TissGeneSummary for CCDC67 |
Gene summary |
Basic gene information | Gene symbol | CCDC67 |
Gene name | coiled-coil domain containing 67 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 11q21 | |
Type of gene | protein-coding | |
RefGenes | NM_181645.3, | |
Description | coiled-coil domain-containing protein 67deuterosome protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000165325 | ||
HPRD : 08689 | ||
Vega : OTTHUMG00000167441 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC67 | |
BioGPS: 159989 | ||
Pathway | NCI Pathway Interaction Database: CCDC67 | |
KEGG: CCDC67 | ||
REACTOME: CCDC67 | ||
Pathway Commons: CCDC67 | ||
Context | iHOP: CCDC67 | |
ligand binding site mutation search in PubMed: CCDC67 | ||
UCL Cancer Institute: CCDC67 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CCDC67 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC67 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.791548169 | 0.817114543 | -1.608662712 | 1.75E-14 | 2.04E-13 |
KICH | -2.669404915 | -0.315264915 | -2.35414 | 6.61E-15 | 1.32E-13 |
KIRP | -2.10795479 | -0.431164165 | -1.676790625 | 2.10E-07 | 1.21E-06 |
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TissGene-miRNA for CCDC67 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC67 |
TissGeneSNV for CCDC67 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R72* | UCEC | 2 |
p.E381K | SKCM | 2 |
p.D35N | SKCM | 2 |
p.G308E | SARC | 1 |
p.K407T | COAD | 1 |
p.Q171* | THCA | 1 |
p.V502L | UCEC | 1 |
p.T424I | SKCM | 1 |
p.M40L | SKCM | 1 |
p.L394M | LUAD | 1 |
p.R295K | SKCM | 1 |
p.Q117R | SARC | 1 |
p.R46* | HNSC | 1 |
p.R46* | ACC | 1 |
p.L436V | UCEC | 1 |
p.Q161* | SKCM | 1 |
p.Q94R | LUAD | 1 |
p.H511Y | SKCM | 1 |
p.E330* | UCEC | 1 |
p.R46X | ACC | 1 |
p.R46Q | SKCM | 1 |
p.G478R | SKCM | 1 |
p.M400I | SKCM | 1 |
p.C303F | ESCA | 1 |
p.E53K | SKCM | 1 |
p.L563F | SKCM | 1 |
p.V100L | KIRP | 1 |
p.M34I | HNSC | 1 |
p.E364K | SKCM | 1 |
p.V502A | DLBC | 1 |
p.I25V | STAD | 1 |
p.K599N | STAD | 1 |
p.G301A | LUAD | 1 |
p.R46X | PAAD | 1 |
p.Q141H | COAD | 1 |
p.K243Q | BRCA | 1 |
p.Q117* | BRCA | 1 |
p.N516Y | LUSC | 1 |
p.Q66H | SKCM | 1 |
p.E440Q | COAD | 1 |
p.R122Q | SKCM | 1 |
p.D470N | SKCM | 1 |
p.W36X | SKCM | 1 |
p.Q171X | THCA | 1 |
p.K399Q | UCEC | 1 |
p.P133T | LUSC | 1 |
p.S361C | HNSC | 1 |
p.R46Q | UCEC | 1 |
p.E37K | SKCM | 1 |
p.R517K | HNSC | 1 |
p.E44G | LIHC | 1 |
p.Y188* | UCS | 1 |
p.L564Q | SKCM | 1 |
p.E532Q | BRCA | 1 |
p.K343E | KIRP | 1 |
p.P536H | STAD | 1 |
p.A233P | HNSC | 1 |
p.P522S | SKCM | 1 |
p.R46* | PAAD | 1 |
p.R50Q | SARC | 1 |
p.D542N | SKCM | 1 |
p.M265V | LUAD | 1 |
p.A169V | COAD | 1 |
p.I27T | HNSC | 1 |
p.S232L | SKCM | 1 |
p.P133H | LUSC | 1 |
p.E369K | SKCM | 1 |
p.I404M | LUAD | 1 |
p.W36* | SKCM | 1 |
p.Q141H | LUSC | 1 |
p.M40I | LUAD | 1 |
p.M400I | ESCA | 1 |
p.Q259X | LIHC | 1 |
p.S498R | COAD | 1 |
p.E67Q | UCEC | 1 |
p.Q66* | SKCM | 1 |
p.K195N | SKCM | 1 |
p.L251I | LUAD | 1 |
p.R72Q | LAML | 1 |
p.E532* | UCEC | 1 |
p.P126S | SKCM | 1 |
p.M22I | THYM | 1 |
p.C303* | LUAD | 1 |
p.E325Q | BLCA | 1 |
p.E145K | SKCM | 1 |
p.T8M | HNSC | 1 |
p.T104R | BLCA | 1 |
p.E401Q | LUAD | 1 |
p.S166Y | UCEC | 1 |
p.R290X | COAD | 1 |
p.L21S | SKCM | 1 |
p.Y188X | UCS | 1 |
p.E342K | SKCM | 1 |
p.D541N | SKCM | 1 |
p.A391D | LUAD | 1 |
p.E228K | SKCM | 1 |
p.D48N | UCEC | 1 |
p.E17D | THCA | 1 |
p.G434E | SKCM | 1 |
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TissGeneCNV for CCDC67 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC67 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUSC | TCGA-34-5236-01A | PANX1-CCDC67 | Out-of-frame | Chr11:93862659 | Chr11:93170709 |
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TissGeneNet for CCDC67 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC67 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC67 |
TissGeneDrug for CCDC67 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC67 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004096 | Asthma | 1 | GAD |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |