TissGeneSummary for EXD1 |
Gene summary |
Basic gene information | Gene symbol | EXD1 |
Gene name | exonuclease 3'-5' domain containing 1 | |
Synonyms | EXDL1 | |
Cytomap | UCSC genome browser: 15q15.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001286441.1, NM_152596.3, | |
Description | exonuclease 3'-5' domain-containing protein 1exonuclease 3'-5' domain-like-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000178997 | ||
HPRD : 14571 | ||
Vega : OTTHUMG00000130232 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_EXD1 | |
BioGPS: 161829 | ||
Pathway | NCI Pathway Interaction Database: EXD1 | |
KEGG: EXD1 | ||
REACTOME: EXD1 | ||
Pathway Commons: EXD1 | ||
Context | iHOP: EXD1 | |
ligand binding site mutation search in PubMed: EXD1 | ||
UCL Cancer Institute: EXD1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of EXD1 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for EXD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -1.039439309 | 0.746538277 | -1.785977586 | 3.44E-11 | 2.21E-10 |
LUSC | -1.172424265 | 0.316769853 | -1.489194118 | 5.03E-08 | 1.46E-07 |
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TissGene-miRNA for EXD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for EXD1 |
TissGeneSNV for EXD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G285R | BLCA | 2 |
p.S190F | SKCM | 2 |
p.R152I | UCEC | 2 |
p.E400K | CESC | 1 |
p.R314L | COAD | 1 |
p.R320K | SKCM | 1 |
p.R112C | PAAD | 1 |
p.N124H | UCEC | 1 |
p.E223X | COAD | 1 |
p.D288N | SKCM | 1 |
p.R260S | THYM | 1 |
p.G401E | SKCM | 1 |
p.P50H | ESCA | 1 |
p.P392L | SKCM | 1 |
p.S220F | SKCM | 1 |
p.D406N | HNSC | 1 |
p.E420K | HNSC | 1 |
p.M146I | SKCM | 1 |
p.W118X | KICH | 1 |
p.M37V | UCEC | 1 |
p.A23E | UCEC | 1 |
p.A439T | ESCA | 1 |
p.P366S | UCEC | 1 |
p.L355I | STAD | 1 |
p.D150Y | LUAD | 1 |
p.E474K | SKCM | 1 |
p.P496S | SKCM | 1 |
p.K151N | READ | 1 |
p.R152K | SKCM | 1 |
p.S286T | STAD | 1 |
p.R112H | UCEC | 1 |
p.E349D | LUAD | 1 |
p.R314C | STAD | 1 |
p.E234* | UCEC | 1 |
p.Q98K | ACC | 1 |
p.N391T | ESCA | 1 |
p.Q388L | SKCM | 1 |
p.S242L | SKCM | 1 |
p.S20L | SKCM | 1 |
p.A91V | STAD | 1 |
p.A122G | DLBC | 1 |
p.L219V | SARC | 1 |
p.W236* | SKCM | 1 |
p.P543A | LUSC | 1 |
p.L175M | LUAD | 1 |
p.S190P | SKCM | 1 |
p.R239* | LAML | 1 |
p.A253T | BLCA | 1 |
p.D363Y | UCEC | 1 |
p.E303K | SKCM | 1 |
p.R314C | HNSC | 1 |
p.D44G | UCEC | 1 |
p.E420V | HNSC | 1 |
p.E207D | GBM | 1 |
p.R283S | BLCA | 1 |
p.G346W | COAD | 1 |
p.F360V | BLCA | 1 |
p.G285A | SKCM | 1 |
p.I153M | UCEC | 1 |
p.R283H | LUAD | 1 |
p.S384Y | UCEC | 1 |
p.V334E | SKCM | 1 |
p.T293I | STAD | 1 |
p.T251M | GBM | 1 |
p.S61F | SKCM | 1 |
p.Q170* | SKCM | 1 |
p.E284K | COAD | 1 |
p.P366L | LGG | 1 |
p.Q170X | SKCM | 1 |
p.I153M | LGG | 1 |
p.S4N | COAD | 1 |
p.A51T | THYM | 1 |
p.E420M | HNSC | 1 |
p.Q388K | SKCM | 1 |
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TissGeneCNV for EXD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for EXD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | DA687098 | EXD1-RFWD2 | chr15:41478381 | chr1:176054914 |
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TissGeneNet for EXD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for EXD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for EXD1 |
TissGeneDrug for EXD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for EXD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |