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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CYP7A1
check button Gene summary
Basic gene informationGene symbolCYP7A1
Gene namecytochrome P450, family 7, subfamily A, polypeptide 1
SynonymsCP7A|CYP7|CYPVII
CytomapUCSC genome browser: 8q11-q12
Type of geneprotein-coding
RefGenesNM_000780.3,
Descriptioncholesterol 7-alpha-hydroxylasecholesterol 7-alpha-monooxygenasecytochrome P450 7A1cytochrome P450, subfamily VIIA polypeptide 1
Modification date20141222
dbXrefs MIM : 118455
HGNC : HGNC
Ensembl : ENSG00000167910
HPRD : 00324
Vega : OTTHUMG00000164301
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CYP7A1
BioGPS: 1581
PathwayNCI Pathway Interaction Database: CYP7A1
KEGG: CYP7A1
REACTOME: CYP7A1
Pathway Commons: CYP7A1
ContextiHOP: CYP7A1
ligand binding site mutation search in PubMed: CYP7A1
UCL Cancer Institute: CYP7A1
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of CYP7A1Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease. Lemberger UJ, Fuchs CD, Karer M, Haas S, Stojakovic T, Schöfer C, Marschall HU, Wrba F, Taketo MM, Egger G, Trauner M, Österreicher CH. Oncotarget. 2016 Dec 27;7(52):86985-86998. doi: 10.18632/oncotarget.13521. (pmid:27895309)
go to article
Description by TissGene annotationsTissgsKTS
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006699bile acid biosynthetic process19965590
GO:0070857regulation of bile acid biosynthetic process19965590
GO:0071333cellular response to glucose stimulus19965590
GO:0006699bile acid biosynthetic process19965590
GO:0070857regulation of bile acid biosynthetic process19965590
GO:0071333cellular response to glucose stimulus19965590


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TissGeneExp for CYP7A1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KICH-2.23983452-1.08965452-1.150188.70E-116.78E-10
BRCA-1.995067959-0.79875217-1.1963157892.75E-344.96E-33


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TissGene-miRNA for CYP7A1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CYP7A1
TissGeneSNV for CYP7A1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.D213NUCEC2
p.P40TCESC1
p.R177LCOAD1
p.H136QSKCM1
p.H244QTHYM1
p.L486FLGG1
p.M72TPRAD1
p.R61SSTAD1
p.T419APAAD1
p.P82LSKCM1
p.L42MLUSC1
p.R250KSKCM1
p.S173YUCEC1
p.S173YUCS1
p.R112IUCEC1
p.L267*SKCM1
p.T419RCESC1
p.K475EUCEC1
p.H395QTHYM1
p.D96YBLCA1
p.D272YBLCA1
p.R195WGBM1
p.A231VCOAD1
p.D213NSTAD1
p.S286LUCEC1
p.P436SSKCM1
p.R382QHNSC1
p.K93*LUSC1
p.P155LUCEC1
p.G440RSKCM1
p.A234DHNSC1
p.W166CLUSC1
p.C69YCOAD1
p.L42PLUSC1
p.G119*LUAD1
p.S286LLUAD1
p.I459FLUAD1
p.N233SCOAD1
p.P404SBLCA1
p.S463CBLCA1
p.I470LLUSC1
p.F100IHNSC1
p.E236KSKCM1
p.K87MLUSC1
p.Q198RLUAD1
p.T163IHNSC1
p.D213NBLCA1
p.D403NSTAD1
p.D384HBLCA1
p.G49SUCEC1
p.P445TLUAD1
p.H232NLGG1
p.S353LCOAD1
p.H77NUCEC1
p.H395NLUAD1
p.D494YCOAD1
p.V76ISTAD1
p.L22PSTAD1
p.A288SCOAD1
p.Y85*LUAD1
p.R195LKIRP1
p.R260LCOAD1
p.A366VSKCM1
p.P52SSKCM1
p.S258RBLCA1
p.G377ASKCM1
p.A164THNSC1
p.E453KSKCM1
p.A231TTHYM1
p.L467FOV1
p.P332AHNSC1
p.R260CLIHC1
p.L346FBRCA1
p.A45SBRCA1
p.E236DBLCA1
p.V281MCOAD1
p.L267XSKCM1
p.M435VUCEC1
p.A484TSTAD1
p.L340MLUAD1
p.R151CCOAD1
p.D494NUCEC1
p.A474PPAAD1
p.I114MSTAD1
p.S268FBLCA1


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TissGeneCNV for CYP7A1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CYP7A1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for CYP7A1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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COAD (tumor)COAD (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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HNSC (tumor)HNSC (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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KICH (tumor)KICH (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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KIRC (tumor)KIRC (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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KIRP (tumor)KIRP (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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LIHC (tumor)LIHC (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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LUAD (tumor)LUAD (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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LUSC (tumor)LUSC (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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PRAD (tumor)PRAD (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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STAD (tumor)STAD (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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THCA (tumor)THCA (normal)
CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (tumor)CYP7A1, NR1H3, NR5A2, HNF1A, NR2F2 (normal)
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TissGeneProg for CYP7A1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CYP7A1
TissGeneDrug for CYP7A1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CYP7A1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0008350Cholelithiasis6BeFree,GAD
umls:C0020443Hypercholesterolemia6BeFree,CTD_human,GAD
umls:C2239176Liver carcinoma6BeFree,LHGDN
umls:C0008370Cholestasis5BeFree,CTD_human
umls:C0947622Cholecystolithiasis5BeFree,GAD
umls:C1956346Coronary Artery Disease5BeFree,GAD
umls:C0007222Cardiovascular Diseases4BeFree,GAD
umls:C0010054Coronary Arteriosclerosis4BeFree,GAD
umls:C0023903Liver neoplasms4BeFree
umls:C0008312Primary biliary cirrhosis3BeFree
umls:C0020445Hypercholesterolemia, Familial3BeFree
umls:C0020473Hyperlipidemia3BeFree,GAD,LHGDN
umls:C0856727Cholesterol gallstones3BeFree
umls:C1527249Colorectal Cancer3BeFree,GAD
umls:C0005684Malignant neoplasm of urinary bladder2GAD
umls:C0007102Malignant tumor of colon2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0010068Coronary heart disease2BeFree
umls:C0011847Diabetes2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0020557Hypertriglyceridemia2GAD
umls:C0027051Myocardial Infarction2GAD
umls:C0027873Neuromyelitis Optica2BeFree,GAD
umls:C0028754Obesity2BeFree,GAD
umls:C0153452Malignant neoplasm of gallbladder2BeFree
umls:C0235782Gallbladder Carcinoma2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C0699790Colon Carcinoma2BeFree
umls:C1302401Adenoma of large intestine2BeFree
umls:C1522137Hypertriglyceridemia result2GAD
umls:C0000786Spontaneous abortion1GAD
umls:C0003850Arteriosclerosis1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0004352Autistic Disorder1GAD
umls:C0007273Carotid Artery Diseases1GAD
umls:C0016978gallbladder neoplasm1LHGDN
umls:C0020474Hyperlipidemia, Familial Combined1BeFree
umls:C0020479Hyperlipoproteinemia Type III1GAD
umls:C0020538Hypertensive disease1BeFree
umls:C0020550Hyperthyroidism1BeFree
umls:C0023895Liver diseases1BeFree
umls:C0025517Metabolic Diseases1BeFree
umls:C0040053Thrombosis1GAD
umls:C0041296Tuberculosis1BeFree
umls:C0042755Virilism1GAD
umls:C0085215Ovarian Failure, Premature1BeFree
umls:C0242216Biliary calculi1LHGDN
umls:C0518010body mass1GAD
umls:C0796126AICARDI-GOUTIERES SYNDROME 11BeFree
umls:C0860204Cholestatic liver disease1BeFree
umls:C1271104Blood pressure finding1GAD
umls:C1272641Systemic arterial pressure1GAD