000193 | 0.000621236 |
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TissGene-miRNA for KCNU1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KCNU1 |
TissGeneSNV for KCNU1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R704Q | SKCM | 3 |
p.P868S | SKCM | 2 |
p.G85E | BLCA | 2 |
p.A788V | STAD | 2 |
p.H551D | SARC | 1 |
p.G38C | BLCA | 1 |
p.A424V | OV | 1 |
p.T564M | STAD | 1 |
p.L29F | BLCA | 1 |
p.S31F | SKCM | 1 |
p.P802S | COAD | 1 |
p.K749N | GBM | 1 |
p.Y710F | STAD | 1 |
p.L552I | LUAD | 1 |
p.S116C | GBM | 1 |
p.R202C | STAD | 1 |
p.I1105V | LUAD | 1 |
p.I261T | LGG | 1 |
p.K594N | LUAD | 1 |
p.I63N | COAD | 1 |
p.P251L | SKCM | 1 |
p.T811S | SKCM | 1 |
p.R960Q | READ | 1 |
p.A948V | LUAD | 1 |
p.F32L | LIHC | 1 |
p.V1059G | LUAD | 1 |
p.Q577K | KIRP | 1 |
p.D136H | BRCA | 1 |
p.R765Q | THYM | 1 |
p.R713W | READ | 1 |
p.P771S | SKCM | 1 |
p.P860H | STAD | 1 |
p.G491D | DLBC | 1 |
p.E265K | HNSC | 1 |
p.F993C | READ | 1 |
p.A147V | UCEC | 1 |
p.N220S | SKCM | 1 |
p.P802T | LUAD | 1 |
p.R88P | STAD | 1 |
p.A740G | HNSC | 1 |
p.G879X | ESCA | 1 |
p.P1121H | LGG | 1 |
p.R857Q | LAML | 1 |
p.M637I | SKCM | 1 |
p.A727D | LUAD | 1 |
p.W1107* | SKCM | 1 |
p.T378P | STAD | 1 |
p.L1032I | STAD | 1 |
p.L232I | UCEC | 1 |
p.S1070A | PAAD | 1 |
p.I414T | UVM | 1 |
p.R857L | BLCA | 1 |
p.S70L | STAD | 1 |
p.E363Q | CESC | 1 |
p.F482L | SKCM | 1 |
p.P207S | SKCM | 1 |
p.E477* | LUAD | 1 |
p.L738F | LUAD | 1 |
p.G878R | LUAD | 1 |
p.S783F | SKCM | 1 |
p.T1077N | STAD | 1 |
p.Q98H | BRCA | 1 |
p.I829T | LUAD | 1 |
p.G62V | READ | 1 |
p.C337* | HNSC | 1 |
p.F32S | GBM | 1 |
p.L955F | DLBC | 1 |
p.T897M | LUAD | 1 |
p.I212T | LUAD | 1 |
p.R88C | UCEC | 1 |
p.P860S | SKCM | 1 |
p.V312L | LUAD | 1 |
p.R713W | UCEC | 1 |
p.F1050L | READ | 1 |
p.E970K | UCEC | 1 |
p.S726* | LUAD | 1 |
p.Q511H | BLCA | 1 |
p.A347T | LUAD | 1 |
p.L891I | UCEC | 1 |
p.I447K | GBM | 1 |
p.E369X | CHOL | 1 |
p.G946D | LUAD | 1 |
p.P1029T | LUAD | 1 |
p.F766Y | THYM | 1 |
p.S248F | UCEC | 1 |
p.P802H | LUAD | 1 |
p.P1102S | HNSC | 1 |
p.G643X | ESCA | 1 |
p.R202H | UCEC | 1 |
p.P1075A | LUAD | 1 |
p.Q810K | LUAD | 1 |
p.F153I | LUSC | 1 |
p.S1091Y | COAD | 1 |
p.R529H | THCA | 1 |
p.S393C | LUAD | 1 |
p.S498Y | KIRP | 1 |
p.P1121S | SKCM | 1 |
p.M395I | LUAD | 1 |
p.S391P | SKCM | 1 |
p.V1017A | COAD | 1 |
p.D161Y | LUSC | 1 |
p.S908Y | UCEC | 1 |
p.R713W | COAD | 1 |
p.S435F | LIHC | 1 |
p.R7* | LAML | 1 |
p.E875K | BRCA | 1 |
p.D949N | ESCA | 1 |
p.L827F | LUAD | 1 |
p.R7Q | SKCM | 1 |
p.R544Q | STAD | 1 |
p.R202H | DLBC | 1 |
p.E1130K | BLCA | 1 |
p.Q876* | CESC | 1 |
p.D785V | BRCA | 1 |
p.Y268C | LGG | 1 |
p.F753L | UCEC | 1 |
p.E852D | UCEC | 1 |
p.R713W | LGG | 1 |
p.R354H | STAD | 1 |
p.F753S | LUAD | 1 |
p.M537I | PRAD | 1 |
p.L545I | LUAD | 1 |
p.W764C | ESCA | 1 |
p.R7Q | PRAD | 1 |
p.Q98H | THYM | 1 |
p.Q448R | HNSC | 1 |
p.R88C | SKCM | 1 |
p.G481V | THYM | 1 |
p.G879* | ESCA | 1 |
p.A239V | COAD | 1 |
p.V342L | LUAD | 1 |
p.S1087T | LUAD | 1 |
p.D679N | SKCM | 1 |
p.W768R | COAD | 1 |
p.F45S | UCEC | 1 |
p.E169K | SKCM | 1 |
p.R7* | MESO | 1 |
p.L884F | LUAD | 1 |
p.R857Q | HNSC | 1 |
p.V720L | LUAD | 1 |
p.G825R | UCEC | 1 |
p.V104M | LGG | 1 |
p.R1002Q | UCEC | 1 |
p.Q1064K | LUAD | 1 |
p.H787Y | SKCM | 1 |
p.R960W | UCEC | 1 |
p.L562P | PRAD | 1 |
p.S838L | COAD | 1 |
p.S633* | LGG | 1 |
p.L526M | COAD | 1 |
p.Q682H | STAD | 1 |
p.Y743* | LUAD | 1 |
p.L213I | UCEC | 1 |
p.N618K | COAD | 1 |
p.S662L | COAD | 1 |
p.R647L | LUAD | 1 |
p.R765G | LUAD | 1 |
p.L155W | BLCA | 1 |
p.T468N | LUAD | 1 |
p.P803T | OV | 1 |
p.E363X | THYM | 1 |
p.E864* | LUAD | 1 |
p.R88C | HNSC | 1 |
p.N416I | STAD | 1 |
p.R290W | LUAD | 1 |
p.F197L | LIHC | 1 |
p.D991Y | OV | 1 |
p.I754L | STAD | 1 |
p.P462S | THYM | 1 |
p.G903S | THCA | 1 |
p.N247T | ESCA | 1 |
p.A159S | LUAD | 1 |
p.W1107X | SKCM | 1 |
p.G299W | STAD | 1 |
p.I267M | UCS | 1 |
p.A347T | PRAD | 1 |
p.Q1119* | UCEC | 1 |
p.R402* | UCEC | 1 |
p.N733K | LUAD | 1 |
p.A718T | STAD | 1 |
p.A476P | STAD | 1 |
p.E886* | UCEC | 1 |
p.G1123R | HNSC | 1 |
p.A284V | UCEC | 1 |
p.L400V | STAD | 1 |
p.S1117L | CESC | 1 |
p.F1050L | UCEC | 1 |
p.S185F | BRCA | 1 |
p.P654L | STAD | 1 |
p.I184M | READ | 1 |
p.S795Y | LUAD | 1 |
p.T668N | BLCA | 1 |
p.E970K | SKCM | 1 |
p.A415P | ESCA | 1 |
p.T564A | UCEC | 1 |
p.P844L | SKCM | 1 |
p.V947L | LUSC | 1 |
p.D750N | KIRC | 1 |
p.P1075H | STAD | 1 |
p.S680P | STAD | 1 |
p.C1043F | LUAD | 1 |
p.T362A | LIHC | 1 |
p.F348L | SKCM | 1 |
p.F183L | LUSC | 1 |
p.D161Y | THYM | 1 |
p.F2Y | SKCM | 1 |
p.T668K | BLCA | 1 |
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TissGeneCNV for KCNU1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KCNU1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | UCEC | TCGA-K6-A3WQ-01A | PLEKHA2-KCNU1 | In-Frame | chr8:38814904 | chr8:36663786 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-BH-A0EI-01A | KCNU1-PLEKHA2 | In-Frame | chr8:36642078 | chr8:38801354 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-A2-A0EX-01A | KCNU1-CYP7B1 | Out-of-Frame | chr8:36704930 | chr8:65571309 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-A2-A0EX-01A | KCNU1-ERLIN2 | Out-of-Frame | chr8:36705089 | chr8:37603530 |
TCGAfusionPortal | PRADA | BLCA | TCGA-FT-A3EE-01A | RAB11FIP1-KCNU1 | In-frame | Chr8:37756589 | Chr8:36763226 |
TCGAfusionPortal | PRADA | BRCA | TCGA-C8-A12X-01A | PLEKHA2-KCNU1 | NA | Chr8:38759410 | Chr8:36793033 |
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TissGeneNet for KCNU1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KCNU1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KCNU1 |
TissGeneDrug for KCNU1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KCNU1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |